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Method for preparing medical antisepsis and anti-inflammation sponge

An antibacterial and anti-inflammatory, sponge technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of insignificant hemostatic effect, poor tissue adhesion, and dependence on hemostatic function, and achieve shortening of coagulation time and fibrin formation time, hemostasis Fast, fast-adhesive effect

Inactive Publication Date: 2015-09-16
SUZHOU BEC BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hemostatic materials reported at present mainly include powders (zeolite, collagen powder and potato starch), porous sponges (gelatin sponge, collagen sponge), oxidized regenerated cellulose and fibrin glue, etc., and they have certain weak points respectively: gelatin and Collagen has poor tissue adhesion, and the hemostatic function of both depends on sufficient platelets and coagulation factors, so the application is limited; fibrin glue is derived from blood, which may cause viral infection; porous zeolite and potato starch absorb The water in the blood will release a lot of heat, causing wound inflammation
Currently, pure chitosan hemostatic materials have the problems of poor toughness and insignificant hemostatic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A preparation method of antibacterial and anti-inflammatory medical sponge. The preparation method includes the following steps:

[0016] (1) Weigh the components in parts by weight: 4 parts of triglyceride monostearate, 6 parts of lemon peel pectin, 7 parts of sodium alginate, 5 parts of fibroin, 5 parts of metronidazole, 13 parts of starch, 15 parts of polyvinylpyrrolidone, 6 parts of xanthan gum, 7 parts of linoleic acid, 5 parts of antibacterial agent, 13 parts of porogen and 70 parts of deionized water;

[0017] (2) Put the above weighed components in a stirrer for stirring, the stirring speed is 50-100rpm, and the stirring time is 30min;

[0018] (3) Pour the mixture obtained in step (2) into the film forming device, and place it in a vacuum freeze dryer for 15h~35h to freeze-dry to obtain an antibacterial and anti-inflammatory medical sponge.

[0019] The antibacterial agent is nano silver inorganic antibacterial agent, nano zinc oxide or ammonium dihydrogen phosphate. ...

Embodiment 2

[0024] A preparation method of antibacterial and anti-inflammatory medical sponge. The preparation method includes the following steps:

[0025] (1) Weigh the components in parts by weight: 5 parts of triglyceride monostearate, 10 parts of lemon peel pectin, 12 parts of sodium alginate, 8 parts of fibroin, 8 parts of metronidazole, 20 parts of starch, 19 parts of polyvinylpyrrolidone, 7 parts of xanthan gum, 9 parts of linoleic acid, 6 parts of antibacterial agent, 15 parts of porogen and 100 parts of deionized water;

[0026] (2) Put the weighed components in a stirrer for stirring, the stirring speed is 50-100rpm, and the stirring time is 30min;

[0027] (3) Pour the mixture obtained in step (2) into the film forming device, and place it in a vacuum freeze dryer for freeze drying for 15h~35h to obtain an antibacterial and anti-inflammatory medical sponge.

[0028] The antibacterial agent is nano silver inorganic antibacterial agent, nano zinc oxide or ammonium dihydrogen phosphate....

Embodiment 3

[0033] A preparation method of antibacterial and anti-inflammatory medical sponge. The preparation method includes the following steps:

[0034] (1) Weigh the components in parts by weight: 3 parts of triglyceride monostearate, 3 parts of lemon peel pectin, 3 parts of sodium alginate, 3 parts of fibroin, 3 parts of metronidazole, 5 parts of starch, 12 parts of polyvinylpyrrolidone, 4 parts of xanthan gum, 5 parts of linoleic acid, 3 parts of antibacterial agent, 10 parts of porogen and 50 parts of deionized water;

[0035] (2) Put the above weighed components in a stirrer for stirring, the stirring speed is 50-100rpm, and the stirring time is 30min;

[0036] (3) Pour the mixture obtained in step (2) into the film forming device, and place it in a vacuum freeze dryer for freeze drying for 15h~35h to obtain an antibacterial and anti-inflammatory medical sponge.

[0037] The antibacterial agent is nano silver inorganic antibacterial agent, nano zinc oxide or ammonium dihydrogen phosphat...

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PUM

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Abstract

The invention discloses a method for preparing medical antisepsis and anti-inflammation sponge. The preparing method comprises the following steps that components are weighed according to the weight part proportion, the weighed components are arranged into a stirrer to be stirred, the stirring rotating speed is 50-100 rpm, and the stirring time is 30 min; the obtained mixed solution is poured into a film forming device, the film forming device is arranged in a vacuum freezing drying machine for freeze drying for 15 h to 35 h, and then the medical antisepsis and anti-inflammation sponge is obtained. The raw materials of the preparing technology are wide in source and low in cost. The prepared medical sponge is free of immunogenicity, the bonding speed to the wound surface is high, bonding firmness is high, the physical hemostatic effect is obvious, the performance of the medical sponge is flexible, the medical sponge can be used without preprocessing, and the cost performance is extremely high.

Description

technical field [0001] The invention belongs to the field of new medical materials and relates to a sponge material and a preparation method thereof, in particular to a medical hemostatic sponge material which is loose and porous and has a high liquid-absorbing expansion rate and a preparation method thereof. technical background [0002] The rapid development of modern surgical medical technology has made great contributions to saving lives and healing the wounded. There are three major obstacles to the development of surgical operations, namely pain, wound infection, and bleeding. The problem of pain has been basically solved, and the continuous replacement of antibiotics has also basically solved the problem of wound infection. Bleeding has just become the biggest obstacle hindering the development of surgical operations. In emergency treatment of sudden accidents and trauma hemostasis in the operation process, it is very important for patients to effectively stop bleed...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/44A61L15/46
Inventor 李苏杨李文遐徐勤霞
Owner SUZHOU BEC BIOLOGICAL TECH
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