Pharmaceutical composition for treating anaphylactoid purpura and preparation method of pharmaceutical composition

A technology for allergic purpura and a composition, which is applied in the field of traditional Chinese medicine and can solve the problems of easy recurrence and the like

Active Publication Date: 2015-06-03
北京古楼疑难病医学研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lesions are symmetrically distributed

Method used

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  • Pharmaceutical composition for treating anaphylactoid purpura and preparation method of pharmaceutical composition
  • Pharmaceutical composition for treating anaphylactoid purpura and preparation method of pharmaceutical composition
  • Pharmaceutical composition for treating anaphylactoid purpura and preparation method of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The preparation of embodiment 1 Chinese medicine extract

[0019] (1) Ingredients: Desmodium 250g, Plantago 250g, Haijinsha 140g, Corn silk 140g, Hedyotis diffusa 140g, Houttuynia cordata 140g, Imperata 140g, bell bean 140g, Salvia 140g, safflower 100g, peach kernel 100g, Eupatorium 100g, Qumai 100g, Motherwort 100g, Spatholobus 100g, Chinese rose 140g, pearl ginseng 140g, paeonol 140g, scrophulariaceae 140g, red peony 140g, comfrey 140g, Baiwei 140g, rehmannia 140g, ink Eclipta 140g, Anemarrhena 140g, Scutellaria baicalensis 100g, Forsythia 100g, Quanshen 100g;

[0020] (2) Take paeonol root, salvia miltiorrhiza, rehmannia root of prescription quantity, mix, pulverize, add volume concentration and be 70% ethanol solution diafiltration, the volume of ethanol solution is 12 times of medical material quality, leachate decompression is recovered to no alcohol Taste, concentrate, get percolation concentrate and medicinal residues for later use;

[0021] (3) Mix the dregs ...

Embodiment 2

[0023] The preparation of embodiment 2 Chinese medicine granules, capsules

[0024] prescription:

[0025]

[0026]Preparation process: pass mannitol, sucrose, sodium carboxymethyl starch, microcrystalline cellulose, and sodium lauryl sulfate through a 100-mesh sieve, and set aside; weigh the dry powder of the Chinese medicine extract prepared in Example 1, and mannitol, sucrose , microcrystalline cellulose, sodium carboxymethyl starch, sodium lauryl sulfate, mix well, add 5% starch slurry to make soft material, pass through 20 mesh sieve to make wet granules, dry at 50-60°C for 2 hours, pass through 16 mesh Sieve the granules, add talcum powder, and mix well; divide into 20g / bag to obtain granules, or fill capsule shells to obtain capsules.

Embodiment 3

[0027] The preparation of embodiment 3 Chinese medicine tablet

[0028] prescription:

[0029]

[0030] Preparation process: pass mannitol, sucrose, sodium carboxymethyl starch, microcrystalline cellulose, and sodium lauryl sulfate through a 100-mesh sieve, and set aside; weigh the dry powder of the Chinese medicine extract prepared in Example 1, and mannitol, sucrose , microcrystalline cellulose, 2 / 3 amount of sodium carboxymethyl starch, 1 / 2 amount of sodium lauryl sulfate, mix well, add 5% starch slurry to make soft material, pass through a 20-mesh sieve to make wet granules, 50 Dry at ~60°C for 2 hours, pass through a 16-mesh sieve for granulation, add the remaining 1 / 3 amount of sodium carboxymethyl starch and 1 / 2 amount of sodium lauryl sulfate, mix well, press 1000 tablets, each tablet contains Chinese herbal extract 50mg.

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating anaphylactoid purpura and a preparation method of the pharmaceutical composition. The pharmaceutical composition comprises an active component and a pharmaceutically acceptable auxiliary material, wherein the active component is prepared from lysimachia christinae hance, semen plantaginis, lygodium japonicum, corn stigma, oldenlandia diffusa, houttuynia cordata, lalang grass rhizome, crotalaria albida, salviae miltiorrhizae, flos carthami, peach kernel, lycopus lucidus, dianthus superbus, herba leonuri, caulis spatholobi, China rose, rhizoma panacis majoris, cortex moutan, radix scrophulariae, red peony root, radices lithospermi, cynanchum atratum, dried rehmannia root, eclipta, rhizoma anemarrhenae, scutellaria baicalensis, fructus forsythia and polygonum bistorta. The pharmaceutical composition is capable of lowering the quantity of urinary albumin of a patient and the content of serum circulating immune complex, so that the target of curing anaphylactoid purpura is reached.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition for treating allergic purpura and a preparation method thereof. Background technique [0002] Henoch-Schonlein purpura is a systemic vasculitis mediated by immune complexes that can lead to increased fragility of vessel walls, mainly an allergic disease mediated by immunoglobulin A (IgA). The disease is prone to occur in children and adolescents. At the beginning, there may be fever, headache, arthralgia, and general malaise. Skin lesions manifest as pinhead to soybean-sized petechiae, ecchymosis, or urticaria-like rash. In severe cases, blisters, blood blisters, and even ulcers may occur. It tends to occur on the extensor side of the limbs, especially the lower limbs and buttocks. The lesions are symmetrically distributed, appear in batches, and are prone to recurrence. Those with only skin damage are called simple...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P37/08A61P9/14
Inventor 孙号
Owner 北京古楼疑难病医学研究院有限公司
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