Porous polymer nanoparticle and preparation method thereof

A technology of nano-microspheres and polymers, which is applied in the direction of microsphere preparation, microcapsule preparations, chemical instruments and methods, etc., to achieve wide application prospects, simple equipment, and low environmental dependence

Inactive Publication Date: 2010-06-16
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Porous polymer nanoparticle and preparation method thereof
  • Porous polymer nanoparticle and preparation method thereof
  • Porous polymer nanoparticle and preparation method thereof

Examples

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Embodiment 1

[0041] Embodiment 1: Preparation of polyphenylene sulfone sulfone porous nano-microspheres:

[0042] Add 10 g of polyphenylene sulfide sulfone and 300 g of N-methylpyrrolidone into a dissolution kettle equipped with a stirrer and a thermometer, stir and dissolve at a temperature of 100°C, defoam at a vacuum degree of 0.3 MPa for 1 hour, and ripen for 12 hours to produce a battery. Spray solution. Electrostatic spraying is sprayed into an aqueous receiving bath of N-methylpyrrolidone, stirred, and the solidification of the microspheres is completed by an immersion precipitation phase inversion method to obtain polyphenylene sulfone sulfone porous nanometer microspheres. The temperature of the receiving bath is 10° C., the ambient humidity is 50%, the spraying voltage is 10 kv, and the spraying distance is 10 cm. The above microspheres were placed in a Soxhlet extraction device, extracted with deionized water, and extracted at a temperature of 90° C. for 4 hours to remove the s...

Embodiment 2

[0043] Embodiment 2: Preparation of polyphenylene sulfide sulfone amide porous nano-microspheres:

[0044]Add 50g of polyphenylene sulfide sulfoneamide, 5g of sodium chloride and 500g of N-methylpyrrolidone into a dissolution kettle equipped with a stirrer and a thermometer, stir and swell at a temperature of 30°C until dissolved, and defoam at a vacuum of 0.1MPa for 2 hours , aged for 12 hours to make an electrospray solution. Electrostatic spraying is sprayed into the aqueous solution receiving bath of dimethyl sulfoxide, stirred, and the solidification of the microspheres is completed through the immersion precipitation phase inversion method, and the polyphenylene sulfide sulfone amide porous nanometer microspheres are obtained. The temperature of the receiving bath is 50° C., the ambient humidity is 76%, the spraying voltage is 15 kv, and the spraying distance is 1 cm. Put the above-mentioned microspheres in a Soxhlet extraction device, extract with deionized water, and ...

Embodiment 3

[0045] Embodiment 3: Preparation of polyphenylene sulfide sulfone amide porous nano-microspheres:

[0046] Add 100g of polyphenylene sulfide sulfone amide, 15g of calcium chloride and 900g of N,N-dimethylacetamide into a dissolution kettle equipped with a stirrer and a thermometer, stir and dissolve at a temperature of 50°C, and desorb at a vacuum degree of 0.1MPa. Soak for 2 hours and mature for 12 hours to make an electrospray solution. Electrostatic spraying is sprayed into the receiving bath of the mixed solution of ethanol and water, stirred, and the solidification of the microspheres is completed by the immersion precipitation phase inversion method, and the polyphenylene sulfide sulfone amide porous nanometer microspheres are obtained. The temperature of the receiving bath is 40°C, the ambient humidity is 95%, the spraying voltage is 25kv, and the spraying distance is 4cm. The above microspheres were placed in a Soxhlet extraction device, extracted with deionized water...

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Abstract

The invention discloses a porous polymer nanoparticle and a preparation method thereof. The method is characterized by adding 10-200 parts of polymers, 0-200 parts of additives and 300-1000 parts of solvents by weight into a dissolution kettle with a stirrer and a thermometer, stirring to dissolve the mixture at 30-100 DEG C and obtaining polymer solution through defoaming and aging; and placing the polymer solution into an electrostatic field under 5-25kV to prepare the porous nanoparticle through electrostatic spraying. Smooth split of the nanoparticle is realized by a frozen breaking method, thus achieving the aims of minute observation, research and control of the inside structure of the nanoparticle. Electron microscope scanning test result shows that the diameter of the nanoparticle is distributed from hundreds of nanometers to thousands of nanometers, and the nanoparticle matrices are all of porous structure. The porous nanoparticles in the shapes of balls, red blood cells and round lanterns can be prepared by changing the technological conditions. The nanoparticle has the advantages of small diameter, large specific surface area and controllable surface and inside structure and is used in such fields as drug release, catalyst carriers, chemical sensors, biomolecule analysis, gas chromatography, ion exchange and polymerization carriers.

Description

Technical field: [0001] The invention relates to a polymer porous nano-microsphere and a preparation method thereof, belonging to the field of preparation of porous nano-microsphere materials. Background technique: [0002] Polymer microspheres refer to polymer materials or polymer composite materials with diameters ranging from nanometers to micrometers and spherical or other geometric shapes. Its shape can be varied, including solid, hollow, porous, dumbbell-shaped, onion-shaped, etc. Due to its special size and shape, polymer microspheres have special functions that other materials do not have, and have been widely used in nanotechnology, biochemistry, electronic information, drug release and other fields. [0003] There are many methods for preparing polymer microspheres, which can be roughly divided into two types: one is the preparation method of microspheres based on monomers, such as emulsion polymerization, soap-free emulsion polymerization, dispersion polymerizati...

Claims

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Application Information

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IPC IPC(8): C08L81/06C08L81/10C08L79/04C08L5/08C08L67/04C08K3/24C08L29/04C08L71/08C08L33/26B01J13/12A61K47/34A61K9/16B01J32/00B01J31/06C08F4/02
Inventor 杨杰张全超王孝军龙盛如刘静
Owner SICHUAN UNIV
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