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Artificial lens with differently modified front and rear ultraviolet irradiation surfaces, and preparation method thereof

A technology of intraocular lens and front and rear surfaces, applied in prosthetics, medical science, etc., can solve the problems of not being able to alleviate the complications related to the front surface, unfavorable for large-scale production, weakening complications, etc., to achieve inhibition of cell adhesion, cell adhesion Improve and reduce the effect of complications

Active Publication Date: 2013-10-09
SECOND AFFILIATED HOSPITAL ZHEJIANG UNIV COLLEGE OF MEDICINE
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Chinese Patent No. 03129204.6 discloses "A Hydrophobic Intraocular Lens with Hydrophilic Front Surface and Its Manufacturing Method", by modifying the front surface of the hydrophobic silicone gel lens optics, the hydrophilic polyethylene glycol Grafted on the front surface of the optical part of the lens to combine the advantages of the existing hydrophilic and hydrophobic intraocular lenses and remove their disadvantages, greatly reducing postoperative complications; but the intraocular lens is grafted with plasma, stable Poor performance, the back surface needs to be shielded during the manufacturing process, the operation is more complicated, and it is not conducive to mass production
However, this approach does not alleviate anterior surface-related complications

Method used

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  • Artificial lens with differently modified front and rear ultraviolet irradiation surfaces, and preparation method thereof
  • Artificial lens with differently modified front and rear ultraviolet irradiation surfaces, and preparation method thereof
  • Artificial lens with differently modified front and rear ultraviolet irradiation surfaces, and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0027] Before manufacturing the soft intraocular lens with double-surface modification, first select the manufacturing material of the intraocular lens and the modified material on its surface. High pressure sterilization, no biodegradation, so that the intraocular lens is soft, flexible, and can be bent and compressed so that it can be implanted in the eye with a small incision, and the postoperative astigmatism is small and the recovery is fast; in addition, its specific gravity is required to be small, It is not easy to crush the iris, can reduce the rupture of the zonular ligament of the intraocular lens and the subsequent dislocation, and the potential complications caused by contact with the uveal tissue, and its safety and reliability should be recognized in clinical use. According to these requirements, this embodiment uses hydrophobic soft materials, such as silicone gel, hydrophobic acrylate, etc., and takes hydrophobic acrylate as an example to make an intraocular le...

Embodiment 2

[0039] The manufacturing method of the double-surface-modified soft intraocular lens irradiated with ultraviolet light in this example adopts a different free radical initiation method from Example 1: spraying an ethanol solution of benzophenone (BP) on the front surface of the intraocular lens , after the solvent evaporates, the aqueous solution of the phospholipid monomer is coated on the front surface of the intraocular lens, and the intraocular lens is put into the ultraviolet light generator in Example 1 to accept ultraviolet light irradiation for 1-20min, so that the phospholipid monomer is grafted on the Hydrophobic soft acrylate intraocular lens surface; irradiated and then soaked in triple distilled water for 72 hours to remove unpolymerized phospholipid monomers, and finally vacuum-dried, and sealed and packaged after drying. In the ethanol solution of benzophenone (BP): the volume fraction of benzophenone is 10%.

[0040] After measurement, the modification effect o...

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Abstract

The invention relates to an artificial lens with differently modified front and rear ultraviolet irradiation surfaces, and a preparation method thereof, and aims at providing the artificial lens and the method. The front surface of the provided artificial lens has low-adhesion characteristics of phospholipid modification; the rear surface has high-adhesion characteristics of active groups; the method has the characteristics of being convenient to manufacture and low in cost. The technical scheme adopted in the invention is that the artificial lens with differently modified front and rear ultraviolet irradiation surfaces comprises a lens optical section. The artificial lens is characterized in that a phospholipid monomer molecule layer is formed at the front surface of the lens optical section; an active group layer is formed at the rear surface. The preparation method comprises the following steps of: firstly, preparing the artificial lens, providing a certain quantity of radicals at the surface of the artificial lens; evenly coating phospholipid solution at the front surface of the artificial lens, and putting into an ultraviolet generator to evenly irradiate the front and rear surfaces of the artificial lens; taking out from the ultraviolet generator after irradiation is finished, soaking and washing for 48-96 hours in three-steamed water; finally carrying out vacuum drying and sealed packaging.

Description

technical field [0001] The present invention relates to a soft and foldable intraocular lens for replacing the intraocular lens in small incision phacoemulsification cataract extraction, and a method for surface modification of the intraocular lens by ultraviolet light irradiation to produce a biocompatible It is a soft intraocular lens with good performance and the front and back surfaces can reduce postoperative complications. Background technique [0002] The phacoemulsification surgery developed in modern times has gradually replaced extracapsular cataract extraction as the mainstream cataract surgery due to its advantages of less postoperative astigmatism, less tissue damage, and faster visual recovery; Because it does not need to enlarge the incision after phacoemulsification, it can be implanted directly from the incision with a diameter of 3 mm, so it has become the development trend of intraocular lens implantation in cataract surgery. Hydrophobic materials such as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16
Inventor 黄晓丹李和一姚克
Owner SECOND AFFILIATED HOSPITAL ZHEJIANG UNIV COLLEGE OF MEDICINE
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