Preparation method of ellipsoidal ion-doped hydroxyapatite microspheres with porous surface

A technology of hydroxyapatite and ion doping, applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., can solve problems that are not conducive to the biomedical application of HA microsphere materials, achieve high specific surface area, and simple preparation method Controllable, inexpensive to prepare effects

Active Publication Date: 2015-11-04
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The template method can control the shape and size of microspheres, and can obtain uniform HA materials. Researchers usually use organic polymer materials or inorganic materials that are easy to form spheres as shape regulators to regulate the shape of HA; commonly used Organic polymer materials include β-cyclodextrin, cyclohexane, cetyltriethylammonium bromide, ethylenediaminetetraacetic acid amine, polyethylene glycol, etc., but the HA microspheres obtained by this method remain A large number of toxic templates, organic solvents, surfactants, etc., are not conducive to the biomedical application of the HA microsphere material; compounds such as lithium borate, polymethyl methacrylate, and calcium carbonate have physical and chemical properties that are easy to form balls, usually Used as the precursor of HA microsphere material

Method used

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  • Preparation method of ellipsoidal ion-doped hydroxyapatite microspheres with porous surface
  • Preparation method of ellipsoidal ion-doped hydroxyapatite microspheres with porous surface
  • Preparation method of ellipsoidal ion-doped hydroxyapatite microspheres with porous surface

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Experimental program
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Effect test

Embodiment 1

[0041] 1. Preparation of Ellipsoidal Calcium Carbonate Microspheres

[0042] (1). Weigh an appropriate amount of calcium nitrate, dissolve it in deionized water, and carry out mechanical stirring for 1 week at 0°C to prepare a 2mol / L calcium nitrate solution;

[0043] (2). Weigh an appropriate amount of sodium carbonate, dissolve it in deionized water, and carry out mechanical stirring for 1 week at 0°C to prepare a 2mol / L sodium carbonate solution;

[0044] (3). Adjusting the reaction temperature to be 0°C, the reaction temperature is 0°C and under the mechanical stirring condition of 3000rpm at the stirring speed, the calcium nitrate solution obtained in step (1) is quickly added to the step (2L / min) with a speed of 2L / min 2) in the sodium carbonate solution obtained; after reacting for 1 week, filter and wash to obtain ellipsoidal calcium carbonate microspheres;

[0045] 2. Preparation of ellipsoidal ion-doped HA

[0046] (a). Weigh an appropriate amount of diammonium hyd...

Embodiment 2

[0051] 1. Preparation of Ellipsoidal Calcium Carbonate Microspheres

[0052] (1). Weigh an appropriate amount of calcium chloride, dissolve it in deionized water, and carry out mechanical stirring for 6 hours at -3°C to prepare a 1mol / L calcium chloride solution;

[0053] (2). Weigh an appropriate amount of potassium carbonate, dissolve it in deionized water, and carry out mechanical stirring for 6 hours at -3°C to prepare a 1mol / L potassium carbonate solution;

[0054] (3).Regulate the reaction temperature to be -3°C. Under the mechanical stirring condition that the reaction temperature is -3°C and the stirring speed is 2000rpm, the calcium chloride solution obtained in step (1) is rapidly stirred at a speed of 1.5L / min. Join in the potassium carbonate solution that step (2) obtains; After reacting for 9 hours, filter, obtain ellipsoidal calcium carbonate microspheres after washing;

[0055] 2. Preparation of ellipsoidal ion-doped HA

[0056] (a). Weigh an appropriate amoun...

Embodiment 3

[0061] 1. Preparation of Ellipsoidal Calcium Carbonate Microspheres

[0062] (1). Weigh an appropriate amount of calcium nitrate, dissolve it in deionized water, and mechanically stir it for 1 second at -5°C to prepare a 0.001mol / L calcium nitrate solution;

[0063] (2). Weigh an appropriate amount of ammonium carbonate, dissolve it in deionized water, and carry out mechanical stirring for 1 second at -5°C to prepare a 0.001mol / L ammonium carbonate solution;

[0064] (3). Adjust the reaction temperature to be -5°C. Under the mechanical stirring condition that the reaction temperature is -5°C and the stirring speed is 3000rpm, the calcium nitrate solution obtained in step (1) is quickly added at a speed of 0.001L / min In the ammonium carbonate solution that step (2) obtains; After reacting for 1 week, filter, obtain ellipsoidal calcium carbonate microspheres after washing;

[0065] 2. Preparation of ellipsoidal ion-doped HA

[0066] (a). Weigh an appropriate amount of dipotass...

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Abstract

The invention relates to a method for preparing ellipsoidal ion-doped hydroxyapatite microspheres with porous surfaces. According to the method disclosed by the invention, ellipsoidal hydroxyapatite microspheres are prepared from ellipsoidal calcium carbonate microspheres as a precursor and the support of a plurality of trace ions (Mg, Sr, Zn, Ag, Fe, Si, Y, F, Cl and the like) and fluorescent ion (Eu) is achieved. No surfactant is used in the preparation process of ellipsoidal hydroxyapatite microspheres and ellipsoidal calcium carbonate microspheres, and the sizes of the obtained ellipsoidal hydroxyapatite microspheres and ellipsoidal calcium carbonate microspheres are uniform and the obtained ellipsoidal ion-doped hydroxyapatite microspheres have the characteristics of relatively high specific surface area, fluorescent tracing and bacteriostasis and other properties and are capable of adsorbing positively charged polymers. The hollow or solid ellipsoidal ion-doped hydroxyapatite microspheres prepared by the method disclosed by the invention can be applied as a drug carrier material, a bone repair material, an environmental water treatment material, food or cosmetics additives and the like.

Description

technical field [0001] The invention belongs to the field of inorganic biological materials, in particular to a method for preparing surface-porous ellipsoid-shaped ion-doped hydroxyapatite microspheres, and surface-porous ellipsoid-shaped multi-ion-doped hydroxyapatite microspheres obtained by the preparation method Application of microspheres. Background technique [0002] Hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , HA) is considered to be the chemical molecular model of the inorganic phase in natural bone, usually used in biomedical materials for bone repair, has good biocompatibility, bioinduction and bioosteoconductivity, and is widely used in gas sensing , catalysis, ion exchange and drug sustained release and other fields. The preparation of multi-ion composite HA materials by ion doping is the development trend of material development to further increase the functions and characteristics of HA microspheres. For example, Eu can achieve fluorescent tracer properties,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32
Inventor 郭燕川马铭曹霄峰
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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