Plant cellulose hard empty capsule preparation method

A technology of plant cellulose and hollow capsules, which is applied in capsule delivery, medical preparations of non-active ingredients, pharmaceutical formulas, etc. It can solve the problems of large water content differences, high water loss, and low pass rate, and achieve molecular structure stability. , Sufficient dissolution rate, ensure drying effect

Active Publication Date: 2013-09-18
SHAOXING KANGKE CAPSULE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although gelatin has good properties when preparing hollow capsules, in recent years, with the frequent occurrence of foot-and-mouth disease, mad cow disease, and bird flu, the safety of gelatin has been increasingly questioned, and some quality defects of hard gelatin capsules themselves , can not meet the market demand
[0003] At present, the following problems are prone to occur in the production process of plant-based hollow capsules: if the raw material of the product has low water content (more solids), the raw material will have poor fluidity and poor homogeneity. Inconsistent and low qualified rate of finished products
If the water content of the product raw materials is increased, the fluidity of the raw materials wi

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: produce transparent colorless cellulose capsule

[0020] Take 70 parts of water and heat it in a sandwich bucket. When the water temperature rises above 70°C, take 30 parts of hypromellose (that is, 30% of the total mass of all ingredients) and slowly add it to the water, stir evenly, and wait until When the liquid temperature drops to about 60°C, add 0.5% (mass ratio) sodium lauryl sulfate and 2% (mass ratio) sodium alginate, and continue stirring. When the temperature of the solution drops below 60°C, stop stirring. Stand still for more than 1 hour, hang the preparation solution on the production line, dip it in glue, shape it, and send it to the oven. The temperature of the oven is controlled at 50-70°C and the relative humidity is 40-60%. After 3-4 hours, it is demoulded and cut According to the conventional hard capsule production process (semi-finished product inspection, fitting, printing, finished product inspection, internal packaging, outsourcing...

Embodiment 2

[0021] Embodiment 2: produce colorless transparent cellulose hard hollow capsule

[0022] Take 75 parts of water and heat it in a sandwich bucket. When the water temperature rises above 70°C, take 25 parts of hypromellose (that is, 25% of the total mass of all ingredients), slowly add it to the water, stir evenly, and wait for When the liquid temperature drops to about 60°C, add 0.3% sodium lauryl sulfate, 0.2% Tween-80 (polysorbate-80), and 1.5% agar, and continue stirring until the solution temperature drops below 60°C , stop stirring, let it stand for more than 1 hour, hang the preparation solution on the production line, dip it in glue, shape it, and send it into the oven. The temperature of the oven is controlled at 50-70°C and the relative humidity is 40-60%. After 3-4 hours, Then demoulding, cutting, and completing the follow-up work according to the conventional hard capsule production process, the resulting product is a transparent colorless cellulose hard hollow caps...

Embodiment 3

[0023] Embodiment 3: produce colored light-shielding cellulose should empty capsule

[0024] Take 75 parts of water and heat it in a sandwich bucket. When the water temperature rises above 70°C, take 25 parts of hypromellose (that is, 25% of the total mass of all ingredients), slowly add it to the water, stir evenly, and wait for When the liquid temperature drops to about 60°C, add 0.3% sodium lauryl sulfate, 2% Tween-80 (polysorbate-80), 1.5% agar, 0.3% pigment, 1% titanium dioxide, Continue to stir, when the temperature of the solution drops below 60°C, stop stirring, let it stand for more than 1 hour, hang the preparation solution on the production line, dip it in glue, shape it, and send it to the oven, the temperature of the oven is controlled at 50-70°C, and the relative humidity is at 40-60%, after 3-4 hours, then demoulding, cutting, and follow-up work is completed according to the conventional hard capsule production process. The resulting product is a red light-shiel...

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PUM

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Abstract

The invention provides a plant cellulose hard empty capsule preparation method, and belongs to the technical field of pharmaceutical adjuvants. The plant cellulose is obtained from plant derivatives such as pine trees, purified cotton and the like. Prepared plant cellulose hard empty capsules comprise colorless and transparent hard empty capsules, colored hard empty capsules and light-shielding hard empty capsules. The preparation method comprises steps of: mixing the plant cellulose, a surfactant, a coagulant aid, a coloring agent and water, forming and drying. The plant cellulose hard empty capsule has performance stability, low water content and no interference with human body metabolism, and is green, environment-friendly, safe and suitable for being filled with various contents.

Description

technical field [0001] The invention relates to a preparation method of plant cellulose hard hollow capsules, belonging to the technical field of pharmaceutical excipients. Background technique [0002] The hard hollow capsule shell is the main outer packaging material for filling medicine and health food, and it is taken into the body together with the endocytosis, which reduces the trouble of entrance and increases the curative effect. Traditional gelatin capsules use gelatin hydrolyzed from animal skin and bone as the main raw material. Although gelatin has good properties when preparing hollow capsules, in recent years, with the frequent occurrence of foot-and-mouth disease, mad cow disease, and bird flu, the safety of gelatin has been increasingly questioned, and some quality defects of hard gelatin capsules themselves , can not meet the needs of the market. [0003] At present, the following problems are prone to occur in the production process of plant-based hollow ...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/38
Inventor 俞愈潘强明
Owner SHAOXING KANGKE CAPSULE
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