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Composition for composite drug administration

A composition and drug delivery technology, applied in the directions of drug combination, non-active components of polymer compounds, and pharmaceutical formulations, can solve the problems of not being able to exert the maximum efficacy, reducing the amount of drugs, failing to achieve therapeutic effects, etc. release effect, high drug concentration, and the effect of promoting osseointegration of diabetic implants

Active Publication Date: 2014-09-03
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, placing sustained-release microspheres directly around the implant has the effect of drug burst release, and the amount of drug actually kept at the target site will decrease due to the diffusion effect and blood flow washout, so that the maximum drug effect cannot be achieved, and the drug effect cannot be achieved. best therapeutic effect

Method used

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  • Composition for composite drug administration
  • Composition for composite drug administration
  • Composition for composite drug administration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Preparation of insulin / PLA microspheres

[0031] Insulin / PLA microspheres were prepared by the double emulsion-solvent evaporation method: 100mg PLA was dissolved in 1ml of dichloromethane to make the organic phase (O), and then 0.1ml of insulin solution (30mg / ml) was added to the organic phase, Ultrasonic (190kW) forms colostrum (W / O); Colostrum is poured into 8ml concentration and is in the PVA aqueous solution of 1%, stirs under 1500rpm rotating speed and forms double emulsion (W / O / W), then pours 7mlPVA aqueous solution, puts Stir on a mechanical stirrer at a speed of 600rpm for 6-8 hours. After the methylene chloride is completely volatilized, centrifuge to collect the obtained microspheres. After washing with distilled water for several times, then collect by centrifugation, put in a Brookfield leak filter, and freeze-dry The insulin / PLA drug-loaded microspheres were obtained.

Embodiment 2

[0033] Preparation of insulin / PLGA microspheres

[0034] Insulin / PLGA microspheres were prepared by the double emulsion-solvent evaporation method: 100mg PLGA was dissolved in 1ml of dichloromethane to make the organic phase (O), and then 0.1ml of insulin solution (30mg / ml) was added to the organic phase, Ultrasonic (190kW) forms colostrum (W / O); Colostrum is poured into 8ml concentration and is in the PVA aqueous solution of 1%, stirs under 1500rpm rotating speed and forms double emulsion (W / O / W), then pours 7mlPVA aqueous solution, puts Stir on a mechanical stirrer at a speed of 600rpm for 6-8 hours. After the methylene chloride is completely volatilized, centrifuge to collect the obtained microspheres. After washing with distilled water for several times, then collect by centrifugation, put in a Brookfield leak filter, and freeze-dry The insulin / PLGA drug-loaded microspheres were obtained.

Embodiment 3

[0036] Preparation of Insulin / PLA Microspheres-Fibrin Glue Composite Administration Composition

[0037] The insulin / PLA microsphere-fibrin glue compound administration composition is compounded by insulin / PLA microsphere and fibrin glue, and the compounding ratio is 5mg:1ml.

[0038] The insulin / PLA microspheres were prepared in advance by the double emulsion-solvent evaporation method (Example 1). Fibrin glue is composed of mammalian fibrinogen freeze-dried powder, thrombin freeze-dried powder, potassium dihydrogen phosphate solution and calcium chloride solution after virus inactivation treatment. The drug composition can be configured and used on-site in diabetic implant surgery: first, the implant socket is prepared on the alveolar bone with a preparatory drill, and at the same time, the assistant dissolves the lyophilized fibrinogen powder in the potassium dihydrogen phosphate solution respectively 1. After dissolving the lyophilized thrombin powder in calcium chloride ...

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Abstract

The invention relates to a composition for composite drug administration, in particular to a composite drug administration composition containing fibrin glue and insulin / biodegradable polymer microspheres. The sustained release drug administration composition contains the insulin in effective amount, the biodegradable polymer for maintaining release, and the fibrin glue for further prolonging insulin release, reducing drug fast release and fixing the biodegradable polymer microspheres at target positions.

Description

technical field [0001] The invention relates to a composition for compound administration. Specifically, it relates to a composite drug composition containing fibrin glue and insulin / biodegradable polymer microspheres, which is used to promote the osseointegration of implants in diabetic patients. Background technique [0002] Artificial implant technology is an effective repair method for dentition defects, edentulous and maxillofacial defects, and has been widely used clinically as a mature and reliable restoration method. Implant restorations in diabetic patients often have poor initial osseointegration and a high failure rate. Diabetic patients whose condition is not well controlled are prone to implant failure. Clinical and experimental studies have shown that the weakening of bone healing ability caused by diabetes (especially in the second week after implantation) is one of the most important reasons for the delay in the time of implant osseointegration and the decli...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/28A61K47/42A61K9/10A61P5/50
Inventor 刘洪臣韩勇
Owner GENERAL HOSPITAL OF PLA