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Super paramagnetism inorganic nanometer microballoon and preparation method thereof

An inorganic nano and superparamagnetic technology, applied in advanced nano materials and nano fields, can solve the problems of high biological toxicity and difficult application, and achieve the effects of strong external magnetic field responsiveness, low cytotoxicity, and easy availability of raw materials

Inactive Publication Date: 2010-02-03
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, cetyl ammonium bromide, polystyrene and polyacrylic acid are all highly biotoxic, so these materials are still difficult to be applied in biotechnology

Method used

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  • Super paramagnetism inorganic nanometer microballoon and preparation method thereof
  • Super paramagnetism inorganic nanometer microballoon and preparation method thereof
  • Super paramagnetism inorganic nanometer microballoon and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Precursor FeCl 3 (0.65g, 4mmol) and stabilizer trisodium citrate (0.20g, 0.68mmol) were ultrasonically dissolved in 20ml of ethylene glycol, then sodium acetate (1.20g, 14.6mmol) was added, stirred evenly and transferred to 50ml polytetrafluoroethylene Vinyl liner, stainless steel outer jacket, react at 200°C for 8 hours, then cool to room temperature, separate superparamagnetic inorganic nano-microspheres from the solution by magnet, and wash repeatedly with ethanol and distilled water successively. figure 1 Scanning electron micrographs of superparamagnetic nanospheres.

Embodiment 2

[0024] Precursor FeCl 3 (0.32g, 2mmol), MnCl 2 (0.25g, 2mmol) and trisodium citrate (0.20g, 0.68mmol) were ultrasonically dissolved in 20ml ethylene glycol, then sodium acetate (1.20g, 14.6mmol) was added, stirred evenly and transferred to 50ml polytetrafluoroethylene The gallbladder was reacted at 200° C. for 8 hours in a hydrothermal kettle with a stainless steel jacket, and then cooled to room temperature. The superparamagnetic inorganic nanometer microspheres were separated from the solution by a magnet, and washed repeatedly with ethanol and distilled water in sequence. figure 2 Scanning electron micrographs of superparamagnetic nanospheres.

Embodiment 3

[0026] Precursor FeCl 3 (0.32g, 2mmol), MnCl 2 (0.25, 2mmol) and trisodium citrate (0.20g, 0.34mmol) were ultrasonically dissolved in 10mL ethylene glycol and 10mL diethylene glycol, then sodium acetate (1.20g, 14.6mmol) was added, stirred evenly and transferred to 50ml polytetrafluoroethylene liner, react in a stainless steel jacketed hydrothermal kettle at 210°C for 8 hours, then cool to room temperature, separate the superparamagnetic inorganic nano-microspheres from the solution by a magnet, and repeat with ethanol and distilled water successively. washing. image 3 Scanning electron micrographs of superparamagnetic nanospheres.

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Abstract

The invention belongs to advanced nanometer material and nanotechnology field, in particular to a super paramagnetism inorganic nanometer microballoon and a preparation method thereof. The super paramagnetism inorganic nanometer microballoon has grain diameters of 80-410nm and hydrophilic surfaces, wherein the magnetism inorganic nanometer microballoon is formed by nano particles with grain diameters of 6-10nm; the nano particles are one or more than one of Fe3O4, Gamma-Fe2O3, MnFe2O4, NiFe2O4 and CuFe2O4; and the surface of the magnetism nanometer microballoon is coated by organic hydrophilicmicromolecule which is one or more than one of oxalic acid, citric acid, dihydroxysuccinic acid, and malic acid. The microballoon has bigger grain diameter and strong external field responsibility, and simultaneously keeps the super paramagnetism character; as the microballon has hydrophilic surface, the microballon can well disperse in water solution. Cell experiments show that the microballon has very low cytotoxicity and is particularly suitable for use in biomedicine, such as cell marks, separation and magnetic resonance imaging, etc.

Description

technical field [0001] The invention belongs to the field of advanced nanometer materials and nanotechnology, and specifically relates to a superparamagnetic inorganic nanometer microsphere and a preparation method thereof. Background technique [0002] In recent years, due to their unique properties, magnetic nanospheres have been widely used in the fields of catalysis, environmental engineering, biomedicine, clinical diagnosis, and information storage and processing. And when the size of the magnetic nanoparticle is reduced to a critical value, it can have superparamagnetism, and it will not show its own magnetization under the action of no external magnetic field. This property makes it widely used in drug loading, cell separation, magnetic resonance imaging and other fields. (Huh, Y.-M.; Jun, Y.; Song, H.-T.; Kim, S.J.; Choi, J.-S.; Lee, J.-H.; Yoon, S.; Kim, K. .-S.; Shin, J.-S.; Suh, J.-S.; Cheon, J.J.Am.Chem.Soc.2005, 127, 12387.Son, S.J.; Reichel, J.; Schuchman, M...

Claims

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Application Information

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IPC IPC(8): H01F1/11B22F1/02B22F9/00
Inventor 刘嘉邓勇辉赵东元
Owner FUDAN UNIV
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