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Medicine composition for treating pediatric enteritis and preparing method thereof

A technology of children's enteritis and composition, which is applied in the field of pharmaceutical preparations, can solve the problems of antibiotic resistance, food is easy to vomit, and is not a treatment method, and achieves the effect of protecting gastrointestinal mucosa, no toxic side effects, and short treatment period

Inactive Publication Date: 2015-11-11
王一鸣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] After children suffer from enteritis, their body resistance is poor, their spleen and stomach are weak, and the food they eat is easy to vomit out. Therefore, it is not suitable to take a large amount of drugs with strong medicinal properties for treatment. The existing enema method is too irritating to children, and antibiotics will produce resistance. The nature of the medicine is not a good treatment method, so there is an urgent need for a medicine that is mild in nature, can protect the intestinal mucosa, invigorate the spleen and regulate the stomach, supplement nutrients, and enhance the resistance of children

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0062] When the dosage form of the pharmaceutical composition is a granule, its preparation method comprises the following steps:

[0063] The first step is to mix the raw materials of the pharmaceutical composition according to the stated ratio, add ethanol with an alcohol concentration of 85% to 95% that is 4 to 8 times that of the mixture, heat to boiling and reflux for 3 to 5 hours, and filter. Use the percolation method to percolate slowly at a rate of 1-2ml per minute, collect the percolation liquid, and then concentrate under reduced pressure at a vacuum of 0.06-0.09Mpa to a paste with a relative density of 1.04-1.10 at 50-60°C. Spray drying, the air inlet temperature of the spray dryer is 160-175°C, the outlet air temperature is 80-85°C, and then crushed into powder to make dry paste powder;

[0064] In the second step, 0.2-0.4 times of sucrose powder and 0.1-0.2 times of dextrin are added to the obtained dry paste powder to form granules, and dried at 40-50° C. to obt...

Embodiment 1

[0074] Embodiment 1 Granules

[0075] The preparation process of the granules of the present invention is as follows: take Laojunxu 140g, eucalyptus leaves 280g, Saikui 160g, Liedang 200g, Shijianchuan 170g, Dingjingcao 300g, Amomum 240g, Polygonum water 160g, Smilax 320g, malt 140g, 240g amaranth, 180g piercing stone, 300g licorice, 220g phoenix grass, 300g oak bark, 150g halogen alkali, 330g andrographis paniculata, 400g mint, 140g delphinium, 250g stomach cold grass, 150g Chinese yam, 320g yam , Dingguicao 160g, thorn rose fruit 300g, barley tiller 200g, coix seed 320g, houttuynia cordata 160g and tuola aster 240g;

[0076] The first step is to mix the raw materials of the pharmaceutical composition according to the stated ratio, add ethanol with an alcohol concentration of 90% that is 7 times that of the mixture, heat to boiling and reflux for 4 hours, filter, and use the percolation method at a rate of 90% per minute. Slowly percolate at a speed of 1.5ml, collect the per...

Embodiment 2

[0078] Embodiment 2 capsules

[0079] The production process of the capsule of the present invention is as follows: take Laojunxu 160g, eucalyptus leaves 240g, Saikui 150g, Liedang 300g, Shijianchuan 220g, Dingjingcao 130g, Amomum 180g, Polygonum water 140g, Smilax 320g, malt 200g, amaranth 300g, piercing stone 160g, licorice 240g, phoenix grass 150g, oak bark 320g, halogen alkali 150g, andrographis 240g, mint 350g, delphinium 220g, stomach cold grass 180g, scorpion 220g, yam 330g , Dingguicao 200g, thorn rose fruit 300g, barley tiller 210g, coix seed 340g, houttuynia cordata 200g and tuola aster 160g;

[0080] The first step is to mix the raw materials of the pharmaceutical composition in proportion, add ethanol with an alcohol concentration of 95% that is 3 times the mass of the mixture, heat and reflux for 2 hours, extract, and filter to obtain the first extract; Add 90% ethanol with an alcohol concentration of 1.5 times the mass of the dregs to the dregs, heat and reflux ...

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PUM

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Abstract

The invention discloses a medicine composition for treating pediatric enteritis and a preparing method thereof. The medicine composition comprises cynanchum mooreanum, folium eucalypti, coromandel coast falsemallow, orobanche coerulescens, Salvia chinensis, vandellia cordifolia, fructus amomi, polygonum hydropiper, chinaroot greenbrier, malt, acalypha australis, cudrania cochinchinensis, liquorice, phoenix-tail fern, mongolian oak bark, alkali halide, herba andrographitis, mint, delphinium candelabrum, roots of peucedanum praeruptorum dunn, pennycress, Chinese yams, zornia gibbosa, rosa davurica, malt, semen coicis, cordate houttuynia and turbinate aster. The medicine composition has the advantages of tonifying the spleen, regulating the stomach, aiding digestion, clearing heat, promoting diuresis, protecting the intestine and stomach mucosas, enhancing resistance and relieving wind chill and the advantages of being quick in effect taking, high in effective rate, definite in curative effect, short in treatment course, free of toxic and side effect, low in price and the like.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition for treating infantile enteritis and a preparation method thereof. Background technique [0002] Enteritis in children is mostly caused by infection with bacteria or viruses, such as rotavirus, adenovirus, Coxsackie virus, etc. However, the symptoms of viral enteritis are generally mild. The symptoms of enteritis caused by bacteria are severe. Among them, common bacteria include Campylobacter jejuni, Salmonella, Shigella, pathogenic Escherichia coli, Staphylococcus aureus, etc.; It is an increase in the number of stools. Moderate enteritis in children is manifested by more than 10 stools per day, which are egg-custard-like or watery, with dehydration, indigestion, and bloating. Severe enteritis in children is manifested by spurting stools, severe dehydration, skin Dryness, breathing discomfort, collapse, lack of nutrients, and e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61P1/00A61P37/04
Inventor 王一鸣王玉洁
Owner 王一鸣