Preparation method of chitosan microsphere

Abstract

The invention relates to a preparation method of a chitosan microsphere. The preparation method of the chitosan microsphere comprises the following concrete steps: causing an oil phase to flow at a certain flow rate in an oil phase pipeline; vertically injecting a chitosan aqueous phase into the oil phase pipeline from an aqueous phase pipeline at a low speed; separating the chitosan aqueous phase into liquid drops with uniform size by virtue of a shearing force of an oil phase fluid, wherein the liquid drops flow into a container filled with crosslinking agent emulsion along with an oil phase; crosslinking and solidifying to obtain microspheres while stirring; and separating and drying, so that the chitosan microsphere is obtained. The chitosan microsphere prepared by adopting the preparation method has the characteristics of small particle size and high uniformity, safety and effectiveness of embolism in an interventional therapy can be improved, clinical operability can be enhanced, the clinical safety accident rate can be reduced, excessive screening is not needed to be carried out on the chitosan microsphere product to remove microspheres which are not in target particle size, the production cost is reduced, and the production efficiency is improved.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a preparation method of chitosan microspheres. Background technique [0002] With the rapid development of modern medicine, in addition to conventional drug therapy and surgical treatment, a new treatment method, that is, interventional therapy is becoming more and more mature. The key to interventional therapy is to use microspheres of appropriate particle size to embolize blood vessels in the lesion, cut off the blood supply to the diseased tissue, and achieve the purpose of inhibiting the development of the disease. effect. [0003] Chitosan, a natural polysaccharide, has been widely used in the research of microsphere preparation. The purpose of using microspheres in interventional therapy is to embolize the blood vessels of the lesion. Therefore, the uniformity of the particle size of the microspheres is highly required, and the general deviation should...

AI Technical Summary

Problems solved by technology

However, the problem that currently plagues those in the field of medical technology is that the particle size of microspheres produced by traditional microsphere preparation processes such as emulsification-crosslinking method and emulsification-solvent evaporation method is not uniform, especially for small particle size microspheres. The particle size of microspheres required for interventional embolization therapy is generally 50-500 μm, which belongs to small particle size microspheres. Within this particle size range, the particle size difference will further increase under the same process, and the deviation is often more than 50%. In order to control the particle size deviation within 20%, the finished product needs to be screened by particle size, resulting in a lot of waste of materials. Therefore, the microspheres prepared by ordinary technology are used for interventional therapy with poor curative effect, easy to cause ectopic embolism, high fatality rate, and poor safety. , in order to make up for the defect of uneven particle size, precision screening is required, which is not only time-consuming and laborious, but also causes material loss and high cost

[0004] Therefore, there is a lack of a preparation method of chitosan microspheres in the prior art, which can meet the small particle size and high uniformity requirements of interventional therapy embolization technology for microspheres, improve the safety and effectiveness of interventional therapy, and reduce the production cost. cost

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