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Method for preparing D-glucosamine hydrochloride by taking periplaneta americana as raw material

A technology of glucosamine hydrochloride and Periplaneta americana, applied in the field of preparation of glucosamine hydrochloride, can solve the problems of chitin pesticide residues, heavy metal and antibiotic content exceeding the standard, and extraction difficulties, so as to avoid saponification reaction and improve utilization rate , the effect of high extraction rate

Active Publication Date: 2012-08-15
SICHUAN GOODDOCTOR PANXI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1) Alkaline extraction is generally used in the traditional process to degrease and deproteinize. This saponification reaction easily destroys the fat and amino acids in the extract, making the extract unusable;
[0005] 2) The supply of raw materials is affected by regions and seasons, and the calcium content of shrimp and crab shells is too high, which makes extraction difficult; coupled with overfishing in recent years, the number of shrimp and crabs has decreased sharply, resulting in chitin resources. more scarce;
[0006] 3) Due to the increasingly serious problem of environmental pollution, especially water pollution, it has been detected that there are pesticide residues, heavy metals and antibiotics in chitin that exceed the standard, so the quality of products produced with chitin as raw materials is also greatly threatened

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Weigh 100kg of Periplaneta americana adults cultured in the GAP base, freeze at -18°C for 3 hours, crush and pass through a 100-mesh sieve, put the sieved Periplaneta americana adult powder into the reaction kettle, add 400L of absolute ethanol, and stir For 8 hours, filter with a 200-mesh filter cloth, rinse with pure water, filter until there is almost no water dripping, and obtain the filter residue A; in an acid-resistant container, add 400L of hydrochloric acid with a mass fraction of 6%, start stirring, and then add the filter residue A, at room temperature Stir for 16 hours, filter with a 200-mesh filter cloth, rinse with water until neutral, and finally rinse with pure water, filter until there is basically no water dripping, and obtain the filter residue B; add the filter residue B to an alkali-resistant container, add 500L water and 3L mass fraction 10% hydrogen peroxide solution, adjust the pH value to 10 with 10% sodium hydroxide, heat up to 80°C, stir for 3 ...

Embodiment 2

[0035] Weigh 200 kg of Periplaneta americana adults cultured in the GAP base, freeze at -21°C for 4 hours, crush and pass through a 200-mesh sieve, put the sieved Periplaneta americana adult powder into the reactor, add 3400 L of methanol, and stir for 14 hours, filter with a 200-mesh filter cloth, rinse with pure water, filter until there is basically no water dripping, and obtain the filter residue A; in an acid-resistant container, add 3400L of sulfuric acid with a mass fraction of 8%, start stirring, then add the filter residue A, and stir at room temperature For 24 hours, filter with a 200-mesh filter cloth, rinse with water until neutral, and finally rinse with pure water, filter until there is almost no water dripping, and obtain the filter residue B; add the filter residue B to an alkali-resistant container, add 2400L of water and 9kg of thiosulfuric acid Sodium solution, and use 10% sodium hydroxide to adjust the pH value to 11, raise the temperature to 85°C, stir and ...

Embodiment 3

[0039] Weigh 80kg of Periplaneta americana adults cultured in the GAP base, freeze at -24°C for 6 hours, crush and pass through a 300-mesh sieve, put the sieved Periplaneta americana adult powder into the reaction kettle, and then add 2400 L of ethyl acetate , stirred for 20 hours, filtered with a 200-mesh filter cloth, rinsed with pure water, and filtered until there was basically no water dripping to obtain the filter residue A; in an acid-resistant container, add 2400L of hydrochloric acid with a mass fraction of 10%, start stirring, and then add the filter residue A, Stir at room temperature for 32 hours, filter with 200-mesh filter cloth, rinse with water until neutral, and finally rinse with pure water, filter until there is basically no water dripping, and obtain filter residue B; add filter residue B to an alkali-resistant container, add 1600L mass fraction of 6% sodium hypochlorite solution, adjust the pH value to 11 with 10% sodium hydroxide, heat up to 90°C, stir and...

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PUM

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Abstract

The invention discloses a method for preparing D-glucosamine hydrochloride by taking periplaneta americana as raw material. The method comprises the steps of extracting chitin from the periplaneta Americana, and preparing the D-glucosamine hydrochloride from the prepared chitin. According to the method disclosed by the invention, the chitin is extracted from the periplaneta americana by adopting an extraction method through an organic solvent under unique process conditions, thus the extraction rate is high, the quality of the extracted chitin is excellent, and the medical-grade D-glucosamine hydrochloride with the excellent quality can be further prepared; and by adopting the method, an extract from the periplaneta americana and extraction remains can be effectively utilized, and the utilization rate of the raw material can be greatly improved.

Description

technical field [0001] The invention relates to a method for preparing glucosamine hydrochloride, in particular to a method for preparing glucosamine hydrochloride from chitin extracted from Periplaneta americana as a raw material. Background technique [0002] Glucosamine hydrochloride, English D-Glucosamine Hydrochloride, molecular weight 215.5, white crystal or powder, it has important physiological functions to the human body, participates in liver and kidney detoxification, exerts anti-inflammatory and liver-protecting effects, and is effective in treating rheumatoid arthritis and gastric ulcer It has a good curative effect and is also a drug and antibiotic synergist for the treatment of bone and joint diseases; the most important use of glucosamine is one of the main components of cartilage proteoglycans, which can synthesize collagen and hyaluronic acid needed by the human body, repair the Worn articular cartilage can produce and replenish synovial fluid in large quan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H5/06C07H1/00A61P19/02A23L1/09
Inventor 耿福能张乐陈开晓马秀英利雪
Owner SICHUAN GOODDOCTOR PANXI PHARMA
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