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HA (Hydroxyapatite) coating with high degree of crystallinity and nano-structure and preparation method of HA coating

A technology of hydroxyapatite and nanostructure, which is applied in coating, metal material coating technology, medical science, etc., can solve the problems of unsatisfactory osteogenesis and osseointegration performance, lack of osteogenic differentiation of induced stem cells, etc., to promote Adhesion of osteoblasts, improvement of osseointegration performance, and simple and easy process

Inactive Publication Date: 2016-06-08
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with the nanostructure of human bone, the micron grain-scale HA coating lacks the effect of inducing osteogenic differentiation and osteogenesis of stem cells, and the new bone often cannot fill the gap between the implant and the host tissue well, making early osteogenesis difficult. And osseointegration performance is not ideal (Biomaterials, 2005; 26:3631-38.)

Method used

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  • HA (Hydroxyapatite) coating with high degree of crystallinity and nano-structure and preparation method of HA coating
  • HA (Hydroxyapatite) coating with high degree of crystallinity and nano-structure and preparation method of HA coating
  • HA (Hydroxyapatite) coating with high degree of crystallinity and nano-structure and preparation method of HA coating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] A. Preparation of plasma spray particles by sintering-crushing method

[0052] Take 200g of HA powder and 16g of PVA with a concentration of 10% and mix them evenly, then use the dry pressing method, pressurize 25MPa, and make a large piece with a diameter of 40mm, and calcinate and keep it at 1050°C for 5h, and get HA ceramic pieces after cooling in the furnace . Crushing the obtained ceramic sheet in a mortar, passing through 200-mesh and 400-mesh sieves to obtain particles with a particle size of 40-80 μm as a raw material for plasma spraying;

[0053] B. Preparation of HA coating by atmospheric plasma spraying

[0054] First, after the surface of the titanium alloy sheet (10mm×10mm×2mm) is sandblasted, it is ultrasonicated in an absolute ethanol solution for 10 minutes, rinsed with deionized water for 2-3 times, dried at 100°C, and set aside; then, Using the atmospheric plasma spraying process, the HA particles with a particle size of 40-80 μm described in A are s...

Embodiment 2

[0059] The HA coating prepared by atmospheric plasma spraying in Example 1 was hydrothermally heated at 180° C. for 24 hours in a pH=9 aqueous solution, and the specific hydrothermal treatment process was the same as in Example 1. The X-ray diffraction pattern confirms that the coating is a hydroxyapatite phase after hydrothermal treatment, and the amorphous phase is reduced (such as figure 1 shown in C); the calculated crystallinity (as figure 2 Shown in C) the results show that after hydrothermal treatment, the degree of crystallinity is increased from 53% to more than 85%, which is far higher than the requirement of not less than 62% for the degree of crystallinity in the medical device industry standard; scanning electron microscopy shows the surface morphology of the coating for disordered nanostructures (such as image 3 Shown in C); the results of degradability experiments show that hydrothermal treatment can improve its chemical stability. The experimental results o...

Embodiment 3

[0061] The HA coating prepared by atmospheric plasma spraying in Example 1 was hydrothermally heated at 180° C. for 24 hours in a pH=11 aqueous solution, and the specific hydrothermal treatment process was the same as that in Example 1. The X-ray diffraction pattern confirms that the coating is a hydroxyapatite phase after hydrothermal treatment, and the amorphous phase is reduced (such as figure 1 Shown in D); the calculated crystallinity (as figure 2 Shown in D) the result shows, after hydrothermal treatment, crystallinity is improved to more than 86% by 53%, is far higher than the requirement of crystallinity not less than 62% of medical device industry standard; Scanning electron microscope shows coating surface topography for disordered nanostructures (such as image 3 Shown in D); the results of degradability experiments show that hydrothermal treatment can improve its chemical stability. The experimental results of cells also show that the highly crystalline nanostru...

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Abstract

The invention relates to an HA (Hydroxyapatite) coating with high degree of crystallinity and a nano-structure and a preparation method of the HA coating. The HA coating comprises 95% or above of hydroxyapatite, the degree of crystallinity is 85% or above, and the surface structure of the HA coating comprises the nano-structure. The HA coating has high purity and high degree of crystallinity, so that the problems that the phase decomposition and low degree of crystallinity of the traditional coating cause the coating degradation, and further, the coating falls off, an implant becomes loose, and the like, are solved; meanwhile, the coating has the nano-structure, and can promote the adhesion and proliferation of osteoblasts and the osteogenic differentiation, so that the osseointegration performance of the implant of the HA coating is improved.

Description

technical field [0001] The invention relates to the combination of atmospheric plasma spraying and low-temperature hydrothermal treatment technology to realize the preparation of high crystallinity and nanostructure HA coating, and a novel hard tissue replacement material with excellent osseointegration performance, which belongs to the field of biomedical materials. Background technique [0002] Due to diseases, car accidents, and aging, a large number of patients with hard tissue damage require surgical treatment every year. According to statistics, the annual market value of bone repair materials was as high as 20 million US dollars in 2013, and continued to increase at an annual growth rate of 20-27%. [0003] Due to its excellent mechanical properties, easy processing, and good corrosion resistance, titanium alloy has become a commonly used metal implant material in clinical practice, especially in the field of mechanical load-bearing bone / tooth restoration. However, l...

Claims

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Application Information

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IPC IPC(8): A61L27/06A61L27/32C23C4/12C23C4/04
Inventor 王秀惠林开利常江谢有桃郑学斌金晓刚
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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