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Method capable of improving selenium content for preparing polysaccharide selenite

A polysaccharide selenite content technology, applied in the field of polysaccharide selenite preparation, can solve the problems of complex selenium polysaccharide synthesis process, heavy metal organic solvent pollution, low selenium content of products, etc., to avoid food safety problems, Easy post-processing and simple process flow

Active Publication Date: 2014-07-02
浙江皇冠科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The invention provides a preparation method of polysaccharide selenite with increased selenium content, which solves the problems of complicated synthetic process of selenium polysaccharide, difficult reaction control, low selenium content of products, and pollution of heavy metals, toxic gases and toxic organic solvents The problem

Method used

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  • Method capable of improving selenium content for preparing polysaccharide selenite
  • Method capable of improving selenium content for preparing polysaccharide selenite
  • Method capable of improving selenium content for preparing polysaccharide selenite

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Example 1: Preparation of starch selenite

[0035] 1) First add 33g of 100-200 mesh potato starch into the reaction vessel, spray 18g of sodium selenite solution with a concentration of 65% (mass fraction) into the reaction vessel evenly with a spray device, and keep stirring under nitrogen protection, The stirring speed was 40 rev / min, and the temperature was raised to 130° C. to carry out the esterification reaction for 18 hours;

[0036] 2) After the reaction, dissolve the reaction product with a small amount of distilled water and put it into a dialysis bag, and carry out dialysis treatment with distilled water until the solution in the dialysis bag is detected with 2% ascorbic acid and no red appears, stop dialysis, and the solution in the dialysis bag is at 60 ℃. , Concentrate under reduced pressure to 1 / 20 of the original volume under the condition of 0.09Mpa.

[0037]3) The concentrated solution was freeze-dried at -60°C and 9Pa for 24 hours to obtain starch se...

Embodiment 2

[0039] Embodiment 2: the preparation of chitosan selenite

[0040] 1) First add 100g of 50-100 mesh chitosan into the reaction vessel, and use a spray device to evenly spray 50g of selenous acid solution with a concentration of 60% (mass fraction) into the reaction vessel, and continue stirring under nitrogen protection. The stirring speed is 60 rpm, and the temperature is raised to 145°C for esterification reaction for 22 hours;

[0041] 2) After the reaction is over, dissolve the reaction product with a small amount of distilled water and put it into a dialysis bag, and perform distilled water dialysis until the solution in the dialysis bag is tested with 2% ascorbic acid and no red color appears, stop dialysis, and the solution in the dialysis bag is at 55°C , Concentrated under reduced pressure to 1 / 30 of the original volume under the condition of 0.08Mpa.

[0042] 3) The concentrated solution is spray-dried, and the inlet temperature of the spray dryer is controlled to 1...

Embodiment 3

[0044] Embodiment 3: the preparation of polysaccharide selenite

[0045] 1) First add 25g of 60-80 mesh pachyrhythm to the reaction vessel, and use a spray device to evenly spray 10g of sodium selenite solution with a concentration of 70% (mass fraction) into the reaction vessel, and continue stirring under the protection of nitrogen. The stirring speed is 30 rpm, and the temperature is raised to 120° C. for 20 hours of esterification;

[0046] 2) After the reaction is over, dissolve the reaction product with a small amount of distilled water and put it into a dialysis bag, and perform distilled water dialysis until the solution in the dialysis bag is tested with 2% ascorbic acid and no red color appears, stop dialysis, and the solution in the dialysis bag is at 55°C , Concentrated under reduced pressure to 1 / 15 of the original volume under the condition of 0.09Mpa.

[0047] 3) The concentrated solution was freeze-dried at -55°C and 6Pa for 30 hours to obtain pachyphyllin sel...

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Abstract

The invention discloses a method capable of improving selenium content for preparing polysaccharide selenite. The method comprises the steps of adding a selenium compound solution having the mass fraction of 60-80% by spraying to a polysaccharide or a polysaccharide complex under a stirring condition and reacting at a temperature in the range of 120-160 DEG C; after the reaction is completed, purifying and drying the reaction product to obtain polysaccharide selenite, wherein the selenium compound is seleninic acid or a selenite. The method is simple in process, easy in after-treatment, controllable in reaction conditions and good in repeatability; in the production process, the generation of toxic gases such as hydrogen selenide is avoided and the use of a strong acid and heavy metals such as a barium salt to catalyze the reaction and the use of toxic organic solvents such as pyridine and benzene are avoided, and therefore, the production process is green and environment-friendly; the polysaccharide selenite prepared by the method is low in toxicity and high in bioavailability, and the selenium content of the polysaccharide selenite is higher than 18% which is far higher than the selenium content of less than 2% of the present commercial organic selenium products.

Description

technical field [0001] The invention relates to the technical field of selenized polysaccharides, in particular to a preparation method of a polysaccharide selenite with increased selenium content. Background technique [0002] Selenium is an essential trace element for human life activities, and is considered by the World Health Organization as the "anti-cancer guardian" and "the patron saint of the heart" for human health. Selenium can form the active center of several oxidase in the living body, can protect the structure and function of cell membrane, enhance the body's immunity and antioxidant capacity, and play an important role in maintaining biological functions and preventing diseases. According to clinical trials, selenium has a good preventive and therapeutic effect on more than 40 human diseases such as cancer, hypertension, cataract, diabetes, anemia and Keshan disease. [0003] Selenium exists in nature in two forms: inorganic selenium and organic selenium. In...

Claims

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Application Information

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IPC IPC(8): C08B31/06C08B37/08C08B37/00
Inventor 胡向东叶茂胡伟卿潘玲燕何京
Owner 浙江皇冠科技有限公司
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