Preparation method of hydroxy methionine salt and compound

A technology of hydroxymethionine salt and complex, applied in the field of compound food or feed additive, can solve the problems of not conforming to the experimental facts, increased production cost, waste of raw materials, etc. Effect

Inactive Publication Date: 2010-06-16
李宁 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the problem that it exists is: have stronger corrosiveness and irritating smell, storage, transportation, inconvenient to use, must use expensive special-purpose liquid feeding system (Zhou Jiankang Chinese patent: a kind of compound that is used to supplement methionine and calcium and its production and preparation method, CN1493560A, on May 5th, 2004); the storage time is slightly longer (4 months), and the oligomers with less nutritional value in the liquid will multiply (up to more than 50mol%)
Although the direct mixing method has low equipment investment, simple process route and low production cost, it has obvious shortcomings: (1) It is difficult to carry out the reaction thoroughly
Because MHA itself is relatively viscous, and Ca(OH) 2 Or when CaO dry powder is reacted according to the stoichiometric ratio, even if the dead angle of the coulter type stirred reactor is not considered, it is easy to form the phenomenon that the raw material is wrapped and partially wrapped by the product, resulting in a decrease in the purity of the product; if the excessive MHA is formed during the reaction Fluid, it will increase the production cost, and the subsequent drying process will become more difficult (MHA has a high boiling point, about 170°C at 300Pa, higher at normal pressure)
(2) The product is difficult to dry, causing serious environmental pollution
The aqueous solution method can solve the problem that the target product is difficult to dry, and has a fast reaction rate and is environment

Method used

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  • Preparation method of hydroxy methionine salt and compound
  • Preparation method of hydroxy methionine salt and compound
  • Preparation method of hydroxy methionine salt and compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1: magnesium hydroxymethionine (Mg(C 5 h 9 o 3 S) 2 ) preparation

[0046] In an airtight, corrosion-resistant reaction vessel, add dehydrated alcohol (dehydrated alcohol: magnesium hydroxide=25, molar ratio), hydroxymethionine (MHA) and magnesium hydroxide (Mg(OH) in a molar ratio of 2:1 ) 2 ), 80 ° C stirring reaction 2.0h. The product was filtered by suction, washed with alcohol (the filtrate was recovered for use), and dried to obtain the product. Its chemical reaction equation is as follows:

[0047]

[0048] The analytical data of the prepared magnesium hydroxymethionine are shown in Table 1, and the product morphology is shown in Figure 1.

Embodiment 2

[0049] Embodiment 2: magnesium hydroxymethionine (Mg(C 5 h 9 o 3 S) 2 ) preparation

[0050] In sealable, corrosion-resistant reaction vessel, add the reclaimed ethanol (reclaimed ethanol: magnesium hydroxide=25, mol ratio) among the embodiment 1, the hydroxymethionine (MHA) of 2: 1 and magnesium hydroxide ( Mg(OH) 2 ), 80 ° C stirring reaction 2.0h. The product was filtered by suction, washed with alcohol (the filtrate was recovered for use), and dried to obtain the product.

[0051] The analytical data of the prepared magnesium hydroxymethionine are shown in Table 1, and the product morphology is shown in Figure 1.

[0052] The analytical data of the magnesium hydroxymethionine prepared by the present invention of table 1

[0053]

[0054] a. Measured according to the method described in the national standard GB / T 21034-2007, take the average value of three measurements of the sample; b. See attached drawing 1, the diameter of the submicron wire is 0.5-1.5um, and t...

Embodiment 3

[0055] Embodiment 3: Hydroxymethionine calcium (Ca(C 5 h 9 o 3 S) 2 ) preparation

[0056] In an airtight, corrosion-resistant reaction vessel, add dehydrated alcohol (dehydrated alcohol: calcium hydroxide=15, molar ratio), hydroxymethionine (MHA) and calcium hydroxide (Ca(OH) in a molar ratio of 2:1 ) 2 ), kept stirring at 85°C for 0.5h. The product was filtered by suction, washed with alcohol (the filtrate was recovered for use), and dried to obtain the product. Its chemical reaction equation is as follows:

[0057]

[0058] The analytical data of the prepared calcium hydroxymethionine are shown in Table 2, and the morphology of the product is shown in Figure 2.

[0059] The analytical data of the calcium hydroxymethionine prepared by the present invention of table 2

[0060]

[0061] a. Measured according to the method described in the national standard GB / T 21034-2007, the average value of the three measurements of the sample is taken; b. Referring to Figure ...

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Abstract

The invention provides a preparation method of hydroxy methionine salt and a compound, comprising the following steps: a. feeding metal hydroxide or basic metal oxide or amphoteric metal oxide and 2-hydroxy-4-methylthiobutyricacid into a closed and corrosion resistant reaction kettle to react for 0.5-12h according to a stoichiometric ratio, taking the low-boiling polar organic solvent or the mixed solvent thereof with water as the reaction medium, stirring, separating the target product, washing and drying to obtain the products; and b. recycling the reaction medium. The preparation method of the invention has short route, no consumption of acid or alkali reagent, low cost, easily-controllable product quality, environmental friendliness and the like, thus being applicable to large-scale industrial production.

Description

technical field [0001] 1. The present invention relates to the composite food or feed additive that can simultaneously supplement methionine, calcium and multiple trace elements (magnesium, manganese, iron, cobalt, nickel, copper, zinc) necessary for animal growth and development. [0002] 2. The present invention relates to the current technical route and process flow of hydroxymethioninate and organic trace elements, improving, innovating and developing the green chemical preparation and production process of high-quality hydroxymethioninate and complexes. Background technique [0003] Hydroxymethionine is also known as methionine hydroxyl analogue (MHA for short), and its trade name is The chemical name is 2-hydroxyl-4-methylthiobutyric acid (2-hydroxyl-4-(methylthio)butyric acid), which is a highly acidic organic acid (pH 1-2). It is formed by the reaction of 3-methylthiopropionaldehyde (3-(methylthio) propionaldehyde) and hydrocyanic acid (HCN) to generate the corresp...

Claims

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Application Information

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IPC IPC(8): C07C323/52C07C319/20
Inventor 李宁盖利刚
Owner 李宁
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