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Metal composite material capable of inducing bone growth and application thereof

A metal composite material and bone growth technology, which can be used in medical science, prosthesis, etc., can solve the problem of low biological activity, and achieve the effect of high biological activity, good mechanical properties, and good biological fixation.

Active Publication Date: 2013-10-23
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problem of low bioactivity of current medical metal implant devices, combine the good bioactivity of magnesium and magnesium alloys, better osteoinductive performance and the advantages of absorbable degradation, to provide a bone-guiding Metal composite materials and their applications

Method used

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  • Metal composite material capable of inducing bone growth and application thereof
  • Metal composite material capable of inducing bone growth and application thereof
  • Metal composite material capable of inducing bone growth and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Using electron beam melting rapid prototyping technology to prepare the size of Cylindrical porous titanium alloy (Ti6Al4V) scaffold, whose morphology is as follows figure 1 shown. The average pore diameter of the above-mentioned scaffold is 600 μm, and the porosity is about 60%. The bracket has a honeycomb-like structure, and the holes communicate with each other and penetrate through the outer surface of the bracket, and have three-dimensional connectivity. Then, pure magnesium (purity: 99.99%) is filled into the pores of the above-mentioned porous titanium alloy bracket by an infiltration method to form a dual-phase composite material. figure 2 That is, the microscopic morphology of the interface of the formed dual-phase composite material. It can be seen that the interface between pure magnesium and the porous titanium alloy scaffold has no defects such as voids, and the pure magnesium is completely filled in the three-dimensional pores of the porous titanium al...

Embodiment 2

[0027] Porous 317L stainless steel samples with porosities of 58% and 70% were obtained by slurry foaming method. The porous stainless steel has a three-dimensional network structure with strong penetration and uniform pore distribution. The pore diameter is 40-250 μm, and the compressive strength is respectively 189MPa and 59MPa. The Mg-0.5Ca alloy is filled into the porous stainless steel samples with two porosities mentioned above to form a two-phase composite material with two pore structures by means of melt infiltration. The compressive strengths of these two composite materials increased from 189MPa and 59MPa of porous stainless steel to 380MPa and 283MPa, respectively. It can be seen that the filling of Mg-Ca alloy is beneficial to the improvement of the mechanical properties of porous materials. After the above-mentioned composite material was cultured in simulated body fluid for 5 days, calcium phosphate was found deposited on the surface, showing good biological act...

Embodiment 3

[0029] The size is prepared by laser drilling technology: 5×5×5mm 3 , a cobalt-based alloy (Co62Cr28Mo6) with a porosity of 75% and a pore diameter of 400-600 μm, and then using an infiltration method to fill the pores of the porous cobalt-based alloy with Mg-6Zn alloy to form a composite material. The compressive strength of the composite material is 232±5MPa, which is greater than the natural bone strength of the human body, and can also meet the mechanical performance requirements of the implant.

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Abstract

The invention discloses a metal composite material capable of inducing bone growth and an application thereof. The metal composite material is especially suitable for biomedical engineering for human hard tissue defect, comprising an artificial joint, artificial bone, a dental implant, a plastic surgery medical apparatus and instrument, a bone marrow cavity implant and the like. Specifically a double-phase composite material capable of inducing bone growth is provided, a cellular structure is prepared on a clinical medical metal material (titanium, titanium alloy, stainless steel, cobalt-base alloy, nickel-titanium shape memory alloy and the like), magnesium or a magnesium alloy capable of inducing bone growth is filled in the cellular structure, and the composite material in the structure can be used as a solid material, and as the surface / partial structure of a solid metal material. By virtue of the design of the composite material, the bioactivity of an existing medical metal implantable device can be improved; along with the continuous decomposition and bone induction effect of the magnesium or the magnesium alloy in a human body environment, and the bone structure is gradually induced to grow into the cellular structure to enhance the binding strength of the bone tissue with the implant so as to prevent the implant from getting separated, achieve good biological immobilization, and greatly improve the bone integration effect.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, in particular to a metal composite material capable of guiding bone growth and its application. Background technique [0002] At present, the commonly used medical metal materials include: pure titanium, titanium alloy, stainless steel, cobalt-based alloy, nickel-titanium shape memory alloy. Medical metal materials have been a large and widely used biomedical material in clinical practice due to their excellent properties such as high strength, toughness, fatigue resistance, easy processing and high reliability in clinical use. In the medical field of hard tissues such as bones and teeth. The medical metal materials currently used in clinical applications meet certain biocompatibility requirements due to their relatively stable chemical properties, and can withstand specific loads in the body and remain permanently or semi-permanently. These metal materials are generally biological...

Claims

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Application Information

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IPC IPC(8): A61L27/04
Inventor 谭丽丽甘俊杰杨柯
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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