New preparation formulation-paper patch used for preventing diseases of local oral cavity

Abstract

The invention relates to a new preparation formulation using high-quality pure paper (or containing medicament) to be made into paper patch and particular applied to local oral cavity. The paper patch is formed by making a soft paperboard by 36-48 layers of paper with 0.15-0.2cm and cutting into the shape of rectangular strip with 3cm length and 1.2cm width. The paper patch has stronger absorbency, adsorbability, adsorption polymerization (adsorbing and polymerizing antibiosis substances of saliva and gingival crevicular fluid), and hemostatic and protective properties, can getter bacterium, endotoxin and inflammatory cytokines, as well as suppuration smell and bacterial plaque. The new preparation formulation has the functions of eliminating inflammation to stop pain, and stopping bleeding and diminishing swelling, further can protect the mucosa barrier of the oral cavity so as to be free from of invasion of bacterium and endotoxin on the blood and cause cardio-cerebrovascular diseases. Shown by initial trial, the new preparation formulation has tremendous curative effect on toothache. The medicament-containing paper patch can have the effect of being fast in action and high in curative effect, reducing adverse reaction and improving safety. When being used in hypogloeeis, the paper patch provides a novel hypogloeeis paper patch for hypogloeeis administration for treating intracorporal disease, especially cardiovascular disease and respiratory system disease. The product has no adverse effect, is absolutely safe, simple to administrate, no smell and stimulation, and good mouthfeeling, and can be popular with any people. The product is easy to produce, rich in raw materials and low in cost.

Description

technical field [0001] The invention relates to a paper patch made of high-quality pure paper (or containing medicine), which becomes a new dosage form specially used for preventing and treating diseases in the oral cavity. Background technique [0002] Periodontal disease is one of the most common diseases. Because every tooth has the potential to develop disease. Up to 80% of Chinese residents suffer from periodontal disease, and over 97% of middle-aged and elderly people suffer from it. [0003] The main manifestations of periodontal disease are red and swollen gums, bleeding, pus, gingival recession, loose teeth, and eventually tooth loss. [0004] Toothache is a painful torment that many people have suffered. They can't eat or sleep. It's uncomfortable! [0005] However, the impact of periodontal disease on human health is not limited to the oral cavity, far more than the teeth themselves. [0006] Dental experts clearly and positively pointed out: periodontal infec...

AI Technical Summary

Problems solved by technology

As for the pulpitis and periapical periodontitis that can hurt the teeth the most, the toothache caused is unbearable, and medicine does not work, so we have to go to the hospital to extract the tooth, or do root canal treatment, which is time-consuming, labor-intensive and labor-intensive. It costs money, but its success rate is not 100%, currently only 70-90%

[0015] At present, the treatment of periodontal disease at home and abroad mainly uses mechanical methods to scrape off dental plaque and calculus, and cooperates with topical medication of diseased teeth. Tetracycline drugs are often used to make sustained-release and controlled-release preparations, such as tetracycline fiber drug thread, doxycycline Gel injection, minocycline ointment injection and minocycline microsphere injection, inject the medicine into the periodontal pocket or fill it into the diseased part, so as to eliminate the pathogenic bacteria of periodontal inflammation. Although this method has achieved It has a good curative effect, but its shortcomings are also very obvious. First, the treatment is complicated and must be operated by a doctor in a medical unit, which is difficult for patients to accept. Therefore, it is difficult to promote this method. Second, there are many bacteria in the oral cavity, reaching more than 300 The pathogenic bacteria that cause periodontal inflammation are not a single kind, but mostly caused by two or more pathogenic bacteria, and the pathogenic bacteria are commonly used in clinical periodontal disease antibiotics, such as tetracycline antibiotics, metronidazole, large Resistance to cyclic lactone antibiotics, beta lactam antibiotics (including penicillins and cephalosporins), and fluoroquinolones

cause greater difficulty to this law, and may even lead to failure in the end

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