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Alginic acid inorganic nanometer composite gel microspheres and preparation method

An inorganic nano-composite gel technology, applied in the preparation of microspheres, microcapsule preparations, pharmaceutical formulations, etc., can solve the problems of low mechanical strength and high water absorption, and achieve the effect of promoting sustained release and safe preparation process

Inactive Publication Date: 2009-12-30
SHANGHAI NAT ENG RES CENT FORNANOTECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] After searching the prior art, it was found that Baipai, S.K.; Saxena, S., in a document entitled "The Release Dynamics of Model Drugs from the Psyllium and N-hydroxymethylacrylamide Based Hydrogels" (React Funct Polym 2004, 59, 115) A method for preparing alginic acid gel microspheres is described, but the alginic acid microsphere matrix prepared by this technology has a large hole structure inside, which leads to various defects such as large drug release, low mechanical strength and high water absorption.

Method used

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  • Alginic acid inorganic nanometer composite gel microspheres and preparation method
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  • Alginic acid inorganic nanometer composite gel microspheres and preparation method

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Embodiment 1

[0032] 1) Sodium alginate is added to distilled water, mechanically stirred at room temperature of 20° C. and configured into a sodium alginate solution with a mass concentration of 2%, and then single-walled carbon nanotubes and quantitative EPE are added to distilled water. Stir evenly at room temperature at 20°C, set the power of ultrasonic dispersion to 100W, and the frequency of ultrasonic waves to 40 kHz. After ultrasonic dispersion for 20 minutes, the dispersion is obtained. Finally, the dispersion is centrifuged at 8000rpm for 10 minutes to remove solid precipitation and obtain the mass concentration. 2% carbon nanotube suspension solution;

[0033] 2) According to the volume ratio of the sodium alginate solution and the carbon nanotube suspension solution as 1:1, mix the sodium alginate solution and the carbon nanotube suspension solution, and stir to obtain a carbon nanotube sodium alginate mixed solution. At this time, the sodium alginate The mass percentage account...

Embodiment 2

[0038] The volume ratio of the sodium alginate solution and the carbon nanotube suspension solution is 3:1 to replace the volume ratio of the sodium alginate solution and the carbon nanotube suspension solution in Example 1 to be 1:1 with the volume ratio of the sodium alginate solution and the carbon nanotube suspension solution. The mass percentage of the total mass of sodium, carbon nanotubes and EPE is 75%; at the same time, multi-walled carbon nanotubes are used; other steps are the same as in Example 1.

[0039] The alginic acid inorganic nanocomposite gel microspheres prepared in this example have the following components and their mass percentages: 1.5% alginic acid, 0.5% carbon nanotubes, triblock surfactant polyethylene oxide-polymer Propylene oxide-polyethylene oxide 0.5%, the balance is water.

[0040] By increasing the mass fraction of sodium alginate in the solution, the structure of the prepared alginate gel microspheres is tighter, and the mechanical strength i...

Embodiment 3

[0042]1) Add potassium alginate to distilled water, and mechanically stir at room temperature to form a potassium alginate solution with a mass concentration of 6%; Stir evenly at high temperature, and ultrasonically disperse to obtain a dispersion; the dispersion is centrifuged at 8000 rpm for 10 minutes to remove solid precipitates, and a carbon nanotube suspension solution with a mass concentration of 10% is obtained;

[0043] 2) According to the volume ratio of potassium alginate solution and carbon nanotube suspension solution is 91:9, potassium alginate solution and carbon nanotube suspension solution are mixed, and now potassium alginate accounts for potassium alginate, carbon nanotube and EPE total The mass percentage of mass is 98%;

[0044] 3) Use a syringe with a 9# needle to drop the carbon nanotube potassium alginate mixture into a calcium chloride solution with a mass concentration of 10% to obtain an ion-crosslinked gel particle composited with alginate carbon n...

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Abstract

The invention relates alginic acid inorganic nanometer composite gel microspheres and a preparation method; the gel microspheres comprise the following components by weight percent: 1-7% of alginate, 0.5-10% of carbon nanotubes, 1-50% of triblock surfactant polyethylene oxide-polypropylene oxide-polyethylene oxide and the balance water. The production process of the gel microspheres is safe, simple and effective and accords with the requirements of environmental protection. The alginic acid carbon nanotubes composite gel microspheres which is prepared by the preparation method of the invention and is introduced with carbon nanotubes can relieve the swelling speed of the complexed alginic acid microspheres, can be used as a carrier to combine with drugs, proteins, enzymes and other biological products and can be used as a drug carrier owning to the pH sensitivity of the composite gel microspheres.

Description

technical field [0001] The invention relates to a nanometer material in the technical field of bioengineering and a preparation method thereof, in particular to an alginic acid inorganic nanocomposite gel microsphere and a preparation method thereof. Background technique [0002] In recent years, research on carbon nanotubes in the field of biomedicine has attracted more and more attention. Carbon nanotubes are regarded as ideal reinforcing fillers for polymer matrices, which can achieve high performance and special functions. This is mainly due to the Nanoscale, high flexibility, high specific surface area, low density, and more importantly, its outstanding mechanical, electrical, and thermal properties are rapidly forming a new research direction. The recent related research aimed at biomedical applications mainly involves the surface modification of carbon nanotubes, so that they can prevent non-specific adsorption of proteins and recognize specific protein molecules. in...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/36A61K47/04A61K47/34B01J13/14
Inventor 黄进惠忠英范红蕾余家会何丹农盛小海沈新程
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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