Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of preparation method of inorganic-organic composite airgel drug carrier

A composite airgel and composite technology, applied in the field of polymers, can solve the problems of low drug loading, poor biocompatibility, and low strength, and achieve the effects of uniform pore structure, concentrated pore size distribution, and uniform particle size distribution

Inactive Publication Date: 2017-04-26
XI AN JIAOTONG UNIV
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the present invention is to provide a kind of preparation method of inorganic-organic composite airgel drug carrier, solves the problem of SiO 2 Airgel as a drug carrier material has low strength, high brittleness, poor biocompatibility, and low drug loading

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of preparation method of inorganic-organic composite airgel drug carrier

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0018] The preparation method of the inorganic-organic composite airgel drug carrier of the present invention is mainly obtained through the following steps: adding β-cyclodextrin hydrosol and SiO in proportion to the reactor 2 Alcohol sol, then add drying control chemical additives, disperse after stirring, age with ethanol aqueous solution at constant temperature, soak in ethanol solution of silane coupling agent (HMDS and ethanol solution, replace with n-hexane, and place the obtained gel at room temperature Under vacuum drying, obtain inorganic-organic composite airgel drug carrier.Concretely comprise the following steps:

[0019] 1) Preparation of β-cyclodextrin hydrosol:

[0020] In terms of mass percentage, 9.2-9.7% of β-cyclodextrin, 0.58-1.63% of epichlorohydrin, 80.69-82.3% of purified water, 7.87-7.91% of sodium hydroxide and 0.05-0.07% of A composite initiator composed of benzoyl peroxide and dimethyl azobisisobutyrate; then dissolve β-cyclodextrin in purified wat...

Embodiment 1

[0027] 1) Preparation of β-cyclodextrin hydrosol:

[0028] In terms of mass percentage, 9.4% of β-cyclodextrin, 1.63% of epichlorohydrin, 81.05% of purified water, 7.87% of sodium hydroxide and 0.05% of benzoyl peroxide and azobisiso A composite initiator composed of dimethyl butyrate; then dissolve β-cyclodextrin in purified water, adjust the pH value with sodium hydroxide, stir in a constant temperature water bath at 80°C for 30 minutes, then add epichlorohydrin and composite initiator, React in a constant temperature water bath at 60°C for 1 hour to obtain β-cyclodextrin hydrosol; wherein, benzoyl peroxide in the compound initiator accounts for 25% of the mass of the compound initiator, and dimethyl azobisisobutyrate accounts for 25% of the mass of the compound initiator. 75% of the mass of the agent;

[0029] 2)SiO2 2 Preparation of Alcohol Sol:

[0030] In terms of mass percentage, weigh 15.45% SiO 2 Alkaline silica sol with a mass content of 27%, 0.07% hydrochloric a...

Embodiment 2

[0033] 1) Preparation of β-cyclodextrin hydrosol:

[0034] In terms of mass percentage, 9.6% of β-cyclodextrin, 1.6% of epichlorohydrin, 80.85% of purified water, 7.89% of sodium hydroxide and 0.06% of benzoyl peroxide and azobisiso A compound initiator composed of dimethyl butyrate; then dissolve β-cyclodextrin in purified water, adjust the pH value with sodium hydroxide, stir in a constant temperature water bath at 81°C for 35 minutes, then add epichlorohydrin and compound initiator, React in a constant temperature water bath at 61°C for 1.25h to obtain β-cyclodextrin hydrosol; wherein, benzoyl peroxide in the compound initiator accounts for 30% of the mass of the compound initiator, and dimethyl azobisisobutyrate accounts for 30% of the mass of the compound initiator. 70% of the initiator mass;

[0035] 2)SiO2 2 Preparation of Alcohol Sol:

[0036] In terms of mass percentage, weigh 16.32% SiO 2 Alkaline silica sol with a mass content of 32%, 0.09% hydrochloric acid wit...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of an inorganic-organic compound aerogel drug carrier. The preparation method comprises the following steps: in mass percent, adding 8.1-9.1% of beta-cyclodextrin hydrosol, 90.4-91.5% of SiO2 alcosol and 0.2-0.5% of drying control chemical additive into a reactor to stir and disperse uniformly to obtain a gel compound; aging the gel compound by a mixed solution of absolute ethyl alcohol and water at a constant temperature to obtain an aged product; soaking the aged product in an ethanol solution of a silane coupling agent, replacing by a replacing solvent after the soaking, and carrying out vacuum drying at the room temperature to obtain the inorganic-organic compound aerogel drug carrier. The inorganic-organic compound aerogel drug carrier synthesized by the method can be applied to the entrapment and release of anti-inflammation and analgesia drugs, has better drug release performance under the synergistic effect of the beta-cyclodextrin and silicon dioxide, and provides a new thought for the design and research of novel drug carriers.

Description

technical field [0001] The invention belongs to the technical field of polymers, and in particular relates to a preparation method of an inorganic-organic composite airgel drug carrier. Background technique [0002] With its good biocompatibility, high porosity, large specific surface area and good stability, aerogel has an open internal pore structure, high porosity, large specific surface area and The non-physiological toxicity makes silica airgel an excellent carrier for drugs, and has broad application prospects in drug carriers. Due to the expensive preparation cost of airgel, the insurmountable low strength and high brittleness of the material itself have become bottlenecks restricting its wide application. Contents of the invention [0003] The object of the present invention is to provide a kind of preparation method of inorganic-organic composite airgel drug carrier, solves the problem of SiO 2 As a drug carrier material, airgel has the problems of low strength,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/38A61K47/04A61K31/192
Inventor 秦蓓张光伟陈卓梁飞
Owner XI AN JIAOTONG UNIV