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On-line purified multimode conduction surface plasma resonance spectrometer

A technology of plasmon resonance and conductive surface, which is applied in the direction of instruments, scientific instruments, measuring devices, etc., can solve the problems of large differences in concentration composition, lack of sample pretreatment function, and inability to meet the number of samples, etc., to achieve rapid detection and high-pass Quantitative testing, to achieve the effect of accurate quantitative detection

Inactive Publication Date: 2014-12-03
王利兵
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is: to overcome the lack of sample pretreatment function when using prism-type SPR or fiber-optic SPR alone, and can not meet the detection technology deficiency of large number of samples and large differences in concentration composition, and provide an online detection system with trace samples. The surface plasmon resonance spectrometer with automatic purification function and multi-mode conduction components combined with prism and optical fiber sensing has the characteristics of ultra-sensitivity, high-throughput, and low-cost detection. The instrument has a high degree of modularization and strong portability of sensing elements.

Method used

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  • On-line purified multimode conduction surface plasma resonance spectrometer
  • On-line purified multimode conduction surface plasma resonance spectrometer
  • On-line purified multimode conduction surface plasma resonance spectrometer

Examples

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Embodiment 1

[0025] See attached figure 1 As shown, an online purification multi-mode conduction surface plasmon resonance spectrometer includes an automatic sampling system 6, a micro-membrane dialysis system 9, a multi-mode conduction detection system 13, a microfluid processing system 10, a signal processing system 12, and automatic control System 14. The front end of the automatic sampling system is injection valve 3, the back end is injection interface 8, and the front end of injection valve 3 is sample transfer pump 2. Sample transfer pump 2 is responsible for the transfer of sample 1 and mobile phase transfer pump 5 in the automatic sampling system. The mobile phase 4 responsible for maintaining a stable flow rate flows over the surface of the sensor chip or the multi-probe optical fiber array 11. The mixed liquid composed of the mobile phase and the sample is delivered to the sampling interface 8 at the front end of the micro-membrane dialysis system 9 through the automatic sampling...

Embodiment 2

[0027] See figure 2 with image 3 As shown, the multi-mode conduction detection system 13 includes light sources 1311 and 1321, a prism sensing assembly 131, an optical fiber sensing assembly 132, and an optical sensor 12. The optical sensor 12 is shared by the prism sensing assembly 131 and the optical fiber sensor 132; the prism sensing assembly The light source 1311 and the optical fiber sensor component light source 1321 use halogen tungsten light source; the prism sensor component 131 is a cylindrical prism 1315, its cross section is an isosceles triangle, the bottom surface is plated with a flat metal reflective film 1316, and the waist surface is respectively plated with incident height Reflective film and outgoing high-reflection film; optical fiber sensing assembly 132 includes optical fiber sensing assembly. The light source 1321 is connected to the input end of the Y-type optical fiber coupler 1323 via the P-type polarizer 1322, and the output end of the Y-type optica...

Embodiment 3

[0029] See Figure 4 As shown, a multi-mode conduction surface plasmon resonance spectrometer terminal reflection optical fiber sensor 1326 includes a core 13262, a micro mirror 13261, a metal layer 13263, and a specific probe fixing film 13264 on the outer layer of the metal layer 13263. The light emitted from the light source 1321 of the optical fiber sensor assembly passes through the P-type polarizer, and then is transmitted from the input end of the Y-type fiber coupler to the terminal of the sensing fiber 1325. The reflective fiber surface plasma sensor 13261 is at the interface between the metal layer 13263 and the core 13262 Surface plasmon resonance occurs at the place where the resonant light is transmitted to the micro-reflecting mirror 13261 and is reflected back along the original path.

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Abstract

The invention relates to an on-line purified multimode conduction surface plasma resonance spectrometer. The plasma resonance spectrometer is characterized by comprising an automatic sample feeding system, a minitype film dislysis system, a prism type sensing system, an optical fiber type sensing system, a microfluid processing system, a signal processing system and an automatic control system, wherein the minitype film dislysis system adopts an embedded type on-line minitype film dislysis assembly, the assembly is one of a simple pressure dislysis mode, an adsorption / resolving mode and an ion dislysis mode or a combination of the three modes; a wavelength modulation manner is adopted, one of the prism type sensing system and an optical fiber type sensing system is selected according to the requirement of limited quantity of the sample detection; and a sensing element matched with an optical fiber sensing assembly is a multi-probe array, meanwhile, determination can be carried out on multiple samples or multiple components in the samples, and a special miniflow control sample cell is designed. The multimode conduction surface plasma resonance spectrometer has on-line autopurification function on micro samples, and can rapidly finish ultra-sensitive, high flux and low cost detection of mass samples.

Description

Technical field [0001] The invention relates to a high-flux and ultra-sensitive hazard factor analysis and measurement equipment, in particular to an on-line purification multi-mode conduction surface plasma resonance spectrometer. Background technique [0002] Surface Plasmon Resonance (SPR), also known as molecular interaction spectrometer, is an ultra-sensitive and rapid detection technology used in food safety, analytical chemistry, biomolecular interaction analysis, clinical diagnosis, environmental testing and other fields Presents a huge application prospect. The SPR detection process does not need to label samples, maintains molecular activity, and the detection process is convenient and fast, with high sensitivity and high precision. It is generally favored by large foreign instrument companies and has begun large-scale research and development. At present, most commercial SPRs are mainly used for basic laboratory research, especially the interaction research of biologi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/55G01N21/552
Inventor 王利兵于艳军苏荣欣
Owner 王利兵
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