Amphiphilic fluorine-containing block copolymer antibacterial material and preparation method thereof
A technology of block copolymers and antibacterial materials, which is applied in the field of amphiphilic fluorine-containing block copolymer antibacterial materials and its preparation, and can solve the problems of being unable to be directly immobilized, unable to form non-eluting antibacterial materials, and limited application range, etc. problems, to achieve the effect of sterilization and inhibition of bacterial reproduction, reproducible antibacterial properties, and excellent mechanical properties
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[0039] The preparation method of the amphiphilic fluorine-containing block copolymer antibacterial material corresponding to the above general formula includes the following steps:
[0040] 1) Add fluorine-containing acrylate monomers, catalysts, initiators and solvent I into the polymerization bottle, remove oxygen, pass in protective gas, fully react, purify and dry, to obtain product A;
[0041] 2) Add product A, acrylate monomers, catalyst and solvent I into a polymerization bottle, remove oxygen, pass in protective gas, fully react, purify and dry, to obtain product B;
[0042] 3) Add product B, glycidyl methacrylate, catalyst and solvent I to the polymerization bottle, remove oxygen, pass in protective gas, fully react, purify and dry to obtain product C;
[0043] 4) Add product C, 5,5-dimethyl hydantoin, alkaline catalyst and solvent II into the polymerization bottle, fully react, and after purification, put the product in the active halogen solution soaking, then washing and dr...
Example Embodiment
[0063] Example 1:
[0064] 1) After mixing 18.9mmol of hexafluorobutyl methacrylate and 10ml of cyclohexanone, vent oxygen with nitrogen; add 0.1mmol of cuprous chloride, 0.3mmol of bipyridine and 10ml of cyclohexanone to the polymerization bottle and seal Vacuum and fill with nitrogen three times; then use a syringe to inject the hexafluorobutyl methacrylate monomer solution, and add 0.1mmol of the initiator α-ethyl bromopropionate, liquid nitrogen freeze-thaw-vacuum three times, and finally pass Under nitrogen protection, heated to 80°C under 300 rpm magnetic stirring, reacted for 8 hours, cooled to room temperature in an ice salt bath to terminate the reaction. The product was dissolved in tetrahydrofuran, neutral alumina was passed through a column to remove impurities, and precipitated in a methanol / water (1:1, v / v) mixed solvent. The precipitate was vacuum dried at 40°C to constant weight;
[0065] 2) Add the product of step 1), 94.3mmol of butyl methacrylate, 0.78mmol of c...
Example Embodiment
[0068] Example 2:
[0069] 1) After mixing 5mmol of dodecafluoroheptyl methacrylate with 10ml of toluene, vent oxygen with nitrogen; add 0.05mmol of cuprous chloride, 0.15mmol of pentamethyldiethylenetriamine and 10ml of toluene into the polymerization bottle , Sealed and evacuated, filled with nitrogen three times; then inject the dodecafluoroheptyl methacrylate monomer solution with a syringe, and add 0.05mmol of the initiator α-ethyl bromoisobutyrate, liquid nitrogen freeze-thaw-vacuum Three times, at the end, it was protected by nitrogen, heated to 100°C under 400 rpm magnetic stirring, reacted for 8 hours, and cooled to room temperature in an ice salt bath to terminate the reaction. The product was dissolved in tetrahydrofuran, neutral alumina was passed through the column to remove impurities, and precipitated in a methanol / water (1:1, v / v) mixed solvent. The precipitate was vacuum dried at 40°C to constant weight;
[0070] 2) Add the product of step 1), 94.3mmol ethyl meth...
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