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Preparation method of surface coating capable of regulating degradation rate of magnesium alloy intravascular stent

A magnesium alloy blood vessel and degradation rate technology, which is applied in the field of surface coating preparation, can solve the problems of accelerating the degradation rate, erosion, and accelerating the corrosion of the magnesium alloy matrix, and achieves the effects of inhibiting degradation, simple method and reducing corrosion rate.

Active Publication Date: 2015-07-08
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commonly used polymers are mostly polymers whose degradation products are acidic, such as polylactic acid, which will make the microenvironment around the stent acidic, thus accelerating the degradation rate of the magnesium alloy matrix. CL at the coating interface - Such aggressive ions will also erode the substrate and accelerate the corrosion of the substrate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] This embodiment relates to a method for preparing a surface coating that can regulate the degradation rate of a magnesium alloy vascular stent, and the method includes the following steps:

[0030] Step 1, preparation of polymer solution: take poly-L-lactic acid (PLLA) with a molecular weight of 80,000-100,000, and dissolve it in chloroform at a ratio of 0.5% (mass percentage concentration) of the polymer solution;

[0031] Step 2, after mixing Mg powder particles (particle size of 10nm) and PLLA at a mass ratio of 0.1:100, put them into the polymer solution, and ultrasonically treat them for 3 hours, so that the Mg powder particles are evenly dispersed in the solution;

[0032] Step 3, uniformly coat the dispersion liquid on the surface of the Mg-Nd-Zn-Zr magnesium alloy vascular stent soaked in hydrofluoric acid with a mass fraction of 40% for 12 hours by dip-coating method, repeat the dip-coating after drying, and make the coated The thickness of the layer reaches 0....

Embodiment 2

[0035] This embodiment relates to a method for preparing a surface coating that can regulate the degradation rate of a magnesium alloy vascular stent, and the method includes the following steps:

[0036] Step 1, preparation of polymer solution: take polylactic acid-trimethylene carbonate copolymer (P(LA-TMC)) with a molecular weight of 80,000, and dissolve it in dichloromethane at 1% (mass percentage concentration) of the polymer solution middle;

[0037] Step 2, the Mg(OH) 2 Particles (with a particle size of 70nm) and polylactic acid-trimethylene carbonate copolymer are mixed in a mass ratio of 2:100, put into the polymer solution, and ultrasonically treated for 0.5h to make Mg(OH) 2 The particles are completely dispersed;

[0038] Step 3, uniformly coat the dispersion liquid on the surface of the Mg-Nd-Zn-Zr magnesium alloy vascular stent soaked in hydrofluoric acid with a mass fraction of 20% for 40 hours by dip-coating method, repeat the dip-coating after drying, and m...

Embodiment 3

[0041] This embodiment relates to a method for preparing a surface coating that can regulate the degradation rate of a magnesium alloy vascular stent, and the method includes the following steps:

[0042] Step 1, the preparation of polymer solution: take the polytrimethylene carbonate (PTMC) that molecular weight is 100000, be dissolved in methylene chloride as 5% (mass percentage concentration) by polymer solution;

[0043] Step 2, mix MgO particles (particle size 10um) with PTMC at a mass ratio of 10:100, put them into the polymer solution, and ultrasonically treat them for 24 hours to disperse the MgO particles evenly;

[0044] Step 3, using the dip coating method to evenly coat the dispersion on the surface of the Mg-Nd-Zn-Zr magnesium alloy vascular stent soaked in hydrofluoric acid with a mass fraction of 30% for 96 hours, so that the coating thickness reaches about 50 μm, After natural drying in the air for 2 hours, vacuum drying at 40° C. for 12 hours, a magnesium allo...

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Abstract

The invention relates to a preparation method of a surface coating capable of regulating the degradation rate of a magnesium alloy intravascular stent. The preparation method comprises the following steps: step one, preparing a polymer solution : dissolving biodegradable high polymer material into organic solvent; step two: preparing dispersion liquid containing an additive: adding additive particles into the polymer solution, and performing ultrasonic dispersion; step 3: coating the dispersion liquid containing the additive on the surface of the biodegradable magnesium alloy intravascular stent by adopting a dip coating method or a spraying method so as to form a coating, and obtaining the surface coating after the coating is dried and baked. The coating containing the additive, which is prepared through the preparation method provided by the invention, has the advantages that acidic micro-environment at the periphery of the coating can be improved, the degradation of a basal body is inhibited, the basal body together with the coating is completely degraded in a human body finally, the side effects to human body are not be generated, meanwhile, the degradation speed of the coating can be controlled through regulating the content of the additive. Therefore, the degradation speed of the intravascular stent can be controlled.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, in particular to a method for preparing a surface coating capable of regulating the degradation rate of a magnesium alloy vascular stent. Background technique [0002] Interventional vascular stent therapy is the most important means in the field of cardiovascular disease treatment. Compared with the permanent vascular stents such as stainless steel, cobalt-chromium alloy and nickel-titanium alloy currently used clinically, the degradable magnesium alloy vascular stent has outstanding advantages, including (1) degradable and will not cause permanent irritation to the vessel wall, It will not cause adverse reactions such as intimal hyperplasia after long-term implantation of permanent vascular stents; (2) It has good histocompatibility and biocompatibility. As an essential trace element for the human body, magnesium is not toxic to the human body and will not Because the release of ions trig...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10A61L31/08A61L31/14
Inventor 郭圣荣袁广银史永娟沈燕箐
Owner SHANGHAI JIAOTONG UNIV
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