Vitamin D3 microcapsule and preparation method thereof

A technology for vitamins and microcapsules, applied in the field of microcapsules and their preparation, can solve the problems of oil encapsulation only reaching about 10%, poor dispersibility, poor emulsifying stability, low entrapment rate, etc. The effect of photolysis and high embedding rate

Inactive Publication Date: 2009-09-23
ZHEJIANG GARDEN BIOCHEM HIGH TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] but vitamin D 3 It is easily photolyzed, oxidized, unstable to heat, and insoluble in water, which greatly limits its use
Prior art mainly utilizes gelatin, white sugar and starch to wrap vitamin D 3 , produced by fluidized bed drying process, which does not belong to microcapsule technology, its product has poor dispersion and emulsification stability in water, and the embedding rate is not high, and the oil content can only reach about 10%

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Weigh feed grade vitamin D 3 12.5 kg of oil (4 million IU / g) (note: 1.25 kg of vitamin D and 11.25 kg of vegetable oil), accounting for 12.5% ​​of the total weight, placed in an oil-dissolving kettle, adding 0.5 kg of antioxidant BHT as a percentage of the total weight 0.5%, raise its temperature to about 60°C, and then add oil-soluble emulsifiers such as glycerol monostearate and soybean lecithin, each of 0.5 kg. The above materials are used as the oil phase, and they are dissolved evenly and placed in the water phase kettle Add 5 kg of casein, 4 kg of carrageenan, 76.5 kg of maltodextrin, 150 kg of deionized water, raise the temperature of the water phase to 80-90°C, dissolve the wall material evenly, and then add the oil phase in the oil-dissolving kettle to the water phase In the kettle, mix and stir for 30 minutes, then beat it into a homogenizer for homogenization, the homogenization pressure is 30MPa for the first stage, and 15MPa for the second stage, emulsify i...

Embodiment 2

[0030] Weigh vitamin D 3 Crystallization (40 million IU / g) 0.1 kg, dissolved in 3 kg of vegetable oil, placed in an oil-dissolving kettle, and 0.1 kg of antioxidant DL-α-tocopherol was added, the temperature was raised to 50 ° C, and then oil-soluble Emulsifier soybean lecithin 0.5 kg, the above materials as the oil phase, dissolve it evenly, add 15 kg of gum arabic, 80 kg of maltodextrin, and 120 kg of deionized water in the water phase kettle, and the temperature of the water phase rises to 50 ° C ~ 60°C, dissolve the wall material evenly, then add the oil phase in the oil-dissolving tank to the water phase tank, mix and stir for 30 minutes, and then put it into a homogenizer for homogenization. The pressure is 10MPa, it is emulsified into microcapsules with a diameter of 1-100μm, and then spray-dried, the air inlet temperature is controlled at 170°C-180°C, the outlet temperature is controlled at 85°C-95°C, and vitamin D is formed by spraying 3 Microcapsules, and add 1.3 ki...

Embodiment 3

[0032] Weigh resinous oil vitamin D 3 (about 25 million IU / g) 2 kg, dissolved in 1.5 kg of vegetable oil, placed in an oil-dissolving kettle, and added with 0.3 kg of antioxidant BHA, and then added with an oil-soluble emulsifier of 0.3 kg of glyceryl monostearate, Sodium stearoyl lactylate 0.45 kg, raise its temperature to 65-70°C, use the above materials as the oil phase, dissolve it evenly, add 1.15 kg of sodium caseinate, 1 kg of gelatin, and 8 kg of maltodextrin into the water phase kettle , 10 kg of deionized water, the temperature of the water phase rises to 60-80°C, dissolves the wall material evenly, then adds the oil phase in the oil-dissolving kettle to the water phase kettle, mixes and stirs for 30 minutes, and then beats into a homogenizer for homogenization The homogeneous pressure is 30MPa for the first stage and 20MPa for the second stage. It is emulsified into microcapsules with a diameter of 1-100μm, and then sprayed under pressure. The air inlet temperature ...

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Abstract

The invention relates to a microcapsule and a preparation method thereof, aiming at providing a vitamin D3 microcapsule and a preparation method thereof. The vitamin D3 microcapsule comprises core material vitamin D3, oil fat, an oil-soluble emulsifier and a wall material. The preparation method comprises the following steps of: (1) adopting the core material vitamin D3, the oil fat, the oil-soluble emulsifier as oil phase for dissolving and mixing evenly; (2) adding deionized water in the wall material, stirring and dissolving as water phase; (3) adding the oil phase into the water phase, mixing, stirring evenly, then carrying out homogenization and emulsifying the obtained mixture into microcapsule; (4) carrying out spray drying to the microcapsule to form the vitamin D3 microcapsule; and (5) screening, mixing, inspecting and packing to obtain the finished product. The microcapsule and the preparation method thereof have the advantages of high embedding rate, good flowability, hard photolysis, oxidation, high heat stability, even dispersion in water and the like. The microcapsule can be widely added into food or feedstuff, is easy to be absorbed by the human body or animals, also can be used as original drug of rat poison to strengthen the stability thereof greatly.

Description

technical field [0001] The present invention relates to a kind of microcapsule and preparation method thereof, especially vitamin D 3 Microcapsules and methods for their preparation. Background technique [0002] Vitamin D 3 It is an indispensable fat-soluble vitamin for the growth, development, reproduction, maintenance of life and health of humans and animals. Its main function is to regulate calcium and phosphorus metabolism, promote intestinal calcium and phosphorus absorption and bone calcification, and maintain blood calcium and blood phosphorus balance. Vitamin D 3 It can be used as a feed additive, and it is an essential fat-soluble vitamin for the growth, breeding, maintenance of life and health of livestock and poultry; it can be used as a pharmaceutical preparation, and it can be used clinically to treat rickets, rickets, osteoporosis, and thyroid function It can also be used as a food nutrition fortifier, added to milk, dairy products, cereal biscuits and gra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/593A61K47/44A61P3/02A61P19/08A61P19/10A61P5/14A61P35/00A61P9/00A61P25/18A23L1/303A23K1/16A01N31/06A01N25/28A01N25/00A01P11/00A23K20/174A23K40/30A23L33/155A61K47/18A61K47/42
Inventor 张彩菊单振哲刘建刚马焕政
Owner ZHEJIANG GARDEN BIOCHEM HIGH TECH
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