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Nano-silver antibacterial composite decorated by modified chitosan, preparing method and application

A nano-silver antibacterial and composite material technology, which is applied in the fields of nanotechnology, nanotechnology, nanotechnology and other fields for materials and surface science, can solve the problems of poor stability, limited antibacterial effect, and synthesis of chitosan nanosilver composites. The process is cumbersome and other problems, and the effects of good water solubility, low price and simple preparation process are achieved.

Active Publication Date: 2014-11-05
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this nanocomposite material still has defects: on the one hand, the synthesis process of modified chitosan modified by crown ether is very cumbersome, requiring four steps of synthesis, a large amount of toxic organic solvents are introduced in each step and the intermediate product needs to be purified, costing On the other hand, due to the high molecular weight of the selected chitosan, the prepared chitosan nano-silver composite material has poor stability and is easy to agglomerate under alkaline conditions, and the antibacterial effect is limited, and it can only be used as a coating Antibacterial use of antibacterial agents on the surface of materials

Method used

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  • Nano-silver antibacterial composite decorated by modified chitosan, preparing method and application
  • Nano-silver antibacterial composite decorated by modified chitosan, preparing method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0051] (1) Preparation of modified chitosan CS-LA

[0052] Fully dissolve chitosan in water to make an aqueous solution with a chitosan concentration of 0.02 mol / L; weigh lipoic acid with 5% chitosan amino molarity, dissolve it in ethanol, and then add an equal molar amount of lipoic acid EDC and NHS were used to activate the carboxyl group of lipoic acid, mixed and added to the chitosan solution, and reacted for 4 hours at 30 °C; after the reaction was completed, the unreacted lipoic acid and EDC / NHS activator were removed by dialysis, and the reaction solution was freeze-dried to obtain improved The natural chitosan product CS-LA has the following chemical structural formula:

[0053] The modified chitosan contains disulfide bond groups, which can be used to covalently modify nano silver.

[0054] (2) Preparation of nano silver

[0055] Add 30 ml of reducing agent sodium borohydride with a concentration of 0.067 mol / L to 10 ml of a silver nitrate solution with a concent...

Embodiment 2

[0059] (1) Preparation of modified chitosan CS-LA

[0060] Fully dissolve chitosan in water to make an aqueous solution with a chitosan concentration of 0.02 mol / L; weigh lipoic acid with 50% chitosan amino molarity, dissolve it in ethanol, and then add an equal molar amount of lipoic acid EDC and NHS were used to activate the carboxyl group of lipoic acid, mixed and added to the chitosan solution, and reacted for 24 hours at 80 °C; after the reaction was completed, the unreacted lipoic acid and EDC / NHS activator were removed by dialysis, and the reaction solution was freeze-dried to obtain the same The same modified chitosan product CS-LA of step (1) in embodiment 1;

[0061] (2) The modified chitosan CS-LA is dissolved in the aqueous solution, and the silver nitrate solution is added dropwise to the above solution. The amino groups and hydroxyl groups on the polysaccharide stabilize and disperse silver nitrate, then add sodium borohydride, a reducing agent with an equal mol...

Embodiment 3

[0064] (1) Preparation of gallic acid modified chitosan CS-GA

[0065] Fully dissolve chitosan in water to make an aqueous solution with a chitosan concentration of 0.02 mol / L; weigh gallic acid with 25% chitosan amino molar number, dissolve it in ethanol, and add an equimolar amount of gallic acid EDC and NHS were used to activate the carboxyl group of gallic acid, mixed and added to the chitosan solution, and reacted at 50 °C for 24 h; after the reaction was completed, the unreacted gallic acid and EDC / NHS activator were removed by dialysis, and the reaction solution was freeze-dried to obtain The modified chitosan product CS-GA has the following chemical structural formula:

[0066]

[0067] (2) Preparation of nano silver

[0068] Add 30 ml of reducing agent sodium thiosulfate with a concentration of 0.067 mol / L to 10 ml of silver nitrate solution with a concentration of 0.1 mol / L, and use 1 mmol of sodium citrate as a stabilizer, in dark conditions and a stirring sp...

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Abstract

The invention discloses a nano-silver antibacterial composite modified by modified chitosan and a preparing method of the nano-silver antibacterial composite. According to the nano-silver antibacterial composite and the preparing method of the nano-silver antibacterial composite, the chitosan with the small molecule quantiy and good water solubility is selected and used as a raw material, chemical modification is conducted on the chitosan by using small molecules which are capable of having chelation with nano-silver particles, the modified chitosan is arranged on the surfaces of the nano-silver particles in a covalent modification mode, and the novel nano-silver antibacterial composite is prepared. The prepared nano-silver antibacterial composite modified by the modified chitosan has good water solubility and dispersibility and can be stably dispersed in a water solution in a long term without aggregation under the conditions of high salinity and wide pH. The prepared nano-silver antibacterial composite modified by the modified chitosan enables the antibacterial property of the chitosan and the antibacterial property of nano-silver to be in effective synergy, the antibacterial performance is good, and the nano-silver antibacterial composite can serve as a water coating agent to perform the surface antibacterial function on the surfaces of materials and can also permeate into fiber type materials to perform the deep internal antibacterial function.

Description

technical field [0001] The invention belongs to the technical field of nano-antibacterial composite material preparation, and in particular relates to a modified chitosan-modified nano-silver antibacterial composite material and a preparation method thereof. Background technique [0002] Polymer-based inorganic nanocomposite material is a new material formed by compounding inorganic nanomaterials and polymer matrix. This material combines the functions of polymers and inorganic nanomaterials, showing the common characteristics of inorganic nanomaterials and polymers. It has broad application prospects in many important technical fields. In the antibacterial field, nano-silver is widely used because of its strong antibacterial and broad-spectrum antibacterial effects. Its antibacterial mechanism is: nano silver destroys the permeability of the cell membrane by combining the released silver ions with the phosphide and sulfide on the bacterial cell membrane, and can continue t...

Claims

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Application Information

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IPC IPC(8): B22F1/02B22F9/24B82Y40/00B82Y30/00
Inventor 刘公岩
Owner SICHUAN UNIV
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