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Temperature sensitive polymer material with biodegradability and biocompatibility and preparation method thereof

A technology of biocompatibility and polymer materials, which is applied in the field of biodegradable and biocompatible temperature-sensitive polymers and their preparation, can solve the problem of not taking into account the biodegradability and biocompatibility of polymer materials Sexual temperature-sensitive properties, inability to obtain biodegradability, biocompatibility, lack of biocompatibility and other problems, to achieve good biodegradability and biocompatibility, excellent temperature-sensitive properties, to avoid the effect of reducing or disappearing temperature-sensitive properties

Inactive Publication Date: 2013-09-25
HEBEI UNIVERSITY
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  • Abstract
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AI Technical Summary

Problems solved by technology

Through the above modification method, the biodegradability and compatibility of temperature-sensitive polymer materials can be improved or improved to a certain extent, but it brings two important technical problems that are difficult to solve: first, due to the carbon chain type temperature-sensitive In the presence of polymers, the modified material itself still cannot be completely degraded, nor does it have the best biocompatibility; second, because of the introduction of non-temperature-sensitive natural polymers, the temperature-sensitive properties of the modified material are also will decrease or even disappear completely with the increase of natural polymer content
Therefore, polymer materials with good biodegradability, biocompatibility, and good temperature-sensitive properties cannot be obtained through the modification method of carbon-chain thermosensitive polymers and natural polymers.
In other words, this modification method cannot take into account the biodegradability, biocompatibility, and temperature-sensitive properties of polymer materials, making these three properties optimal

Method used

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  • Temperature sensitive polymer material with biodegradability and biocompatibility and preparation method thereof
  • Temperature sensitive polymer material with biodegradability and biocompatibility and preparation method thereof
  • Temperature sensitive polymer material with biodegradability and biocompatibility and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1: the preparation of poly(lysine methyl ester-diacetoxy tartaric acid)

[0045] (1) Preparation of 2,3‐diacetoxytartaric acid chloride

[0046] Add 20 g of tartaric acid and 44 ml of acetic anhydride into a round bottom flask, heat in an oil bath to 140° C., reflux for 2 h, and confirm the completion of the reaction by TLC to obtain a light yellow liquid. The light yellow liquid was cooled to crystallize the target compound. Subsequently, the crystals were washed several times with diethyl ether and dried under vacuum at 80°C to obtain 26.5 g of a white crystalline solid with a yield of 85%. Recrystallize 10 g of the crude product obtained in the previous step with a mixed solvent of acetone and petroleum ether to obtain 6.8 g of pure 2,3‐diacetoxytartaric acid, with a yield of 68%. The reaction equation is as follows:

[0047]

[0048] Add 2g of 2,3-diacetoxytartaric acid and 10ml of thionyl chloride into a 100ml single-necked bottle, and add two drop...

Embodiment 2

[0062] Embodiment 2: the preparation of poly(ethyl lysine-diacetoxy tartaric acid)

[0063] (1) Preparation of 2,3‐diacetoxytartaric acid chloride

[0064] The preparation of 2,3-diacetoxy tartaric acid chloride is the same as in Example 1.

[0065] (2) Synthesis of lysine ethyl ester hydrochloride

[0066] Add 150ml of ethanol to the four-neck bottle, add 21.60ml of thionyl chloride dropwise under the condition of stirring at -10°C, and continue to react for 1h after dropping for about 1.5h. Naturally rise to room temperature to obtain 150 ml of 2 mol / l HCl ethanol solution. Transfer the above solution to a brown reagent bottle, seal it and keep it away from light for later use.

[0067] Add 50ml of ethanol to the four-neck bottle, and slowly add 12ml of thionyl chloride dropwise under the condition of stirring at -10°C. The dropping time is about 20min, and the stirring is continued for 1h after the dropping is completed. Add 5 g of lysine hydrochloride and heat to reflu...

Embodiment 3

[0077] Embodiment 3: the preparation of poly(lysine methyl ester-diethoxytartaric acid)

[0078] (1) Preparation of 2,3‐diethoxytartaric acid chloride

[0079] 4.6g of sodium tartrate and 10ml of ethyl bromide under the action of 0.2g of sodium hydride (or sodium amide) as a catalyst to obtain 2,3-diethoxydiethyl tartrate, the resulting product is acidified and hydrolyzed with dilute hydrochloric acid for 3 hours to obtain 2,3‐diethoxytartaric acid. 2,3-diethoxy tartaric acid was refluxed with thionyl chloride under the catalysis of DMF for 1.5h. After separation and purification, 2,3-diethoxy tartaric acid chloride monomer was obtained with a yield of 45 %.

[0080]

[0081] (2) Synthesis of lysine methyl ester hydrochloride

[0082] The synthetic method of lysine methyl ester hydrochloride is with embodiment 1.

[0083] (3) Preparation of thermosensitive poly(lysine methyl ester‐diethoxy tartaric acid)

[0084] Add 10ml of methanol into the reaction bottle, and cool ...

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Abstract

The invention discloses a temperature sensitive polymer material with biodegradability and biocompatibility. A preparation method of the material comprises the following steps of: firstly synthesizing monomers with specific structures by using the basic raw materials including lysine, tartaric acid, and malic acid, and carrying out polymerization reaction on the monomers with different ingredients to prepare the heterochain type polymer material. The polymer not only has good temperature sensitivity, but also has good biodegradability and biocompatibility. The preparation method disclosed by the invention is simple and easy to implement and has good industrial prospect.

Description

technical field [0001] The invention relates to a functional polymer material and a preparation method thereof, in particular to a biodegradable and biocompatible temperature-sensitive polymer and a preparation method thereof. Background technique [0002] Temperature-sensitive polymers, also known as temperature-sensitive polymers, are a class of polymer materials that can respond to subtle temperature changes in the external environment, resulting in corresponding changes or even mutations in physical structure and chemical properties. Temperature-sensitive polymers exhibit unusual temperature responsiveness in aqueous solutions: when the temperature of the polymer aqueous solution rises above a certain temperature, the polymer aqueous solution appears turbid; when the temperature falls below this temperature, the solution returns to colorless Transparent. At this time, the temperature at which the phase transition of the polymer aqueous solution occurs is called the lowe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G69/26C08G69/28C08L77/06
Inventor 邓奎林李春秀靳文惠沈慧娟凡雪迎王梦马新荻颖颖
Owner HEBEI UNIVERSITY
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