The invention discloses a multicolor fluorescent
sulfur quantum dot as well as a preparation method and application thereof, and relates to the field of fluorescent
quantum dots. The method comprises the following steps: mixing
sodium thiosulfate, hexadecyl trimethyl
ammonium bromide and sulfydryl-containing
amino acid or a derivative thereof in water, and reacting the mixture in a continuous heating and stirring state; and filtering and dialyzing the obtained product to obtain pure fluorescent
sulfur quantum dots. According to the method, the yellow fluorescent
sulfur quantum dots are prepared for the first time, the yellow fluorescent sulfur quantum dots are also SQDs with the longest emission
wavelength at present, and due to the fact that long-
wavelength fluorescence has higher tissue penetrating power, the sulfur quantum dots can be better applied to
tissue imaging. According to the method, sulfur
powder and
sodium hydroxide used as raw materials in a previous method are abandoned for the first time,
sodium thiosulfate and
amino acid are used as substitutes in a breakthrough mode, pure green synthesis of the quantum dots is successfully achieved, the safety and stability of the synthesis process are guaranteed, and a
solid foundation is laid for industrial production of the sulfur quantum dots.