Biomimetic multifunctional coating for magnesium-based medical materials and devices, preparation and application

A multi-functional coating and device technology, applied in coating, medical science, surgery, etc., can solve the problems of surface modification, modification effect, film defects, matrix magnesium corrosion, etc., and slow down the degradation rate in vitro. , Biocompatibility improvement, the effect of improving biocompatibility

Active Publication Date: 2019-01-25
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, for materials that are easy to corrode in aqueous solution, such as magnesium and magnesium alloys, the preparation method in the aqueous solution environment will simultaneously cause the degradation of the matrix magnesium material, and lead to obvious defects in the prepared film, which will affect the material and medical devices. Corrosion resistance performance during application, can not achieve ideal surface modification and modification effect
[0004] Application number is 201310647164.9 patent "method for bonding carboxymethyl chitosan bioactive molecules on the surface of magnesium alloy", one of which discloses the deposition of polydopamine film layer on the surface of magnesium alloy, but in this patent document, 1) polydopamine layer It is used to fill a large number of micropores of the MgO corrosion-resistant coating to improve the rough, porous and cracked defects of the prepared MgO coating; 2) The preparation method of the polydopamine layer is "regulate 2mg / The pH value of the ethanol solution of mL dopamine hydrochloride is 8.5, and the magnesium alloy is soaked in the solution. The reaction environment contains a small amount of water and chloride ions, so it may cause corrosion of the matrix magnesium during long-term immersion; 3) Further Bonding carboxymethyl chitosan to improve cell compatibility; therefore, the preparation of the polydopamine layer is mainly used to bond carboxymethyl chitosan bioactive molecules to improve the Biocompatibility
Therefore, the patent also does not really address corrosion resistance

Method used

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  • Biomimetic multifunctional coating for magnesium-based medical materials and devices, preparation and application
  • Biomimetic multifunctional coating for magnesium-based medical materials and devices, preparation and application
  • Biomimetic multifunctional coating for magnesium-based medical materials and devices, preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Add 0.2wt%-5wt% triethylamine into ethanol, stir and mix evenly. Dissolve dopamine hydrochloride in the above-mentioned ethanol solution containing triethylamine at a ratio of 1 mg / mL, and stir to fully dissolve. Immerse the pure Mg disc sample in the dopamine solution, soak at 30°C for 18 hours, take it out, wash it with isopropanol and ultrapure water in sequence, and dry it with nitrogen after ultrasonication for 1 minute. figure 1 The XPS detection in the middle shows that the surface components of magnesium after surface modification are mainly C, N and O, and the contents are consistent with the polydopamine reported in the literature, and the substrate Mg signal basically disappears (<2wt%). It was proved that a layer of dense polydopamine film was successfully prepared on the surface of pure magnesium. The results of ellipsometry showed that the thickness of the polydopamine film was about 22nm. The mechanical property test results show that the polydopamine c...

Embodiment 2

[0042] Add 0.3wt%-3wt% sodium hydroxide solid into the isopropanol solution, stir to dissolve. Dissolve dopamine hydrochloride in the above solution at a ratio of 4 mg / mL, and stir to fully dissolve. The fluorinated pretreated Mg-Nd-Zn-Zr alloy disc samples were immersed in the dopamine solution, soaked at 40°C for 24 hours, taken out, washed with ethanol and ultrapure water in sequence, ultrasonicated for 1 minute, and then blown dry with nitrogen. The sample prepared by this method has a smooth and complete surface under the SEM observation, while the sample prepared in aqueous solution for 24 hours according to US Patent 20080149566 and Chinese Patent CN102000658B method presents obvious cracks ( figure 2 ), it can be seen that the preparation in an aqueous solution environment leads to obvious degradation and corrosion of the magnesium matrix, and the obtained polydopa film layer is not dense and complete, and has crack-like defects; while the structure of the matrix and ...

Embodiment 3

[0044] Add ethylenediamine into tetrahydrofuran at a ratio of 0.1wt%-3wt%, and mix well. Dissolve dopamine hydrochloride in the above solution at a ratio of 2 mg / mL, and stir to fully dissolve. Immerse the untreated AZ31 (Mg-Al) alloy bone plate sample in dopamine solution, soak it on a shaker at 25°C for 8 hours, take it out, wash it with ethanol and ultrapure water in sequence, ultrasonicate it for 1 minute, and blow it dry with nitrogen. The results of ellipsometry showed that the thickness of the polydopamine film was about 15nm. The mechanical property test results show that the polydopamine coating has a strong binding force with the substrate, exceeding 12MPa. Using ICP-AES to detect the content of magnesium ions in the three-day extract, the degradation rate of the sample modified polydopamine film was about 64% lower than that of the AZ31 alloy sample. The cytotoxicity test results of osteoblast MC3T3 showed that the cytotoxicity of the sample modified with polydopa...

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Abstract

The invention discloses a multifunctional bionic coating for magnesium-base medical materials and devices as well as a preparation method and application of the multifunctional bionic coating. The preparation method of the coating comprises the following steps: 1) preparation of an alkaline catalyst-organic solvent: dissolving and mixing an alkaline catalyst in an organic solvent; 2) preparation of a dopamine monomer solution: dissolving and mixing a dopamine monomer in the alkaline catalyst-organic solvent; and 3) preparation of a coating: immersing a magnesium-base material or a device in the dopamine monomer solution, and promoting in-situ growth through a self-polymerization reaction so as to obtain a required polydopamine coating. The method disclosed by the invention can be used for solving the problem of coating defect due to easy corrosion of the magnesium base in the preparation of the polydopamine coating in a water solution environment; and the prepared coating has the following characteristics and functions: the coating is dense and complete and is capable of significantly improving the corrosion resistance of the magnesium base and delaying degradation, the coating is capable of significantly improving the biocompatibility of magnesium-base materials and devices, and the coating, as an intermediate layer, is capable of achieving secondary functionalization and multi-functionalization; and the coating is simple and convenient in operation process, strong in binding force with a substrate and controllable in thickness.

Description

technical field [0001] The invention relates to the technical field of medical material preparation, in particular to a bionic multifunctional coating for magnesium-based medical materials and devices, as well as its preparation and application. Background technique [0002] Magnesium-based materials have good development and application prospects in the field of biomedical materials due to their excellent mechanical properties, degradable properties, and biocompatibility. However, the rapid degradation rate of magnesium greatly limits its application, so it is necessary to carry out appropriate surface modification, so as to improve its corrosion resistance on the one hand, and further improve its biocompatibility and other functions on the other hand. characteristic. Traditional surface modification methods, such as chemical conversion coating (fluorination, phosphorylation, etc.), anodic oxidation, etc., can only play a limited short-term protective effect on the magnesi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/50A61L27/54A61L31/10A61L31/14A61L31/16C08G73/06
Inventor 裴佳史永娟元峰袁广银
Owner SHANGHAI JIAOTONG UNIV
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