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Double-layer polyurethane-based collagen-compounded dressing

A technology of polyurethane and polyurethane film, applied in medical science, absorbent pads, bandages, etc., can solve the problems of unfavorable wound skin tissue regeneration, complex manufacturing process, poor biocompatibility, etc., achieve good application prospects, wide source of materials, production high efficiency effect

Inactive Publication Date: 2015-11-18
杭州承前医数科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these materials have more or less disadvantages: for example, natural materials, although they have good biocompatibility, are often complex in production process, expensive, low in mechanical strength, and difficult to operate; while synthetic materials are often biocompatible. Poor stability, not conducive to the regeneration of wound skin tissue, and not easy to biodegrade

Method used

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  • Double-layer polyurethane-based collagen-compounded dressing
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  • Double-layer polyurethane-based collagen-compounded dressing

Examples

Experimental program
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Effect test

Embodiment 1

[0034] A preparation method for a polyurethane-based double-layer dressing of composite collagen, comprising the steps of:

[0035] 1) Preparation of polyurethane prepolymer: Add 128g of random polymer of ethylene oxide and propylene oxide (average molecular weight 3kD, ethylene oxide content 90%) and 25g of toluene diisocyanate into a round bottom flask , mechanically stirred and mixed evenly, heated to 60° C., and reacted for 8 hours to generate a polyurethane prepolymer with isocyanate end groups. In an intermediate stage of the reaction, the product is sampled and the content of isocyanate groups is determined according to the titration method using n-butylamine standard solution.

[0036] 2) Preparation of collagen composite hydrophilic polyurethane foam dressing: mix 50wt% polyurethane prepolymer, 34wt% distilled water as foaming agent, 15wt% glycerol as cross-linking agent and 1wt% type I collagen ( Dissolved in 0.05mol / L acetic acid solution to prepare a collagen solu...

Embodiment 2

[0039] Step 1) Preparation of polyurethane prepolymer: The isocyanate used is diphenylmethane diisocyanate, xylene diisocyanate or hexamethylene diisocyanate, and the others are the same as in Example 1.

Embodiment 3

[0042] Step 1) Preparation of polyurethane prepolymer: a random polymer of ethylene oxide and propylene oxide (the average molecular weight is 3kD, and the content of ethylene oxide is 50%), and the others are the same as in Example 1.

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Abstract

The invention discloses double-layer polyurethane-based collagen-compounded dressing. The dressing comprises an inner layer and an outer layer, wherein the inner layer adopts collagen-compounded hydrophilic polyurethane foam dressing, the outer layer adopts a transparent polyurethane film, and the inner layer and the outer layer are bonded through a medical pressure sensitive adhesive. The double-layer polyurethane-based collagen-compounded dressing has the advantages of appropriate breathability, moisture permeability and water absorption, excellent antibacterial performance, capability of promoting wound repair and reducing scar forming and the like. Besides, the required replacement frequency of the dressing is less, pain of wound can be relieved during replacement, and the dressing is easily accepted by a patient.

Description

technical field [0001] The invention relates to a dressing, in particular to a polyurethane-based double-layer dressing composed of collagen. Background technique [0002] Skin defect is a very common surgical disease, such as wounds in various accidents and wars and self-diseases such as skin ulcers caused by diabetes. Skin defects can affect the patient's appearance in mild cases, and in severe cases can cause infection or a large loss of electrolytes and water, leading to the death of the patient. In particular, in the case of bedsores or surgical wounds, a large amount of secretions seeps out from the injured part of the skin, and thus it is necessary to prevent the secretions from stagnating on the wound to suppress infection of the skin. However, in order to effectively heal injured skin, moisturization is necessary, so the wound surface cannot be left in an overly dry state. [0003] Requirements for an ideal wound dressing: ①Physical properties: suitable strength, ...

Claims

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Application Information

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IPC IPC(8): A61L15/26A61L15/32C08G18/66C08G18/48C08G18/32C08G18/76C08G18/73C08L75/08C08L89/00C08J9/08C08J9/14
Inventor 毛峥伟张匀吴炜卢承志
Owner 杭州承前医数科技有限公司
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