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Silicone dressing, and preparation method and use thereof

A silicone and organosilicon technology, used in pharmaceutical formulations, active ingredients of silicon compounds, and medical preparations with non-active ingredients, etc., can solve problems such as unsatisfactory treatment effects, achieve reasonable formulation, control wound infection, and promote wounds. healing effect

Active Publication Date: 2013-06-05
江苏优创生物医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Clinically, in order to inhibit various hypertrophic scars caused by burns, trauma, surgery, infection, etc. and protect various wounds caused by burns, trauma, surgery, infection, etc., control wound infection, keep the wound moist, and promote wound healing. A variety of different treatment methods and products are often used, but the existing methods and products are often unsatisfactory in terms of treatment effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A silicone dressing consisting of the following components by weight percentage:

[0027] Silicone 1~50% (eg 1%, 25%, 50%)

[0028] Silicone antibacterial agent 0.5~5% (eg 0.5%, 3%, 5%)

[0029] Matrix balance.

[0030] The molecular weight of the silicone is 200-10000, which is methyl silicone oil (or ethyl silicone oil or phenyl silicone oil or methyl hydrogen silicone oil or methyl phenyl silicone oil).

[0031] The organosilicon antibacterial agent is organosilicon guanidine salt (or organosilicon quaternary ammonium salt or flusilazole).

[0032] The dosage form of the dressing is an aerosol, and its matrix is ​​composed of ether (or petroleum ether) and Freon (or 134a); in the matrix components, the mass percentage of ether (or petroleum ether) is 20-80%, and Freon (or 134a ) The mass percentage is 20~80%.

[0033] Preparation: Mix silicone and organic silicon antibacterial agent, dissolve in ether or petroleum ether solvent, fill in aluminum cans, then fill i...

Embodiment 2

[0036] The dosage form of the dressing is a gel, and its matrix component is a mixture of 2 to 3 components of polyvinyl alcohol, hydroxyethyl cellulose, and hydroxymethyl cellulose.

[0037] When preparing:

[0038] Mix silicone with silicone antibacterial agent, dissolve in a matrix made of 2~3 ingredients of polyvinyl alcohol, hydroxyethyl cellulose, and hydroxymethyl cellulose, and fill it in a plastic tube. After irradiation disinfection, it is the finished product. When in use, apply to the surface of scars and wounds.

[0039] All the other are with embodiment 1.

Embodiment 3

[0041] The dosage form of the dressing is a cream, and its base composition is composed of the following components by weight:

[0042] Glyceryl monostearate 30~60 parts (eg 30 parts, 45 parts, 60 parts)

[0043] 80~120 parts of stearic acid (e.g. 80 parts, 100 parts, 120 parts)

[0044] 40~60 parts of white petrolatum (for example, 40 parts, 50 parts, 60 parts)

[0045] 130~180 parts of liquid paraffin (eg 130 parts, 150 parts, 180 parts)

[0046] Glycerin 80~120 parts (e.g. 80 parts, 100 parts, 120 parts)

[0047] Tween-80 120~150 parts (eg 120 parts, 135 parts, 150 parts)

[0048] Purified water 350~550 parts (eg 350 parts, 450 parts, 550 parts).

[0049] During preparation: silicone is mixed with organic silicon antibacterial agent, miscible in the matrix formed by glyceryl monostearate, stearic acid, white vaseline, liquid paraffin, glycerin, Tween-80, purified water, pour Packed in plastic tubes and sterilized by radiation, it is the finished product. When in use, ...

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PUM

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Abstract

The invention discloses silicone dressing, and a preparation method and the use thereof. The silicone dressing is prepared from silicone, an organosilicon antibacterial agent, and matrix. The silicone dressing is reasonable in formula and convenient to prepare, can effectively restrain various hyperplastic scars caused by the reasons of burn, trauma, surgery, infection and the like, protects various wound surfaces caused by the reasons of burn, trauma, surgery, infection and the like, controls wound surface infection, keeps the wound surface wet, and promotes the wound surface to heal. The effective rate achieves over 95% by validation of more than 100 clinical cases; and the bacteriostatic ability of the product on staphylococcus aureus and escherichia coli can be over 99%.

Description

technical field [0001] The invention relates to a medical dressing and its preparation method and application. Background technique [0002] Clinically, in order to inhibit various hypertrophic scars caused by burns, trauma, surgery, infection, etc. and protect various wounds caused by burns, trauma, surgery, infection, etc., control wound infection, keep the wound moist, and promote wound healing. Various treatment methods and products are often used, but the existing methods and products are often unsatisfactory in therapeutic effect. Contents of the invention [0003] The object of the present invention is to provide a silicone dressing with reasonable formula, convenient preparation and good therapeutic effect, as well as its preparation method and application. [0004] Technical solution of the present invention is: [0005] A silicone dressing is characterized in that it consists of the following ingredients in percentage by weight: [0006] Silicone 1~50% [000...

Claims

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Application Information

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IPC IPC(8): A61L15/26A61L15/44A61L15/42A61K47/34A61K31/695A61K9/12A61K9/06A61P31/02A61P17/02
CPCY02A50/30
Inventor 潘银根潘华倩
Owner 江苏优创生物医学科技有限公司
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