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Preparation method of medical porous metal material capable of replacing weight-bearing bone tissue

A technology of porous metal and bone tissue, applied in medical science, prosthesis, etc., can solve the problems of insufficient purity of finished products, reduced biosafety, carbon skeleton residues, etc., to achieve high qualified rate of finished products, improve mechanical properties, pore distribution uniform effect

Active Publication Date: 2015-04-08
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limitations of its preparation method, the purity of the obtained finished product is not enough, and there are carbon skeleton residues, resulting in a decrease in biological safety

Method used

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  • Preparation method of medical porous metal material capable of replacing weight-bearing bone tissue
  • Preparation method of medical porous metal material capable of replacing weight-bearing bone tissue
  • Preparation method of medical porous metal material capable of replacing weight-bearing bone tissue

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Embodiment 1: Weigh zinc stearate, average particle diameter is less than 43 micron oxygen content is less than 0.1% tantalum powder and hydrogen peroxide mix uniformly, wherein zinc stearate accounts for 11%, hydrogen peroxide accounts for 18%, tantalum powder accounts for 71%, All are calculated by volume percentage. Pressure molding: Add the above mixed powder into an injection molding machine and press it into a polyurethane foam (pore diameter 0.48-0.89mm, density 0.015g / cm2) at 82Mpa 3 ~0.035g / cm 3 , hardness greater than 50°) in molding. Degreasing treatment: vacuum degree 10 -4 Pa, from room temperature to 400°C at a heating rate of 1.5°C / min, and hold for 320 minutes; then raise the temperature from 400°C to 700°C at a heating rate of 0.6°C / min, and hold for 350 minutes. Vacuum sintering: vacuum degree is 10 -4 Pa~10 -3 Pa, heat up to 1800°C at 13°C / min, hold for 200min, cool with the furnace to 200-300°C, then heat up to 1800°C at 17°C / min, hold for 230mi...

Embodiment 2

[0029] Embodiment 2: Take stearic acid, tantalum powder with an average particle diameter less than 43 microns and an oxygen content less than 0.1% and ammonium bicarbonate and mix uniformly to form a mixed powder, wherein stearic acid accounts for 12%, ammonium bicarbonate accounts for 23%, tantalum Powder accounted for 65%, all in volume percentage. Pressure molding: Add the above mixed powder into an injection molding machine and press it into a polyurethane foam (pore diameter 0.48-0.89mm, density 0.015g / cm2) at 75Mpa 3 ~0.035g / cm 3 , hardness greater than 50°) in molding. Degreasing treatment: vacuum degree 10 -4 Pa, from room temperature to 500°C at a heating rate of 0.3°C / min, and hold for 360min. Vacuum sintering: vacuum degree is 10 -3 Pa, heat up to 1500°C at 10°C / min, hold for 150min, cool with the furnace to 200-300°C, then heat up to 1600°C at 20°C / min, hold for 240min, heat up to 2000-2200°C at 10°C / min, Insulate for 120 minutes; fill the sintering process w...

Embodiment 3

[0031]Embodiment 3: Weigh paraffin wax, tantalum powder with an average particle diameter less than 43 microns and oxygen content less than 0.1%, and mix evenly with hydrogen peroxide, wherein paraffin wax accounts for 7%, hydrogen peroxide accounts for 25%, and tantalum powder accounts for 68%, all in volume percentage count. Pressure molding: Add the above mixed powder into an injection molding machine and press it into a polyurethane foam (pore diameter 0.48-0.89mm, density 0.015g / cm2) at 52Mpa 3 ~0.035g / cm 3 , hardness greater than 500) in molding. Degreasing treatment: vacuum degree 10 -4 Pa, from room temperature to 400°C at a heating rate of 2°C / min, and hold for 300min. Vacuum sintering: vacuum degree is 10 -4 Pa, heat up to 1600°C at 20°C / min, hold for 120min, cool with the furnace to 200-300°C, then heat up to 1500°C at 10°C / min, hold for 180min, heat up to 2000-2200°C at 5°C / min, Insulate for 360 minutes; fill the sintering process with argon protection, cool o...

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Abstract

The invention relates to a preparation method of a medical porous metal material capable of replacing a weight-bearing bone tissue. The method comprises the following steps: mixing tantalum powder with a pore-forming agent and a molding agent; pressing mixed powder into an organic foaming body; molding, degreasing, sintering and cooling; and performing heat treatment, wherein carrying out the degreasing under the conditions of gradually heating to 400 DEG C to 800 DEG C according to the speed rate of 0.3 DEG C / minute to 2 DEG C / minute, forming a protective atmosphere in an argon leading-in mode and carrying out the heat preservation for 300 to 360 minutes; and carrying out the sintering at 10<-4>Pa to 10<-3>Pa under the conditions of gradually heating to 1500 DEFG C to 1800 DEG C at the speed rate of 10 DEG C / minute to 20 DEG C / minute, carrying out the heat preservation for 120 to 240 minutes, cooling to 200 DEG C to 300 DEG C along with a furnace, then gradually heating to 1500 DEG C to 1800 DEG C at the speed rate of 10 DEG C / minute to 20 DEG C / minute, carrying out the heat preservation for 180 to 240 minutes, heating to 2000 DEG C to 2200 DEG C according to the speed rate of 5 DEG C / minute to 10 DEG C / minute and carrying out the heat preservation for 120 to 360 minutes. By testing, the content of impurities in the material is below 0.2%; the density of the material can reach 5.00g / cm<3> to 6.67g / cm<3>; the porosity of the material can reach 60% to 70%; the pore diameter of the material can reach 200 mu m to 400 mu m; the elasticity modulus of the material can reach 3.8Gpa to 4.2Gpa; the bending strength of the material can reach 125Mpa to 150Mpa; the compressive strength of the material can reach 72Mpa to 90Mpa. Thus, the contradiction that the medical porous metal material for replacing the weight-bearing bone tissue is required to have the large porosity and the good mechanical property is effectively solved.

Description

[0001] The application of the present invention is a divisional application with application number 201110295814.9, application date September 29, 2011, and the title of the invention "a preparation method of a medical porous metal material replacing load-bearing bone tissue". technical field [0002] The invention relates to a preparation method of a porous medical metal implant material, in particular to a preparation method of a medical porous metal implant material which replaces the bone tissue of a load-bearing part. Background technique [0003] Porous medical metal implant materials have important and special uses in the treatment of bone tissue trauma and femoral tissue necrosis. Common materials of this type include porous metal stainless steel and porous metal titanium. As a porous implant material used in the treatment of bone tissue trauma and femoral tissue necrosis, its porosity should reach 30-80%, and the pores should be all connected and evenly distributed, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C22C1/08A61L27/04A61L27/56
Inventor 叶雷
Owner CHONGQING RUNZE PHARM CO LTD
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