Photopolymeric composite material containing polyethylene glycol grafted hydroxyapatite and preparation method thereof
A technology of branched hydroxyapatite and polyethylene glycol, which is applied in prosthesis, medical science, etc., can solve the problems of reducing the mechanical properties and biological activity of composite materials, uneven dispersion of hydroxyapatite, and formation of defects, etc., to achieve Avoid highly traumatic, reduce medical costs, fast curing effect
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Embodiment 1
[0025] Dissolve 20g of PEG200 and 10.1g of triethylamine in 250ml of dichloromethane, place at 0°C for 1 hour, dissolve 9.05g of acryloyl chloride in 100ml of dichloromethane and put it in a dropping funnel, under the protection of nitrogen Add slowly and stir vigorously. After dropping, react overnight at room temperature. After the reaction, the amine salt was removed by suction filtration, the filtrate was washed with 1 mol / L hydrochloric acid, 1 mol / L sodium bicarbonate and deionized water respectively, and the liquid was separated. The organic phase was collected and anhydrous sodium sulfate was added overnight. After suction filtration, the filtrate was rotary evaporated to remove the solvent to obtain PEG(200)MA.
[0026] Take 6.41g of p-phenylene diisocyanate and 5 drops of dibutyltin dilaurate dissolved in 250ml of chloroform, take the prepared PEG (200) MA 10.88g and dissolve it in 80ml of chloroform and put it in the dropping funnel, at 35°C , slowly added dropwis...
Embodiment 2
[0029] Dissolve 40g of PEG400 and 10.1g of triethylamine in 250ml of toluene, place at 0°C for 1 hour, dissolve 10.5g of methacryloyl chloride in 100ml of toluene and place in a dropping funnel, under the protection of nitrogen, Add slowly and stir vigorously. After dropping, react overnight at room temperature. After the reaction, the amine salt was removed by suction filtration, the filtrate was washed with 1 mol / L hydrochloric acid, 1 mol / L sodium bicarbonate and deionized water respectively, and the liquid was separated. The organic phase was collected and anhydrous sodium sulfate was added overnight. After suction filtration, the filtrate was rotary evaporated to remove the solvent to obtain PEG(400)MA.
[0030] Take 139.93g of toluene diisocyanate and 5 drops of DBTDL dissolved in 250ml of acetone, take the prepared PEG (400) MA 18.88g dissolved in 80ml of acetone and put it in the dropping funnel, at 35 ° C, slowly drop it under the protection of nitrogen and vigorousl...
Embodiment 3
[0033] Dissolve 30g PEG600 and 5.05g triethylamine in 250ml of dichloromethane, place at 0°C for 1h, dissolve 48.5g propylene isocyanate in 100ml of dichloromethane and place in a dropping funnel, under the protection of nitrogen Add slowly and stir vigorously. After dropping, react overnight at room temperature. After the reaction, the amine salt was removed by suction filtration, the filtrate was washed with 1 mol / L hydrochloric acid, 1 mol / L sodium bicarbonate and deionized water respectively, and the liquid was separated. The organic phase was collected and anhydrous sodium sulfate was added overnight. After suction filtration, the filtrate was rotary evaporated to remove the solvent to obtain PEG(600)MA.
[0034]Take 8.89g of isophorone diisocyanate and 5 drops of DBTDL dissolved in 250ml of ethyl acetate, take the prepared PEG (600) MA 26.88g and dissolve it in 150ml of ethyl acetate and put it in the dropping funnel, at 35°C, nitrogen Slowly added dropwise and vigorou...
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Abstract
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