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Scar treatment external application western medicine composition preparation and application thereof

A technology of composition and preparation, which is applied in the field of external western medicine composition preparation, can solve the problems of short curative effect time of scars, achieve remarkable curative effect, overcome poor curative effect, and have broad application prospects

Inactive Publication Date: 2013-12-11
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Up to now, the inventors have proposed acetylsalicylic acid and captopril as a western medicine composition for external use, which can be used to treat scars with remarkable curative effect and short time, and at the same time, it can effectively treat scars. There are no relevant literature and patent literature reports on externally applied western medicine composition preparations with anti-inflammatory, antipruritic and analgesic effects

Method used

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  • Scar treatment external application western medicine composition preparation and application thereof
  • Scar treatment external application western medicine composition preparation and application thereof
  • Scar treatment external application western medicine composition preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The clinical treatment of embodiment 1 wound and burn scar patient

[0035] The experimental subjects were 62 patients with scars, including 36 cases after general surgery, 16 cases after trauma and 10 cases after burn. There were 46 males and 16 females, aged 14-50 years. The scar sites were face, neck, chest, abdomen and upper and lower extremities.

[0036]Test method 62 patients were randomly divided into a test group of 32 cases and an asiaticoside ointment group of 30 cases. 5% acetylsalicylic acid and 10% captopril topical western medicine composition cream were used to smear wounds on the scar parts of patients in the test group, asiaticoside ointment was used to smear wounds on the scar parts of patients in the asiaticoside ointment group, and asiaticoside ointment was used to smear the wounds of the patients in the two groups 3 times / day, 6-100mg / cm each time 2 , Wash the wound with normal saline every other day for 4-12 weeks, observe and record the wound ...

Embodiment 2

[0043] Embodiment 2 mouse skin cut and burn experiment

[0044] Experimental animals: Clean grade male Kunming mice 18-22g.

[0045] The test grouping was randomly divided into 4 groups, test A1 group (shear group), test A2 group (burn group), natural healing control group (B group), positive drug control group (C group, asiaticoside ointment group), each 10 in each group.

[0046] Test method The mice in test A1 group, test A2 group, natural healing control group and positive drug control group were under ether anesthesia, and the test A1 group used surgical scissors to cut off the skin with a size of 5×5 cm on the back of the mice. In the test group A2, a hot iron (1.5cm×1.5cm, 100° C., 5 seconds) was used to burn the skin of 5×5 cm on the back of the mouse. Natural healing control group, positive drug control group, 5 mice were burned and cut in each group. 5% acetylsalicylic acid and 10% captopril topical western medicine composition emulsifiable cream were used for tes...

Embodiment 3

[0049] Embodiment 3 cicatrix and keloid cause the treatment of inflammation, pruritus and pain

[0050] The experimental subjects were 60 patients with inflammation, itching and pain caused by scars, including 38 cases after surgery, 14 cases after trauma and 8 cases after burns. There were 44 males and 16 females, aged 18-50 years. The scar sites were face, neck, chest, abdomen and upper and lower extremities respectively.

[0051] Test method 60 patients were randomly divided into a test group of 30 cases and an asiaticoside ointment group of 30 cases. 5% acetylsalicylic acid and 10% captopril topical western medicine composition cream were used to smear the wounds on the scar parts of the patients in the test group, and asiaticoside ointment was used to smear the wounds on the scar parts of the patients in the asiaticoside ointment group, and the wounds of the two groups were smeared 3 times / day, 6-100mg / cm each time 2 , Wash the wound with normal saline every other day ...

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Abstract

The present invention relates to an external application western medicine composition preparation with functions of scar treatment, anti-inflammation, itching relieving and pain relieving, and an application thereof. The external application western medicine composition preparation comprises a medicine active ingredient and a pharmaceutically acceptable auxiliary material, wherein the medicine active ingredient mainly comprises 3-10% of acetylsalicylic acid and 8-15% of captopril. According to the present invention, the conventional preparation process is adopted to prepare different external application formulations in the clinic; pharmacodynamics experiment results show that: skin wound fibroblast proliferation is significantly inhibited, collagen fiber content is reduced, skin growth is promoted, and effects of anti-inflammation, itching relieving and pain relieving are provided; and the external application western medicine composition preparation has characteristics of synergetic effect of the compound medicine, significant treatment effect, low price and simple preparation, is a safe and effective skin scar treatment medicine, and has broad application prospects.

Description

technical field [0001] The invention relates to an externally used western medicine composition preparation for treating scars and having anti-inflammatory, antipruritic and analgesic effects on the affected area. The active ingredients of the externally used western medicine composition preparation are mainly acetylsalicylic acid, captopril and pharmaceutical Composition of acceptable excipients. Background technique [0002] Scar is a pathological phenomenon of abnormal proliferation of fibroblasts and excessive proliferation of collagen fibers in the process of skin wound healing. Hypertrophic scars are pathological scars, and the incidence of hypertrophic scars is high. It not only destroys the beauty of the body surface, but also causes redness, swelling, and intense itching in the local tissue of the scar. And severe pain, but also hinder the function of related tissues or organs, and even lead to deformity. With the continuous improvement of people's living standards...

Claims

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Application Information

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IPC IPC(8): A61K31/616A61P17/02A61P29/00A61P17/04A61K31/401
Inventor 贺弋王菲周永忠陶虹
Owner NINGXIA MEDICAL UNIV
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