Method for preparing hydroxylapatite/polylactic acid composite biological coating on surface of magnesium alloy

A technology of hydroxyapatite and bio-coating, which is applied in the direction of coating, etc., can solve the problems that cannot meet the practical application requirements, the hydroxyapatite coating is not very dense, and the mechanical properties are poor, so as to improve the biodegradability , The composition of the solution and the operation process are simple, and the effect of good binding force

Active Publication Date: 2009-04-22
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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AI Technical Summary

Problems solved by technology

At the same time, it solves the problems that HA has poor mechanical properties and cannot be used independently as a stressed part,...

Method used

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preparation example Construction

[0030] The preparation method of the magnesium alloy surface hydroxyapatite / polylactic acid composite bioactive coating of the present invention, the steps are as follows:

[0031] (1) Pre-treatment: Pre-treatment includes two steps of degreasing and pickling, each step must be washed with water.

[0032] The degreasing liquid is 10-70g / l of alkali metal hydroxide, 15-50g / l of carbonate, 20-70g / l of phosphate, 10-80g / L of bicarbonate, one or more of them prepared aqueous solution. Soak the magnesium alloy sample in a degreasing solution at a temperature of 60-90°C for 2-20 minutes to remove residual grease and dirt on the surface of the magnesium alloy.

[0033]Described hydroxide can be sodium hydroxide, potassium hydroxide, carbonate can be sodium carbonate, potassium carbonate, phosphate can be sodium phosphate, potassium phosphate, bicarbonate can be sodium bicarbonate, potassium bicarbonate.

[0034] The pickling aqueous solution adopts 10-80 g / l of dihydrogen phosphate...

Embodiment 1

[0051] The sample is a die-cast AZ91D magnesium alloy with a size of 30mm×25mm×5mm. The specific operation steps are as follows:

[0052] 1. Degreasing: the degreasing solution is composed of sodium hydroxide 50g / L, sodium phosphate 40g / l, sodium carbonate 30g / l aqueous solution, the temperature is 70°C, and the time is 8min, to remove the residual grease and dirt on the surface of the magnesium alloy;

[0053] 2. Pickling: The pickling aqueous solution uses ammonium dihydrogen phosphate 30g / l and potassium fluoride 0.5g / l. The degreased magnesium alloy sample was immersed in the pickling solution at room temperature for 60s to remove the oxide and rust layer on the surface of the sample.

[0054] 3. Electrodeposited calcium phosphate coating: The electrodeposition aqueous solution is composed of calcium nitrate 0.1M, sodium dihydrogen phosphate 0.06M, and hydrogen peroxide 20ml / l. Sodium hydroxide adjusted the pH to 4.3. The pickled magnesium alloy sample was used as the ca...

Embodiment 2

[0061] The sample is an extruded AZ31 D magnesium alloy with a size of 30mm × 25mm × 2mm, which differs from Example 1 in that:

[0062] 1. Pickling: The pickling solution uses sodium dihydrogen phosphate 50g / l and sodium fluoride 1g / l. The degreased magnesium alloy sample was immersed in the pickling solution at room temperature for 30s to remove the oxide and rust layer on the surface of the sample.

[0063] 2. Electrodeposited calcium phosphate coating: The electrodeposition aqueous solution is composed of calcium chloride 0.05M, ammonium hydrogen phosphate 0.03M, ethanol 200ml / l, and hydrochloric acid to adjust the pH to 4.1. The magnesium alloy sample was used as the cathode, and the titanium plate was used as the anode. The power supply voltage was adjusted to 1.5V. After 3 hours of electrodeposition, it was taken out and dried to obtain a mixture coating composed of various calcium phosphates with a thickness of 20 μm.

[0064] 3. Polylactic acid solution: Weigh 2.5g o...

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Abstract

The invention belongs to the field of a biomaterial, in particular to a preparation method for hydroxyapatite/polylactic acid composite biological coat on magnesium alloy surface, and solves the problem that an electrolytic deposition hydroxyapatite (HA) coat is not quite compact through sealing treatment of polylactic acid, so that the composite coat can improve corrosion resistance of magnesiumalloy in human body fluid remarkably, and biological degradability of the composite coat is used for adjusting service cycle of the magnesium alloy in vivo. The preparation method is as follows: the magnesium alloy is subjected to electrolytic deposition in water solution consisting of calcium salt, dihydrogen phosphate or hydrogen phosphate or other additives, so as to obtain a mixture coat of several calcium phosphates; the mixture coat is treated by alkali metal hydroxide solution and then transformed into an even HA coat; the HA coat is soaked in polylactic acid solution and subjected to the sealing treatment; and finally the HA coat is dried to obtain the hydroxyapatite/polylactic acid composite coat. The preparation method which combines biological activity of the HA and biological degradability of the polylactic acid organically is used for corrosion protection of the magnesium alloy in biotic environment.

Description

technical field [0001] The invention relates to the application of magnesium alloys in biomaterials, and belongs to the field of biomaterials, in particular to a method for preparing a composite bioactive coating of hydroxyapatite / polylactic acid on the surface of magnesium alloys. Background technique [0002] Since the 1960s, biomaterials have developed rapidly as a substitute for repairing bone damage. Biomaterials currently in clinical use mainly include metal materials, ceramic materials, and polymer materials. But each material has its disadvantages, such as metal materials will dissolve metal ions harmful to the human body, ceramic materials are brittle, and polymer materials are not strong enough. In comparison, magnesium and its alloys have many potential advantages as medical biomaterials: (1) magnesium resources are abundant and cheap; (2) the density of magnesium is 1.74g / cm 3 , the density is the smallest among all structural materials, which is comparable to ...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/32
Inventor 宋影伟单大勇韩恩厚
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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