Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of amphiphilic copolymer network and preparation method thereof

An amphiphilic copolymer and copolymer technology, applied in the field of medical polymer materials, can solve the problems of uncontrollable network structure size, poor mechanical properties of network structure, poor controllability of molecular weight, etc., and achieve easy molecular design and good swelling performance , Good cross-linking effect

Active Publication Date: 2017-03-22
DONGHUA UNIV
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The relative molecular weight distribution of products obtained by this kind of polymerization method is wide, the controllability of molecular weight is poor, and the difficulty of synthesis increases with the increase of molecular weight, resulting in poor mechanical properties of the prepared network structure and uncontrollable size of the network structure

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of amphiphilic copolymer network and preparation method thereof
  • A kind of amphiphilic copolymer network and preparation method thereof
  • A kind of amphiphilic copolymer network and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0044] In the method for preparing the amphiphilic copolymer network of the present invention, preferably the triethanolamine in the first step is refined triethanolamine.

[0045] Preferably, the acid-binding agent described in the first step is triethylamine, sodium hydroxide, potassium hydroxide or pyridine.

[0046] Preferably, the nucleophilic substitution reagent described in the first step is bromoacyl bromide or chloroacyl chloride.

[0047] Preferably, the hydrophilic monomer described in the second step is an acrylamide monomer, an acrylamide monomer, an acrylate monomer or a methacrylate monomer.

[0048] Preferably, the ligand A described in the second step is 2'2-bipyridine (Bpy), tris-(N,N-dimethylaminoethyl)amine (Me 6 TREN), pentamethyldiethylenetriamine (PDMAETA), and 4-dimethylaminopyridine (DMAP) or a mixture of two or more.

[0049] Preferably, the first catalyst described in the second step is cuprous chloride, cuprous bromide or ferrous chloride.

[00...

Embodiment 1

[0078] (1) Triethanolamine is distilled under reduced pressure to obtain refined triethanolamine, 10 parts of refined triethanolamine are dissolved in 600 parts of tetrahydrofuran THF to obtain triethanolamine solution, 80 parts of triethylamine are added, and 30 parts of 2-bromoisobutyl are added dropwise Acyl bromide was reacted in an ice-water bath for 3 hours. After removing the ice-water bath, it was reacted at room temperature for 6 hours. The product was filtered to remove the white precipitate, and the solvent was removed, then dissolved in n-hexane, washed with deionized water, and dried for 24 hours to obtain the terminal band Br's star ATRP small molecule initiator.

[0079] (2) 0.8 parts of 2'2-bipyridine, 0.48 parts of star ATRP small molecule initiator, 16 parts of hydroxyethyl methacrylate (HEMA), 0.0768 parts of cuprous chloride, 14 parts of n-propanol, butanone 6 parts were mixed, after deoxygenation at -20°C, reacted at 5°C for 24 hours, passed the mixture th...

Embodiment 2

[0091] (1) Triethanolamine is distilled under reduced pressure to obtain refined triethanolamine, 10 parts of refined triethanolamine are dissolved in 800 parts of dichloromethane to obtain triethanolamine solution, 70 parts of sodium hydroxide are added, and 70 parts of 2-bromo Isobutyryl bromide was reacted in an ice-water bath for 3 hours. After removing the ice-water bath, it was reacted at room temperature for 6 hours. The product was filtered to remove the white precipitate, and the solvent was removed, then dissolved in n-hexane, washed with deionized water, and dried for 24 hours to obtain Star-shaped ATRP small molecule initiator with Br at the end.

[0092] (2) 0.8 parts of 2'2-bipyridine, 0.64 parts of star ATRP small molecule initiator, 20 parts of dimethylaminoethyl methacrylate (DMAEA), 0.2 parts of cuprous chloride, 21 parts of n-propanol, Mix 9 parts of butanone, remove oxygen at -20°C, react at 50°C for 24 hours, pass the mixture through a neutral alumina chro...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
tensile strengthaaaaaaaaaa
sizeaaaaaaaaaa
tensile strengthaaaaaaaaaa
Login to View More

Abstract

The invention discloses an amphiphilic copolymer network, which is composed of a star amphiphilic copolymer and a hydrosilation crosslinking agent by crosslinking, wherein the star amphiphilic copolymer is prepared by carrying out chemical reaction on a star amphiphilic homopolymer and a suspension alkynyl containing hydrophobic segmented copolymer; and the swelling degree of the amphiphilic copolymer network in n-hexane is 20-150%, the swelling degree of the amphiphilic copolymer network in water is 50-800%, the swelling degree of the amphiphilic copolymer network in ethanol is 400-1000%, and the oxygen transmittance is 500-1600 Barrers. The amphiphilic copolymer network can be used as a medical polymer material. The invention also discloses a preparation method of the amphiphilic copolymer network.

Description

technical field [0001] The invention belongs to the field of medical polymer materials, and in particular relates to a novel amphiphilic copolymer network, its preparation method and its application in the medical field. [0002] technical background [0003] Amphiphilic copolymer network is a polymer material with broad application prospects. For its synthesis method, most of the current literature reports are based on free radical polymerization and group transfer polymerization (GTP) method to synthesize the amphiphilic copolymer network, such as the literature "Amphiphilic Conetworks and Gels Physically Cross-Linked via Stereocomplexation of Polylactide" (Fan , Xiaoshan; Wang, Mian; Yuan, Du; He, Chaobin.Langmuir (2013), 29 (46), 14307-14313.) used free radical polymerization to prepare poly D-lactide / L-lactide / Crosslinked network of acrylates and ethylene glycol / methyl ether acetate; literature "Amphiphilic Co-networkswithMoisture-Induced Surface Segregation for High-P...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/24C08L87/00C08G81/02C08F293/00C08F120/28
Inventor 何春菊王海晔刘大朋轩慧霞张东瑞
Owner DONGHUA UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com