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A kind of nickel-titanium alloy drug-loaded material and preparation method thereof

A nickel-titanium alloy and drug-loading technology, which is applied in metal material coating technology, pharmaceutical formulations, drug delivery, etc., can solve the problems of low drug loading, infection, and uncontrollable drug release, so as to improve sensitivity and promote absorption , Excellent biocompatibility effect

Active Publication Date: 2018-05-08
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In order to solve the defects of the existing medical nickel-titanium alloy drug-loading method, which is easy to cause infection, low drug-loading capacity, and difficult to control drug release, the present invention provides a drug-loading material and drug-loading method to meet the clinical requirements of drug-loaded nickel-titanium alloy. performance requirements

Method used

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  • A kind of nickel-titanium alloy drug-loaded material and preparation method thereof
  • A kind of nickel-titanium alloy drug-loaded material and preparation method thereof
  • A kind of nickel-titanium alloy drug-loaded material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] A nickel-titanium disc with a diameter of 12 mm and a thickness of 1 mm was cleaned with alcohol, deionized water and ultrasonic cleaning in sequence, each time for 15 minutes. The hydrothermal treatment was carried out with 5mol / L sodium hydroxide as the medium, the hydrothermal temperature was 120°C, and the time was 8h. After hot water, rinse with a large amount of deionized water, and then carry out acid treatment and boiling water bath successively. During acid treatment, soak the sample in 0.1mol / L dilute hydrochloric acid, the amount of dilute hydrochloric acid is 5mL dilute hydrochloric acid for each sample. Soaking time is 2h. The boiling water bath time is 1h;

[0035] figure 1 (HT) is the low-power and high-power scanning electron microscope pictures of the nickel-titanium surface topography obtained through the modification of the present embodiment. As can be seen from the figure, the surface after treatment presents a sheet-like nanostructure, the lengt...

Embodiment 2

[0037] The sample treated in Example 1 was immersed in a sodium polystyrene sulfonate solution containing 6mmol / L sodium chloride, and the concentration of sodium polystyrene sulfonate was 2g / L. The reaction temperature is 60°C, and the treatment time is 48h;

[0038] figure 1 (HT / PSS) is the SEM picture of the sample after the treatment in Example 2. It can be seen from the figure that a network structure composed of polystyrene sodium sulfonate nanowires appears on the layered double hydroxide nanosheets on the surface of the material.

Embodiment 3

[0040] The sample prepared in Example 2 was placed in 1 mL with a concentration of 1×10 -4 mol / L doxorubicin hydrochloride solution, let stand at 37°C for 24h. figure 1 (LDH / PSS / Dox) is the SEM picture of the sample after the treatment in this embodiment. It can be seen from the figure that the morphology of the material does not change after loading the drug, indicating that the drug molecules are not aggregated and are evenly distributed on the surface of the material.

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Abstract

The present invention relates to a nickel-titanium alloy drug loading material and a preparation method thereof, the nickel-titanium alloy drug loading material includes a nickel-titanium alloy, a nickel-titanium layered double hydroxide layer formed by surface chemical treatment of the nickel-titanium alloy, and a network structure which is formed on the nickel-titanium layered double hydroxide layer by chemical modification and comprises sodium polystyrenesulfonate nanowires. The specific surface area of the material prepared by the method is significantly increased, and the drug loading is enlarged and can reach 80%. Drug release amount is significantly increased under acidic conditions, and selective release of drugs in different conditions can be achieved. In addition, after modification, a drug coating has good biocompatibility, and security is greatly improved. In addition, ways for the drugs to enter cells can be changed, the sensitivity of cancer cells to the drugs is improved, the drug absorption of the cancer cells can be promoted, and damage of the drugs to the cancer cells can be enhanced.

Description

technical field [0001] The invention relates to a biomedical nickel-titanium alloy drug-loading material and its preparation method and application, specifically, it relates to a method of constructing nickel-titanium layered double hydroxide on the surface of the material through alkaline hydrothermal treatment, and further utilizing polystyrene The invention relates to a drug-loading mode in which sodium sulfonate modifies the surface and carries out drug loading, and belongs to the technical field of metal material surface modification. Background technique [0002] Due to its excellent mechanical properties and better biocompatibility, biomedical nickel-titanium alloys are widely used as various scaffold materials for palliative treatment of bile duct, esophagus, trachea, and bronchial obstruction caused by malignant tumors ( Radiology 1993, 187:661-665.). However, nickel-titanium itself does not have an anti-cancer effect. After the stent is implanted, tumor cells can ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10A61L31/02A61L31/08A61L31/16C23C22/60C23C22/73
CPCA61L31/022A61L31/088A61L31/10A61L31/16A61L2300/416A61L2400/18A61L2420/08C23C22/60C23C22/73
Inventor 刘宣勇王东辉
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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