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Method for preparing slow-release type dressing with micro-nano bionic structure

A slow-release, micro-nano technology, applied in medical science, non-woven fabrics, absorbent pads, etc., can solve the lack of effective, fast and convenient treatment drugs and methods for the treatment of skin defect wounds, cumbersome and restrictive analgesic and antibacterial operations. Dressing application and other issues, to achieve the effect of reducing treatment time, good biocompatibility, and easy operation

Active Publication Date: 2015-02-04
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, there is a lack of effective, rapid and convenient treatment drugs and methods for the treatment of acute war wound skin defect wounds. The electronic bandages, biological bandages and other dressings developed abroad for the healing of war wounds are all due to the lack of effective wound healing, sedative Defects such as anti-pain and antibacterial and cumbersome operation restrict the application of these dressings in field first aid

Method used

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  • Method for preparing slow-release type dressing with micro-nano bionic structure
  • Method for preparing slow-release type dressing with micro-nano bionic structure
  • Method for preparing slow-release type dressing with micro-nano bionic structure

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Embodiment 1: the method for preparing micro-nano structure gel-nanofiber composite film dressing

[0058] (1) Preparation of three stock solutions:

[0059] Use ultrapure water to mix and dissolve the above silk fibroin mother solution, human epidermal growth factor, and fibroblast growth factor, and use 0.1mol / l citric acid-sodium hydroxide-hydrochloric acid buffer to adjust the pH value of the silk fibroin mother solution Go to 6.9 to prepare the electrospinning precursor solution, in which the mass percent concentration of silk fibroin is 20%, and the mass percent concentrations of human epidermal growth factor and fibroblast growth factor are 100ppm respectively.

[0060] Dissolve chitosan and rectorite particles in ultrapure water and vigorously stir in a water bath at 60°C for 24 hours to obtain CS-REC nanocomposites, wherein the mass percent concentration ratio of chitosan and rectorite is 12:1, Slowly add the prepared calcium chloride aqueous solution (0.5mg / m...

Embodiment 2

[0066] Embodiment 2: the method for preparing micro-nano structure gel-nanofiber composite film dressing

[0067] (1) Preparation of three stock solutions:

[0068] Use 0.1mol / l citric acid-sodium hydroxide-hydrochloric acid buffer to adjust the pH value of the silk fibroin mother liquor to 6.0, and then use ultrapure water to mix the above silk fibroin mother liquor, human epidermal growth factor, and fibroblast growth factor Mix and dissolve to prepare an electrospinning precursor solution, wherein the mass percent concentration of silk fibroin is 20%, and the mass percent concentration of fibroblast growth factor is 200ppm.

[0069] The chitosan and rectorite particles were dissolved in ultrapure water and vigorously stirred in a water bath at 60°C for 24 hours to obtain a CS-REC nanocomposite, wherein the mass percent concentration ratio of chitosan and rectorite was 6:1. Prepare a calcium chloride aqueous solution with a concentration of 0.5 mg / ml, and after ultrasonicat...

Embodiment 3

[0075] Embodiment 3: the method for preparing micro-nano structure gel-nanofiber composite film dressing

[0076] (1) Preparation of three stock solutions:

[0077] Use 0.1mol / L citric acid-sodium hydroxide-hydrochloric acid buffer solution to adjust the pH value of the silk fibroin mother solution to 6.9, and then use ultrapure water to mix the above silk fibroin mother solution, human epidermal growth factor, and fibroblast growth factor The electrospinning precursor solution was prepared by mixing and dissolving, wherein the mass percentage concentration of silk fibroin was 20%, and the mass percentage concentrations of human epidermal growth factor and fibroblast growth factor were 100ppm respectively.

[0078] Dissolve chitosan and rectorite particles in ultrapure water, and vigorously stir in a water bath at 60°C for 24 hours to obtain a CS-REC nanocomposite, wherein the mass percent concentration ratio of chitosan and rectorite is 12:1. Prepare a calcium chloride aqueo...

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Abstract

The invention provides a method and equipment for preparing slow-release type dressing with a micro-nano bionic structure. The operation is simple, the dressing can be cured into a film quickly on the wound surface to seal the wound surface, and other dressings do not need to be adopted for bandaging the wound surface, so that the treatment time is greatly reduced. Raw liquid combination for preparing the slow-release type dressing with the micro-nano bionic structure comprises three types of raw liquid existing independently before use; the equipment for preparing the slow-release type dressing with the micro-nano bionic structure comprises an injection pump device, a high-voltage power supply and a discharge electrode, wherein the injection pump device is provided with three independent cavities for respectively containing the three types of raw liquid; each of the three independent cavities is equipped with an independent injection nozzle; the injection nozzle matched with the independent cavity for containing the first type of raw liquid is a metal needle; the high-voltage power supply is connected to the metal needle by the discharge electrode; the propulsion of the first type of raw liquid and discharge of the discharge electrode form synchronous control; and the propulsion of the second type of raw liquid and the propulsion of the third type of raw liquid form synchronous control.

Description

technical field [0001] The invention belongs to the technical field of external application medicines, and in particular relates to a bionic nanometer dressing for promoting skin tissue repair and a preparation method thereof. Background technique [0002] The high-tech of modern warfare has made the injury mechanism of war injuries more complex, more serious tissue damage, high infection rate, slow wound healing, and susceptibility to the injury environment. Therefore, as a medical dressing used in the physiological environment of the human body, the raw materials used in the preparation of the dressing must be required to have excellent biocompatibility, non-toxicity, and even degradability. [0003] With the rapid development of nano-micro-materials, non-toxic, degradable, good film-forming and biocompatible natural polymer materials have received extensive attention in wound repair and artificial skin applications. Natural polymers currently used in the biomedical field...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D04H1/728A61L15/32A61L15/28A61L15/18A61L15/44
Inventor 李学拥邓晨李跃军李望舟吕晓星
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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