Oral liquid slow-release preparation containing ondansetron and preparation method thereof

A technology for ondansetron and sustained-release preparations, which is applied in the field of ondansetron-containing oral sustained-release liquid preparations and its preparation, can solve the problems of difficulty in dividing doses, constant taking, and difficulty swallowing, so as to improve the quality of life, Good taste and prolonged action time

Inactive Publication Date: 2011-05-18
DONGGUAN MATHEMATICAL ENG ACAD OF CHINESE MEDICINE GUANGZHOU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the problems of difficulty in swallowing and difficulty in dividing doses of the sustained-release tablet, elderly and children patients cannot take it, which affects the completion of the normal treatment plan and the exertion of the drug effect.

Method used

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  • Oral liquid slow-release preparation containing ondansetron and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0079] The ingredient mass composition of the oral liquid sustained-release preparation is as follows:

[0080] Ondansetron

1.6g

Styrene strongly acidic cation exchange resin

8g

polyethylene glycol

4g

Ethyl cellulose

6.5g

Diethyl phthalate

0.5g

Disodium edetate

2g

hypromellose

16.5g

xanthan gum

5.g

Ethylparaben

1g

sucrose

200g

strawberry flavor

1g

peppermint

0.5g

Deionized water

Add to 1000g

[0081] Preparation Process:

[0082] Take an appropriate amount of deionized water, add ondansetron under stirring until completely dissolved, then add 8 g of styrene strong acidic cation exchange resin, stir for 6 hours, let stand, filter, and wash with an appropriate amount of deionized water to obtain a filter cake; filter cake at 50 After drying under reduced pressure at ℃, add 4g of polyethylene glycol solution to make soft material, dry the sof...

specific Embodiment 2

[0084] The ingredient mass composition of the oral liquid sustained-release preparation is as follows:

[0085] Ondansetron

0.8g

Styrene strongly acidic cation exchange resin

5g

Polyvinylpyrrolidone

1.2g

polyacrylic resin

4.5g

citric acid

3g

Dibutyl phthalate

0.3 grams

hypromellose

16.5g

xanthan gum

5g

Ethylparaben

1g

lactose

5g

peppermint

1g

aspartame

0.5g

Deionized water

Add to 1000g

[0086] Preparation Process:

[0087] Wet-pack 5g of styrene strong acidic cation exchange resin into a glass exchange column, take deionized water, add 0.8g of ondansetron under stirring until completely dissolved, then introduce the ondansetron solution into the ion exchange resin glass column , slowly open the bottom control valve, make the ondansetron aqueous solution slowly flow through the ion exchange resin at a flow rate of 0.5ml / min, receive the e...

specific Embodiment 3

[0089] The ingredient mass composition of the oral liquid sustained-release preparation is as follows:

[0090] Ondansetron

1.6g

Styrene strongly acidic cation exchange resin

8g

glycerin

30g

Cellulose acetate

4.5g

Diethyl phthalate

0.4g

Disodium Calcium EDTA

2.6g

microcrystalline cellulose

16.5g

Sodium carboxymethyl cellulose

2.5g

Tragacanth Gum

4.5g

Methylparaben

0.5g

Propylparaben

1.5g

sucrose

200g

orange flavor

1g

citric acid

1.5g

Tween 80

0.6g

Deionized water

Add to 1000g

[0091] Preparation Process:

[0092] Take an appropriate amount of deionized water, add ondansetron under stirring until completely dissolved, then add 8 g of styrene strong acidic cation exchange resin, stir for 6 hours, let stand, filter, and wash with an appropriate amount of deionized water to obtain a filter cake; filter cake at 50 ...

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PUM

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Abstract

The invention discloses an oral liquid slow-release preparation containing ondansetron and a preparation method thereof. The preparation comprises ondansetron, ion exchange resin, a hydrophilic or water soluble material, a coating material, a plasticizer, a suspending agent, a metal ion complexing agent, a surfactant, a preservative, a flavoring agent and deionized water. The ondansetron is absorbed on the ion exchange resin to form particles externally coated with the coating material and the medicated resin coating particles are distributed uniformly in a liquid medium of the suspending agent and the deionized water in a suspension manner. The preparation method comprises the steps of preparing the medicated resin, coating the medicated resin and preparing the medicated resin suspension. Compared with prior art, the invention has the advantages of obvious slow-release effect, reduced frequency of taking, good taste and great convenience for medication of patient in chemotherapy.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to an oral slow-release liquid preparation containing ondansetron and a preparation method thereof. Background technique [0002] The oral liquid sustained-release drug delivery system is a multiphase compound system, and it is a controlled-release dosage form administered in the form of liquid suspension or emulsion. It not only has some advantages of controlled-release tablets or capsules, but also has the following advantages: 1), it is especially suitable for patients with swallowing difficulties (such as the elderly and children), and can improve the patient's medication compliance; 2), it can be used according to individual needs 3) After oral administration, the distribution area in the gastrointestinal tract is large, and the absorption is thorough; 4), the stimulation to the gastrointestinal tract is reduced, and the process in the body is r...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K9/16A61K31/4178A61K47/30A61K47/32A61P1/08
Inventor 王羚郦王健松
Owner DONGGUAN MATHEMATICAL ENG ACAD OF CHINESE MEDICINE GUANGZHOU UNIV OF CHINESE MEDICINE
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