Magnetic resonance imaging contrast agent for diagnosis and treatment and preparation method thereof

A magnetic resonance imaging and contrast agent technology, applied in the fields of polymer materials and medical engineering, can solve problems such as low relaxation rate, inability to effectively and clearly diagnose small lesions, and inability to organically combine cancer diagnosis and treatment, and achieve solubility Good, good water solubility and dispersibility, long storage time

Inactive Publication Date: 2012-08-15
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It solves the problems of low relaxation rate of magnetic resonance imaging contrast agents in the prior art, the inability to organically combine cancer diagnosis and treatment, the inability to effectively and clearly diagnose small lesions, and the tracking and observation of drug treatment effects, etc.

Method used

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  • Magnetic resonance imaging contrast agent for diagnosis and treatment and preparation method thereof
  • Magnetic resonance imaging contrast agent for diagnosis and treatment and preparation method thereof
  • Magnetic resonance imaging contrast agent for diagnosis and treatment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Using polyethylene glycol monomethyl ether (PEO-Br) brominated at one end as the initiator, cuprous bromide (CuBr) as the catalyst, PMDETA as the ligand, and anhydrous methanol as the solvent, the molar ratio to the initiator is 80:1 tert-butyl acrylate ( t BA) as a monomer, the two-block polymer PEO- b -P t BA, partially hydrolyzed P under the action of catalyst (TFA) t BA segment, the amphiphilic block copolymer PEO- b -P(AA- stat - t BA).

[0032] Dissolve the synthesized amphiphilic block copolymer with a special group and the drug to be coated such as doxorubicin in the organic solvent THF, the polymer concentration is 10mg / mL, and put it into the dialysis bag after completely dissolving. Dialyze in deionized water for 3 days, and change the water every 24 hours. The final product in the dialysis bag is a nanovesicle assembled by a polymer and encapsulated with a drug.

[0033] Add the solution containing metal ions ferrous and ferric to the dialyzed micell...

Embodiment 2

[0040] Using azobisisobutyronitrile (AIBN) as the initiator, acetonitrile as the solvent, divinylbenzene (DVB) and methacrylic acid (MAA) as monomers with a molar ratio of 80:20:1 to the initiator, at 70 o Under the condition of C, the reaction is carried out to obtain nano-microspheres PMAA-DVB, and the ferrous iron solution containing metal ions is added to the microsphere solution, stirred overnight, then NaOH solution is added, and heated to 60 o C, add excess H dropwise 2 o 2 , stirred for 6 hours and then dialyzed to neutral pH. The obtained brown solution can be used for magnetic resonance T 1 Microspherical contrast agents for imaging.

Embodiment 3

[0042] Using polyethylene glycol monomethyl ether (PEO-Br) brominated at one end as the initiator, cuprous bromide (CuBr) as the catalyst, PMDETA as the ligand, and anhydrous methanol as the solvent, the molar ratio to the initiator is 160:25:1 tert-butyl acrylate ( t BA) and acrylic acid (AA) as monomers were subjected to ATRP reaction to obtain an amphiphilic block polymer PEO- b -P( t BA- stat -AA).

[0043] The synthesized amphiphilic block copolymer with a special group and the drug paclitaxel to be coated were dissolved in the organic solvent DMSO, and the polymer concentration was 0.8 mg / mL. Dialyze in deionized water for 5 hours, and change the water every 0.5 hours. The final product in the dialysis bag is nanovesicles assembled by polymers and encapsulated with drugs.

[0044] Add the solution containing metal ions ferrous iron, ferric iron and manganese ions into the dialyzed vesicle solution, stir overnight, add alkaline solution ammonia water drop by drop...

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Abstract

The invention belongs to the fields of high molecular material and medical engineering, and in particular relates to a magnetic resonance imaging contrast agent for diagnosis and treatment and a preparation method thereof. Nanospheres encapsulating drugs are prepared by self assembly of a group-specific amphipathic block copolymer with drugs, metal ions are absorbed on the surfaces or membranous layers of the nanospheres through ionic bond or complexing action, and then magnetic particles are generated in situ by a chemical method to obtain the nanospheres useful for magnetic resonance imaging. The magnetic nanospheres composed of a polymer and inorganic particles have a stable structure, excellent water solubility and dispersibility, and good biocompatibility and biodegradability, can encapsulate abundant drugs for controllable release, and also can be used as a supersensitive magnetic resonance imaging contrast agent to be widely applied to diagnosis and treatment of disease.

Description

technical field [0001] The invention belongs to the fields of polymer materials and medical engineering, and in particular relates to a magnetic resonance imaging contrast agent for diagnosis and treatment and a preparation method thereof. Background technique [0002] With the development of social economy and the change of human living habits, the morbidity and mortality of cancer show a clear upward trend. At present, there are 24.6 million cancer patients in the world, and almost 7 million people die of cancer every year. The main types of cancer are: lung cancer (about 1.3 million / year), gastric cancer (about 1 million / year), liver cancer (about 660,000 / year) , colon cancer (about 660,000 / year) and breast cancer (about 500,000 / year). [0003] "Early detection", "early diagnosis" and "early treatment" have become recognized as powerful measures to improve the clinical effect of cancer treatment. Early diagnosis and accurate clinical analysis of cancer are directly rela...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/12A61K47/30A61K45/00A61P35/00
Inventor 杜建忠刘秋明任天斌
Owner TONGJI UNIV
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