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Aqueous vitamin liposome for injection and preparation method thereof

A technology for water-soluble vitamins and liposomes, applied in the field of medicine, can solve problems such as poor stability, difficulty in reaching the validity period, inconvenience, etc., achieve safety assurance, solve the problem of quality stability, and reduce toxic and side effects.

Inactive Publication Date: 2012-04-04
傅苗青
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims at the disadvantages in the prior art that the water-soluble vitamins are easy to oxidize and have poor stability, which brings great inconvenience to the storage and transportation of the product and is difficult to reach the expiration date, and provides a kind of vitamin with good stability, which is not easy to freeze-dry during the freeze-drying process. A water-soluble vitamin liposome for injection that can be broken due to dehydration, fusion, ice crystal formation, etc., can maintain a good encapsulation rate after hydration and rethawing, and is convenient for product transportation and storage and its preparation method

Method used

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  • Aqueous vitamin liposome for injection and preparation method thereof
  • Aqueous vitamin liposome for injection and preparation method thereof
  • Aqueous vitamin liposome for injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Water-soluble vitamin liposomes for injection, which are powder injections, are freeze-dried preparations obtained by encapsulating water-soluble vitamins with liposomes formed by liposome skeleton materials containing antioxidants and stabilizers, including the following parts by weight Ingredients of raw materials (calculated based on 1000 bottles of prescription):

[0032] Thiamine nitrate 3.1g

[0033] Riboflavin sodium phosphate 4.9g

[0034] Niacinamide 40g

[0035] Pyridoxine hydrochloride 4.9g

[0036] Sodium pantothenate 16.5g

[0037] Vitamin C sodium 113g

[0038] Biotin 60mg

[0039] Folic acid 0.4g

[0040] Vitamin B 12 5.0mg

[0041] Glycine 300g

[0042] Methyl p-hydroxybenzoate 0.5g

[0043] Disodium ethylenediaminetetraacetate 0.5g

[0044] Soy Lecithin 1500g

[0045] Cholesterol 400g

[0046] Glucose 5g

[0047] Mannitol 5g

[0048] Vitamin E 2g.

[0049] The preparation method of the water-soluble vitamin liposome for injection in the above technical sch...

Embodiment 2

[0055] Water-soluble vitamin liposomes for injection, which are powder injections, are freeze-dried preparations obtained by encapsulating water-soluble vitamins with liposomes formed by liposome skeleton materials containing antioxidants and stabilizers, including the following parts by weight Ingredients of raw materials (calculated based on 1000 bottles of prescription):

[0056] Thiamine nitrate 3.2g

[0057] Riboflavin sodium phosphate 4.7g

[0058] Niacinamide 39g

[0059] Pyridoxine hydrochloride 5.2g

[0060] Sodium pantothenate 17.2g

[0061] Vitamin C sodium 116g

[0062] Biotin 62mg

[0063] Folic acid 0.42g

[0064] Vitamin B 12 5.3mg

[0065] Glycine 300g

[0066] Methyl p-hydroxybenzoate 0.5g

[0067] Disodium ethylenediaminetetraacetate 0.5g

[0068] Hydrogenated egg yolk phospholipids 1000g

[0069] Polyethylene glycol-distearyl phosphatidylcholine 600g

[0070] Stigmasterol 400g

[0071] Trehalose 7.5g

[0072] Vitamin E 2.5g.

[0073] The preparation method of...

Embodiment 3

[0079] Water-soluble vitamin liposomes for injection, which are powder injections, are freeze-dried preparations obtained by encapsulating water-soluble vitamins with liposomes formed by liposome skeleton materials containing antioxidants and stabilizers, including the following parts by weight Ingredients of raw materials (calculated based on 1000 bottles of prescription):

[0080] Thiamine nitrate 2.9g

[0081] Riboflavin sodium phosphate 5.0g

[0082] Niacinamide 42g

[0083] Pyridoxine hydrochloride 4.6g

[0084] Sodium pantothenate 15.5g

[0085] Vitamin C Sodium 105g

[0086] Biotin 56mg

[0087] Folic acid 0.38g

[0088] Vitamin B 12 5.8mg

[0089] Glycine 300g

[0090] Methyl p-hydroxybenzoate 0.5g

[0091] Disodium ethylenediaminetetraacetate 0.5g

[0092] Hydrogenated soybean lecithin 500g

[0093] Polyethylene glycol-phosphatidylcholine 1000g

[0094] Cholesterol 300g

[0095] Sucrose 20g

[0096] Glutathione 1.8g.

[0097] The preparation method of the water-sol...

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Abstract

The invention which relates to the technical field of medicines discloses an aqueous vitamin liposome for injection and a preparation method thereof. The aqueous vitamin liposome for injection, which is a powder injection, is a lyophilized preparation obtained by entrapping with a liposome which is formed by an antioxidant-contained liposome framework material and a stabilizer. The liposome comprises the following raw materials, by weight, 1 part of an aqueous vitamin, 2-10 parts of the liposome framework material, 0.5-5 parts of the stabilizer, 2-20 parts of a lyophilization protecting agent, and 0.1-2 parts of the oxidant. The aqueous vitamin liposome prepared in the invention allows the chemical stability and the physical activity of the aqueous vitamin for injection to be improved and condition requirements of production, transportation and storage to be reduced.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a water-soluble vitamin liposome for injection and a preparation method thereof. Background technique [0002] Water-soluble vitamins include vitamin C and B vitamins, which are trace organic compounds necessary to maintain the body's normal physiological functions and material metabolism, ensure the efficient operation of the body, and prevent the body's stress syndrome. [0003] As a component of dozens of coenzymes in the body, water-soluble vitamins are essential for enzymes that catalyze the metabolism of carbohydrates, lipids and proteins; they are also important for drug metabolism, capture of free radicals, prevention of cell damage and peroxidation of organelle membranes required. At the same time, water-soluble vitamins are a group of compounds that are difficult to synthesize and store in the body, and must be obtained from food in a quantitative and regular manner. ...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K31/714A61K47/28A61K47/32A61K47/34A61K47/36A61P3/02A61K31/197A61K31/375A61K31/4188A61K31/4415A61K31/455A61K31/51A61K31/519A61K31/525
Inventor 傅苗青周白水
Owner 傅苗青