Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of betaine

A technology of betaine and glycine methyl ester, applied in the chemical industry, can solve the problems of no operational significance, destroying the quality of betaine, unfavorable large-scale production, etc., and achieves the effects of easy large-scale popularization and application, high safety and simple operation.

Active Publication Date: 2015-12-09
宜兴市天石饲料有限公司
View PDF5 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Simultaneously, also can have a small amount of heavy metal substance to be mixed in the product, these impurity all have destroyed the quality of main product betaine greatly, can't satisfy some fields that have special requirement to salt content; The second method is to use choline as raw material ( WO2001040818), under the catalysis of noble metals (such as Pt), obtain betaine with oxygen oxidation, but this method uses noble metals, and the use of oxygen also requires special conditions, so the cost is higher, which is not conducive to large-scale production; The method requires the use of highly toxic chemicals (such as diazomethane, etc.), which has no operational significance in actual production

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of betaine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The chemical reaction equation involved in this embodiment is as figure 1 As shown, the specific steps are:

[0019] A. Add 89g glycine methyl ester, 1780g acetonitrile and 302.4g sodium bicarbonate in the three-necked flask that reflux condenser, thermometer, constant pressure dropping funnel and magnetic stirring device are housed, fully stir stand-by;

[0020] B. Add 363g methyl methanesulfonate dropwise under stirring, after the addition is completed, gradually rise to room temperature, heat to reflux and fully stir for 32 hours;

[0021] C. After the reaction finishes, adding concentration under stirring is 890g of 5% aqueous sodium hydroxide solution, and now the volume of the reaction solution is denoted as V, then warming up to 50°C, stirring and reacting for 20 hours, removing most of the solvent by distillation after the reaction finishes, Concentrate the volume to 28% V, filter to remove insoluble matter, and pass the filtrate through an ionic macroporous ad...

Embodiment 2

[0025] A. Add 89g glycine methyl ester, 750g acetonitrile and 252g sodium bicarbonate in the three-necked flask that reflux condenser, thermometer, constant pressure dropping funnel and magnetic stirring device are housed, fully stir stand-by;

[0026] B. Add 330 g of methyl methanesulfonate dropwise while stirring, after the addition is completed, gradually rise to room temperature, heat to reflux and fully stir for 16 hours.

[0027] C. After the reaction is over, add 890g of sodium hydroxide aqueous solution with a mass fraction of 5% under stirring, measure the reaction solution at this time and record it as V, then raise the temperature to 50°C and stir for 20 hours. After the reaction, remove most of the solvent by distillation , the volume is concentrated to 32% V, the insoluble matter is removed by filtration, the residual liquid is passed through ionic macroporous adsorption resin D101 to remove inorganic salt ions to obtain an aqueous solution of betaine, most of the ...

Embodiment 3

[0030] a. Add 89g, methyl glycine, 1000g acetonitrile and 277.2g sodium bicarbonate in a three-necked flask equipped with a reflux condenser, a thermometer, a constant pressure dropping funnel and a magnetic stirring device, and fully stir for use;

[0031] b. While stirring, 346.5 g of methyl methanesulfonate was added dropwise, and after the addition was completed, the temperature was gradually raised to room temperature, then heated to reflux and fully stirred and reacted for 24 hours.

[0032] c. After the reaction was over, add 890g of aqueous sodium hydroxide solution with a mass fraction of 5% under stirring, record the volume of the reaction solution as V, then raise the temperature to 50°C and stir for 20 hours. After the reaction, most of the solvent was removed by distillation, and the volume Concentrate to 30% V, filter to remove insoluble matter, the residual liquid passes through ionic macroporous adsorption resin D101 to remove inorganic salt ions to obtain be...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
pore sizeaaaaaaaaaa
melting pointaaaaaaaaaa
melting pointaaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation method of betaine. Specifically the method comprises the following steps: uniformly mixing glycine methyl ester, acetonitrile and sodium bicarbonate, dropwise adding methyl methanesulfonate, and stirring to enable the materials to react for 16 to 32h; adding a sodium hydroxide solution into reactant, rising the temperature to 50 DEG C, stirring to enable the materials to react for 20 h, then distilling to remove solvent, obtaining filtrate through filtering, removing foreign ions through adsorption, distilling the filtrate at ordinary pressure, collecting precipitated solid, performing vacuum drying, and then obtaining the betaine. All the raw materials related involved in the synthetic method adopted can be purchased in the market, and the operation of all the steps is simple, and the product cost can be effectively reduced; the condition of each step in the reaction is mild, and the safety is high; toxic and harmful substances are not produced, so the method is green and environmentally friendly; the yield of reaction products is high, and the method is easy for large-scale popularization and application.

Description

technical field [0001] The invention relates to the field of chemical industry, in particular to a preparation method of betaine. Background technique [0002] The chemical name of betaine is betaine, and its molecular formula is: C 5 h 11 NO 2 , Molecular weight: 117.15, white fluid crystal powder, melting point: 293°C (decomposition), chemical structure similar to amino acid. Betaine itself is an intermediate product of metabolism in animals. It has been proved by a large number of experiments that betaine and its salts are non-toxic, harmless and non-polluting, and are recognized as safe substances. Betaine can promote animal fat metabolism, relieve stress, regulate As a feed additive, it plays an important role in animal husbandry. It participates in the metabolism of biological organisms, forms a methyltransferase with cysteine, and provides active methyl groups. Adding it to animal feed can ensure the health of livestock and poultry. Healthy growth, increase the co...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C227/18C07C229/12
Inventor 邹益东邹苏燕朱建泉邹三元张万欢
Owner 宜兴市天石饲料有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com