Near-infrared silver sulfide quantum dots, preparation method and application thereof

A silver sulfide and quantum dot technology, applied in the fields of material chemistry and biology, can solve the problems of insufficient near-infrared fluorescence intensity, poor uniformity and dispersion, complicated preparation methods, etc., and achieves short preparation period, easy control, Good size uniformity

Active Publication Date: 2011-12-14
苏州影睿光学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Low-toxic or even non-toxic silver sulfide (Ag sulfide) with near-infrared fluorescence 2 S) Quantum dots have been reported (Near-infrared photoluminescent Ag 2 S quantum dots from a single source precursor.J.Am.Chem.Soc., 2010, 132, 1470), but the particles are too large, and the near-infrared fluorescence intensity is not strong enough
For Ag reported in other literatu

Method used

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  • Near-infrared silver sulfide quantum dots, preparation method and application thereof
  • Near-infrared silver sulfide quantum dots, preparation method and application thereof
  • Near-infrared silver sulfide quantum dots, preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0040] 0.1mmol of silver diethyldithiocarbamate and 10g of dodecanethiol were mixed in a flask, and placed in a N 2 The temperature was raised to 200°C in the atmosphere and kept for 1 hour. Finally, after the solution was naturally cooled to room temperature, 50 mL of absolute ethanol was added, centrifuged, washed, and dispersed in cyclohexane. The obtained sample was identified as single oblique Ag 2 S quantum dots (the particle size is about 5nm, such as figure 1 shown), obtained a very good as figure 2 Shown near-infrared fluorescence emission spectrum; 0.15g lipoic acid is added in the above-mentioned cyclohexane, then add the same volume of dehydrated alcohol, ultrasonic 4h in the ultrasonic cleaner, centrifuge then, wash with deionized water, obtain particle diameter at Water-soluble Ag around 5nm 2 S quantum dots, the fluorescence emission is still very strong (such as image 3 shown); 0.25mg of the above Ag 2S quantum dots were dispersed in 100 μL dimethyl sulf...

Embodiment 2

[0042] Mix 0.1mmol of silver nitrate, 8g of dodecanethiol and 5.4g of oleylamine in a three-necked flask, raise the temperature to 180°C in the air and keep it for 1h. Finally, after the solution is naturally cooled to room temperature, add 50mL of absolute ethanol and centrifuge , washed, dispersed in cyclohexane, and the resulting sample was identified as monoclinic Ag by X-ray diffraction using a transmission electron microscope. 2 S quantum dots, the particle size of which is below 8nm, and also has a good near-infrared fluorescence emission spectrum; 0.2g L-cysteine ​​is added to the above-mentioned cyclohexane, and then an equal volume of absolute ethanol is added, stirred for 24h, and then Centrifuge and wash with deionized water to obtain water-soluble Ag with a particle size of about 8nm 2 S quantum dots, its fluorescence emission is still very strong; 0.25mg of the above Ag 2 S quantum dots were dispersed in 100 μL dimethyl sulfoxide (DMSO), and then 50 μL DMSO solu...

Embodiment 3

[0044] Mix 0.1 mmol of silver thiobenzoate, 8 g of cetyl mercaptan and 2 g of trioctylphosphine oxide in a three-necked flask, raise the temperature to 160°C in the air and keep it for 4 hours. Finally, after the solution is naturally cooled to room temperature, add 50 mL of Water ethanol, after centrifugation and washing, disperse in cyclohexane; add 0.1g mercaptopropionic acid to the above cyclohexane, then add the same volume of absolute ethanol, shake on the oscillator for 8h, then centrifuge, use deionized Washing with water to obtain water-soluble Ag with a particle size of about 6nm 2 S quantum dots, the fluorescence emission is still very strong; 0.25mg of the above Ag 2 S quantum dots were dispersed in 100 μL dimethyl sulfoxide (DMSO), and then 50 μL DMSO solution containing 0.01 mmol NHS was mixed with the above solution; then 50 μL DMSO solution containing 0.01 mmol EDC was added to the above mixed solution, and covered with aluminum foil Wrap, stir for 1h, centrif...

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Abstract

The invention discloses a near-infrared silver sulphide quantum dot as well as a preparation method and application thereof. The silver sulphide quantum dot has a monoclinic phase structure, the particle diameter of the silver sulphide quantum dot is below 8nm, and the surface of the silver sulphide quantum dot can be connected and modified with a hydrophilic group of hydrophilic reagent containing sulfydryl. The preparation method comprises the following steps: fully reacting a mixed reaction system containing silver source and long-chain mercaptan in a sealed environment; cooling the mixed reaction system, and then adding a polar solvent; carrying out centrifugation and wshing to obtain a hydrophobic near-infrared silver sulphide quantum dot; fully mixing the hydrophobic near-infrared silver sulphide quantum dot and hydrophilic reagent containing sulfydryl in organic solvent to react; and carrying out centrifugation and washing the reacting mixture to obtain the biocompatibility near-infrared silver sulphide quantum dot. The quantum dot disclosed by the invention has the advantages of high fluorescence yield, good fluorescence stability, good biocompatibility and even size, and can be used for biological tissue imaging; and the preparation technology has moderate condition, short period and good repeatability, is simple to operate and is easy to control.

Description

technical field [0001] The invention particularly relates to a near-infrared silver sulfide quantum dot with high fluorescence yield, its preparation method and its biological application, belonging to the technical fields of material chemistry and biology. Background technique [0002] As a basic method of biomedical research, fluorescent labeling and detection technology will play an important role in the research of the three levels of subcellular level, cellular level and living body level. Quantum dot fluorescence imaging technology has many unique advantages in S, such as for The tissue penetration depth is large, which can overcome the defect that visible light quantum dots are susceptible to interference when performing deep tissue imaging. Therefore, it has attracted widespread attention in medical diagnostics, molecular biology, and cell biology. Currently common near-infrared quantum dots contain toxic elements such as Cd, Se, and Te. Low-toxic or even non-toxic...

Claims

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Application Information

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IPC IPC(8): C09K11/58G01N21/64
CPCG01N21/64C09K11/58G01N33/588A61K49/0067C01G5/00C09K11/025C09K11/582A61K49/0013C07F1/005
Inventor 王强斌张叶俊
Owner 苏州影睿光学科技有限公司
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