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Preparation method of porous tantalum as medical metal implant material

An implant material, porous tantalum technology, which is applied in the field of porous medical metal implant materials, can solve the problems of insufficient purity of finished products, reduced biological safety, carbon skeleton residues, etc., and achieve the goal of reducing impurity content, increasing porosity, and uniform quality Effect

Active Publication Date: 2012-05-23
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limitations of its preparation method, the purity of the obtained finished product is not enough, and there are carbon skeleton residues, resulting in a decrease in biological safety

Method used

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  • Preparation method of porous tantalum as medical metal implant material
  • Preparation method of porous tantalum as medical metal implant material
  • Preparation method of porous tantalum as medical metal implant material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Weigh 8 g of ethyl cellulose and put it into a container containing 240 ml of absolute ethanol; place it on an electric stove to heat and stir to make it an ethyl cellulose ethanol solution. Use a 200g balance to weigh 60g of tantalum powder with an average particle size of less than 10 microns and an oxygen content of less than 0.1%, add 8ml of cooled ethyl cellulose ethanol solution, stir and mix evenly, and make it into a tantalum powder slurry. Use 10×10×30mm porous polyurethane foam (average pore diameter is 0.48mm, density 0.025g / cm 3 , hardness 50°) into it and pour until the pores of the polyurethane foam are filled with tantalum powder slurry, then use clips to take out the polyurethane foam filled with tantalum powder slurry and put it into a porcelain plate. Dry in a vacuum drying oven at a drying temperature of 70° C., a drying time of 5 hours, and a vacuum degree of 1 Pa. Degreasing treatment: vacuum degree 1×10 -3 Pa~1×10 -4 Pa, temperature 6...

Embodiment 2

[0034] Example 2: Weigh 5 g of ethyl cellulose and put it into a container containing 200 ml of absolute ethanol; place it on an electric stove to heat and stir to make it an ethyl cellulose ethanol solution. Use a 200g balance to weigh 40g of tantalum powder with an average particle size of less than 10μm and an oxygen content of less than 0.1%, add 6ml of ethyl cellulose ethanol solution, stir and mix evenly, and make it into a tantalum powder slurry. Use 10×10×25mm porous polyurethane foam (average pore diameter is 0.56mm, density 0.030g / cm 3 , hardness 60 0 ) into it and pour until the pores of the polyurethane foam are filled with the tantalum powder slurry, and the polyurethane foam absorbed with the tantalum powder slurry is taken out with a clip and put into the porcelain plate. Dry in a vacuum drying oven at a drying temperature of 80°C for a drying time of 4 hours and maintain a vacuum of 1×10 -2 Pa. Degreasing treatment: vacuum degree 1×10 -3 Pa, temperature 800...

Embodiment 3

[0037] Example 3: Weigh 6 g of ethyl cellulose and put it into a container containing 220 ml of absolute ethanol; place it on an electric stove to heat and stir to make it an ethyl cellulose ethanol solution. Use a 200g balance to weigh 45g of tantalum powder with an average particle size of less than 10μm and an oxygen content of less than 0.1%, add 8ml of ethyl cellulose ethanol solution, stir and mix evenly, and make it into a tantalum powder slurry. Use 8×8×25mm porous polyurethane foam (average pore size is 0.70mm, density 0.035g / cm 3 , hardness 70°) into it and pour until the pores of the polyurethane foam are filled with tantalum powder slurry, then use a clip to take out the polyurethane foam filled with tantalum powder slurry and put it into a porcelain plate. Dry in a vacuum drying oven, the drying temperature is 90 ° C, the drying time is 4.5 hours, and the vacuum degree is kept at 1×10 -1 Pa. Degreasing treatment: the vacuum degree is lower than 1×10 -3 Pa, temp...

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Abstract

The invention discloses a preparation method of porous tantalum as a medical metal implant material. The preparation method comprises the steps of: preparing tantalum powder slurry by using tantalum powder and a solution prepared from ethyl cellulose and absolute ethyl alcohol, casting the slurry into organic foams, immersing the organic foams until pores of the organic foams are fully filled with the tantalum powder slurry, then, drying to remove dispersants in the organic foams cast with the tantalum powder slurry, performing degreasing treatment in an inert gas protective atmosphere to remove organic binders and the organic foams, sintering under vacuum to obtain a porous sintered body, annealing under vacuum, and performing conventional treatment to obtain the porous tantalum, wherein the tantalum powder has the average particle size being smaller than 10mum and the oxygen content being smaller than 0.1%. The porous tantalum as the medical metal implant material prepared in the invention has a very good biocompatibility and better mechanical performance, and is particularly suitable for being used as the medical implant material for a connecting component at scapulae, skull and facial bones with tissue trauma and damages. Meanwhile, the preparation method is simple in process and easy to control; and an entire preparation process is harmless and has no pollution and no toxic dust, and the porous tantalum has no side effects to human bodies.

Description

technical field [0001] The invention relates to a porous medical metal implant material, in particular to a method for preparing porous tantalum as a medical implant material, in particular to a porous tantalum implant suitable for light-bearing parts of the human body and having good biocompatibility. The method of preparation of the input material. Background technique [0002] Porous medical metal implant materials have important and special purposes such as treating bone tissue trauma and femoral tissue necrosis. The common materials of this type include porous metal stainless steel and porous metal titanium. As a porous implant material used in the treatment of bone tissue trauma and femoral tissue necrosis, its porosity should reach 30-80%, and the pores should be all connected and uniformly distributed, or partially connected and uniformly distributed according to the needs, so that it can be connected with The growth of bone tissue in the human body is consistent, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C1/08C22C27/02A61L27/04A61L27/56
Inventor 阮建明叶雷谢健全节云峰王志强冯华周健
Owner CHONGQING RUNZE PHARM CO LTD
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