Traditional Chinese medicine preparation of new Zhongsheng pill and preparation method thereof

A technology for traditional Chinese medicine preparations and Zhongsheng Pills, which is applied in the directions of pill delivery, pharmaceutical formulations, and non-active ingredients medical preparations, etc. The problems of different sizes, etc., can shorten the production cycle, lengthen the dissolution time limit, and reduce the drying process.

Active Publication Date: 2010-12-08
GUANGDONG ZHONGSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The quality standard production process of Zhongsheng Pill is to decoct part of the medicinal materials in the prescription with water in a traditional multifunctional extraction tank. The extract is concentrated into an extract with a three-effect concentrator. The paste powder is mixed with Dannanxing powder and artificial bezoar, and the traditional molding method is used to make pills. This production process has obvious defects
After the extract of the medicinal materials of Zhongsheng Pills is concentrated into an extract, the extract is spray-dried with a spray dryer, and the air temperature of the spray dryer reaches 200-300°C. The extract will be destroyed due to the high drying temperature. , whi...

Method used

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  • Traditional Chinese medicine preparation of new Zhongsheng pill and preparation method thereof
  • Traditional Chinese medicine preparation of new Zhongsheng pill and preparation method thereof
  • Traditional Chinese medicine preparation of new Zhongsheng pill and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0126] Example 1 (Preparation of Xinzhongsheng Pills):

[0127] 160g of dry ointment powder of Zhongsheng pills, 30g of bilinanstar powder, 20g of artificial bezoar, 50g of hydroxypropyl cellulose, 37.5g of microcrystalline cellulose, 38.5g of lactose, 4g of silicon dioxide, and 5g of magnesium stearate to make 1000 pills.

[0128] Take 1 / 2 bilinanstar powder and lactose through a 0.8mm sieve (50Hz) with a granulator, and then feed them into the mixer together with the remaining bilinanstar powder, artificial bezoar, hydroxypropyl cellulose and microcrystalline cellulose , Pre-mixed for 20 minutes and then release the material. [U6] Take the dry ointment powder of Zhongsheng Pills, the premix of bilinanstar powder and lactose, artificial bezoar, hydroxypropyl cellulose, microcrystalline cellulose, silicon dioxide, magnesium stearate After passing through a 2.5mm sieve (45Hz) with a granulator, the materials are fed into the mixer together and mixed for 30 minutes. Pills are made b...

Embodiment 2

[0129] Example 2 (Preparation of Xinzhongsheng Pills):

[0130] Zhongsheng Pills dry powder 200g, bilinanstar 30g, artificial bezoar 20g, hydroxypropyl cellulose 40g, microcrystalline cellulose 25g, lactose 25g, silicon dioxide 5g, magnesium stearate 5g, made into 1000 pills.

[0131] Take 1 / 2 bilinanstar powder and lactose through a 0.8mm sieve (50Hz) with a granulator, and then feed them into the mixer together with the remaining bilinanstar powder, artificial bezoar, hydroxypropyl cellulose and microcrystalline cellulose , Pre-mixed for 20 minutes, then release the material, take the dry ointment powder of Zhongsheng pill, the premix of bilinanstar powder and lactose, artificial bezoar, hydroxypropyl cellulose, microcrystalline cellulose, silicon dioxide and magnesium stearate The granulator passes through a 2.5mm sieve (45Hz) and is fed into the mixer together for a total of 30 minutes of mixing. Pills are made by high-speed pill pressing, the size of the spherical die is 7.9m...

Embodiment 3

[0132] Example 3 (Preparation of Xinzhongsheng Pill):

[0133] Zhongsheng Pill dry cream powder 160g, bilinanstar powder 30g, artificial bezoar 20g, hydroxypropyl cellulose 14.5g, microcrystalline cellulose 18.5g, lactose 18.5g, magnesium stearate 1.25g, silicon dioxide 2.5g, made into 1000 pills .

[0134] Take 1 / 2 bilinanstar powder and lactose through a 0.8mm sieve (50Hz) with a granulator, and then feed them into the mixer together with the remaining bilinanstar powder, artificial bezoar, hydroxypropyl cellulose and microcrystalline cellulose , Pre-mixed for 20 minutes, then release the material, take the dry ointment powder of Zhongsheng pill, the premix of bilinanstar powder and lactose, artificial bezoar, hydroxypropyl cellulose, microcrystalline cellulose, silicon dioxide and magnesium stearate The granulator passes through a 2.5mm sieve (45Hz) and then is fed into the mixer together for a total of 30 minutes of mixing. The pellets are made by high-speed pill pressing, th...

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Abstract

The invention relates to a preparation method of a new Zhongsheng pill, which comprises the following steps of: extracting and concentrating the traditional Zhongsheng pill preparation twice to prepare an extract; controlling the material temperature to 40-80 DEG C and preparing the extract into dry extract powder by adopting a vacuum belt drier; and after uniformly mixing the dry extract powder, arisaema cum bile powder, calculus bovis factitius and auxiliary materials, pelleting by adopting a pressing process. The production process for preparing the pill by the traditional plastic injection method is replaced by a pressing process for preparing pills. The whole preparation process of the new Zhongsheng pill is mild and ensures that the retaining rate of main active components in the traditional Chinese medicine preparation is improved by 30-294 percent, the energy consumption in the production process is reduced by 50-80 percent, and the production cycle is shortened by more than 60 percent. The method of the invention overcomes the defect of different pill sizes in the traditional plastic injection method, remarkably improves the active components and the pharmaceutical curative effect of the new Zhongsheng pill preparation and remarkably shortens dissolution time limit; and the preparation method of the new Zhongsheng pill improves the labour productivity, reduces the energy consumption and the pollutant emission in the production process and meets the Chinese policy of energy saving, emission reduction and benefit improvement.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine preparation of Xinzhongsheng Pills and a method for preparing the Xinzhongsheng Pills, in particular to a method for preparing the Xinzhongsheng Pills by vacuum belt drying of the Chinese medicine extract into a dry extract and pelletizing by a compression method. Background technique [0002] Zhongsheng Pills is one of the exclusive varieties of Guangdong Zhongsheng Pharmaceutical Co., Ltd., the implementation of the Ministry of Health issued the standard Zhongsheng Pills (WS 3 -B-2880-98), the prescription consists of Radix Isatidis, Bupleurum, Red Peony Root, Angelica, Polygonum cuspidatum, Scutellaria, Dandelion, Scrophulariaceae, Viola, Parsnip, Angelica, Gangmei, Dannanxing, Prunella, Trichosanthes, Artificial Bezoar Seventeen medicinal materials such as saponaria thorn, etc., its functions are mainly to clear away heat and detoxify, promote blood circulation and cool blood, reduce inflammation an...

Claims

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Application Information

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IPC IPC(8): A61K36/86A61K9/28A61K47/38A61P11/00A61P11/04A61P17/00A61K35/413
Inventor 龙超峰谢称石陈木洲赵希平
Owner GUANGDONG ZHONGSHENG PHARMA
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