Lutein microcapsule and preparation method thereof

A technology of lutein and microcapsules, which is applied in the pharmaceutical field, can solve the problems of low activity of microcapsules, unsatisfactory product fluidity, irregular product shape, etc. The effect of oxidation

Inactive Publication Date: 2014-02-12
中国中化股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method uses lutein oleoresin as a raw material, so the activity of the prepared microcapsules is low; in addition, this method uses ordinary spray drying for drying, which leads to irregular shape of the product and unsatisfactory product fluidity

Method used

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  • Lutein microcapsule and preparation method thereof
  • Lutein microcapsule and preparation method thereof
  • Lutein microcapsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] Lutein microcapsules were prepared from lutein crystals (90% lutein content).

[0087] Dissolve 6g of lutein crystals in 120ml of ethyl acetate, add 5g of sucrose ester, stir and heat to 70°C, stir for 30min to dissolve, and obtain the core material phase. Add 30g of gelatin, 10g of modified starch, 20g of sucrose and 5g of dextrin into 100mL of water, heat to 90°C, and stir to dissolve the gelatin. Add 8g of sodium caseinate and 3g of citric acid, stir until dissolved, and obtain the capsule material phase. The core material phase and the capsule material phase were mixed, emulsified and homogenized by a high-pressure homogenizer at 80 MPa for 0.5 hours to form an emulsion, and the particle size of the emulsion was measured by a laser particle size analyzer to reach 200 nm. After the organic solvent is recovered by the three-effect evaporator, the emulsion is sprayed-starch fluidized bed (purchased from GEA (GEA) company in Germany) and drying to obtain lutein microc...

Embodiment 2

[0094] Lutein microcapsules were prepared from lutein crystals (90% lutein content).

[0095] Dissolve 12kg of lutein crystals in 120L of dichloromethane, add 0.5kg of phospholipid, heat to 30°C, stir for 15min to dissolve, and obtain the core material phase. Add 90L of water to 35kg of gum arabic, 10kg of modified starch, 15kg of glycerin and 14kg of maltose syrup, heat to 40°C, and stir to dissolve them. Add 1 kg of casein and 0.5 kg of disodium hydrogen phosphate, stir until dissolved, and obtain the capsule material phase. The core material phase and the capsule material phase were mixed, emulsified and homogenized by a high-pressure homogenizer at 20 MPa for 0.5 hours to form an emulsion, and the particle size of the emulsion was measured by a laser particle size analyzer to reach 350 nm. Evaporate and recover the organic solvent through a three-effect evaporator to obtain a stable emulsion, and then spray the emulsion through a spray-starch fluidized bed (purchased from...

Embodiment 3

[0102] Lutein microcapsules were prepared from lutein crystals (85% lutein content).

[0103] Dissolve 18kg of lutein crystals in 200L of acetone, add 1kg of monoglyceride, heat to 50°C and stir for 15min to dissolve to obtain the core material phase. Add 85L of water to 30kg of modified starch, 20kg of sucrose, 10kg of glycerin and 5kg of dextrin, heat to 50°C, and stir to dissolve the modified starch and dextrin. Add 2.5 kg of potassium caseinate and 1.5 kg of dipotassium hydrogen phosphate, stir until dissolved, and obtain the capsule material phase. The core material phase and the capsule material phase were mixed, emulsified and homogenized by a high-pressure homogenizer at 40 MPa for 1 hour to form an emulsion, and the particle size of the emulsion was measured by a laser particle size analyzer to reach 230 nm. Evaporate and recycle the organic solvent through a three-effect evaporator to obtain a stable emulsion, and then spray the emulsion through a spray-starch fluid...

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Abstract

The invention relates to a lutein microcapsule and a preparation method thereof, wherein the lutein microcapsule consists of a core containing a lutein crystal and an oil soluble emulsifying agent, a shell covering the core, and starch grains stuck outside the shell; the shell includes a capsule material, a water soluble emulsifying agent and a stabilizing agent, wherein dosage ratio of the lutein crystal to the oil soluble emulsifying agent to the capsule material to the water soluble emulsifying agent to the stabilizing agent is (1-30): (0.5-5): (60-95): (1-8): (0.5-5) in parts by weight. The lutein microcapsule is regular in shape, relatively uniform in granularity, good in fluidity, and excellent in both stability and activity.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to lutein microcapsules and a preparation method thereof. Background technique [0002] Carotenoids are fat-soluble plant pigments widely found in nature. Carotenoids are mainly divided into two categories: carotene and lutein. Natural lutein is also known as plant "lutein". Medical experiments have proved that lutein contained in plants is an antioxidant with excellent performance. Adding a certain amount of lutein to food can prevent a series of diseases caused by cell aging and aging of body organs, such as retinal macular degeneration , cataract, colon cancer, cardiovascular sclerosis, coronary heart disease, etc. At the same time, lutein can also be used as a feed additive for the coloring of poultry meat and eggs, and it has also been used as a coloring and nutritional health agent in the food industry. However, lutein is unstable, easily oxidatively decomposed, sensiti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/047A61K47/36B82Y5/00A23L1/27A23L1/29A23K1/16A61P39/06A61P27/02A61P27/12A61P35/00A61P9/00A61P9/10A23L5/40A23L33/00
Inventor 赵伟学汪振洋张林金善亮
Owner 中国中化股份有限公司
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