Pharmaceutical composition and its preparation

A technology of composition and medicine, which is applied in the field of medicine, can solve problems such as the easy oxidation of guanosine nucleoside, and achieve the effect of good therapeutic effect, controllable quality and clear ingredients

Inactive Publication Date: 2014-07-09
西藏博睿生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the process of our research, we found that the combination of guanosine and amino acid has obvious curative effect on cardiovascular system diseases. Purine nucleosides are prone to oxidation, and cysteine ​​is a non-essential amino acid for the human body, which has no toxic side effects on the human body

Method used

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  • Pharmaceutical composition and its preparation
  • Pharmaceutical composition and its preparation
  • Pharmaceutical composition and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] prescription:

[0062] Element

[0063] Preparation method: Take 100L of water for injection, heat to boil, vacuumize, fill with nitrogen, put in raw and auxiliary materials at a water temperature of 70°C-90°C: proline, serine, alanine, isoleucine, leucine, tyrosine , glutamic acid, phenylalanine, arginine, lysine, valine, threonine, glycine, after being completely dissolved, add sorbitol, and lower the temperature at the same time, when the temperature of the liquid drops to 60°C, add the composition Amino acid, when the temperature of the medicinal solution is lowered to 45°C, add cysteine, after it is completely dissolved, add the prescribed amount of guanosine and stir until completely dissolved, add water for injection to the specified amount, stir evenly, 0.45μm filter element, 0.22 Filter with a μm filter element, fill the filtrate into a non-PVC composite co-extruded film infusion bag under nitrogen protection, seal it, and sterilize at 115°C for 30 m...

Embodiment 2

[0065] prescription:

[0066] Element

[0067] Preparation method: Take 100L of water for injection, heat to boil, vacuumize, fill with nitrogen, put in raw and auxiliary materials at a water temperature of 70°C-90°C: proline, serine, alanine, isoleucine, leucine, aspartic acid Acid, tyrosine, glutamic acid, phenylalanine, arginine, lysine, valine, threonine, glycine, after being completely dissolved, add sorbitol, and cool down at the same time, until the temperature of the liquid drops to 60 ℃, add histidine, and when the temperature of the liquid drops to 45 ℃, add cysteine, and after it is completely dissolved, add the prescribed amount of guanosine and stir until completely dissolved, add water for injection to the specified amount, and stir evenly. Filter with a 0.45 μm filter element and a 0.22 μm filter element, fill the filtrate into a non-PVC composite co-extruded film infusion bag under nitrogen protection, seal it, and sterilize at 115°C for 30 minutes t...

Embodiment 3

[0069] prescription:

[0070] Element

[0071] Preparation method: Take 100L of water for injection, heat to boil, vacuumize, fill with nitrogen, put in raw and auxiliary materials at a water temperature of 70°C-90°C: proline, serine, alanine, isoleucine, leucine, aspartic acid Acid, tyrosine, glutamic acid, phenylalanine, arginine, lysine, valine, threonine, glycine, cystine, add sorbitol after completely dissolved, cool down at the same time, wait for the drug When the temperature of the liquid drops to 60°C, add histidine, when the liquid temperature drops to 45°C, add cysteine, add the prescribed amount of guanosine and stir until completely dissolved, add water for injection to the specified amount , stir evenly, filter with a 0.45 μm filter element and a 0.22 μm filter element, fill the filtrate into a non-PVC composite co-extruded film infusion bag under nitrogen protection, seal it, and sterilize at 115°C for 30 minutes to obtain the product.

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Abstract

The invention belongs to the medicine technical field, and relates to a pharmaceutical composition and a preparation. The pharmaceutical composition comprises amino acid and guanosine hydrate. According to the pharmaceutical composition, the component is clear and the quality is controllable; the pharmaceutical composition can be used for preparing an injection or a freeze-dried powder administration preparation; the pharmaceutical composition has good treatment effect for coronary heart disease and angina pectoris, and is adapted to clinically wide application.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition and preparation containing guanosine and amino acids. Background technique [0002] Cardiovascular disease is a disease with high morbidity, high mortality and high disability rate in human beings. It is extremely harmful to the human body. A large amount of research data shows that cardiovascular disease is a chronic disease caused by many risk factors, including genetic factors, hypertension, hyperlipidemia, diabetes, smoking and bad living habits, among which dyslipidemia is one of the most important risk factors. Dyslipidemia usually includes elevated triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and low high-density lipoprotein cholesterol (HDL-C). The damage of dyslipidemia to the body is hidden, progressive and systemic. Most patients with early hyperlipidemia have no obvious clinical sym...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/708A61K31/4172A61K31/401A61K31/198A61K31/195A61P9/10A61P3/06A61P7/02
Inventor 曹捷高帆周战尚磊
Owner 西藏博睿生物科技有限公司
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