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Manufacturing method and application of electrochemiluminescence nonyl phenol sensor based on titanium dioxide nanosheet composite

A titanium dioxide and electrochemistry technology, applied in the field of preparation of electrochemiluminescence nonylphenol sensor, can solve the problems of poor conductivity, unfavorable practical application, low sensitivity of electrochemiluminescence sensor, etc. The effect of improving energy transfer ability and increasing the intensity of electrochemiluminescence

Inactive Publication Date: 2016-06-22
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the poor conductivity of titanium dioxide also limits the sensitivity of electrochemiluminescence sensors constructed from a single titanium dioxide nanomaterial, which is not conducive to practical applications.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 FeCo-NTiO 2 preparation of

[0037] First, take 0.8mmol iron salt, 0.8mmol cobalt salt and 1mmol ammonium salt and add them to 5mL tetrabutyl titanate. During stirring, slowly add 0.5mL hydrofluoric acid, react in the reactor at 160°C for 24 hours, cool After reaching room temperature, centrifuge and wash with ultrapure water and absolute ethanol three times, then vacuum-dry at 50°C; then, put the ground powder into a muffle furnace with a heating rate of 1°C / min, and calcinate at 480°C for 60min ; Finally, the calcined powder is cooled to room temperature to obtain FeCo-NTiO 2 ;

[0038] Described iron salt is ferric sulfate;

[0039] Described cobalt salt is cobalt sulfate;

[0040] Described ammonium salt is ammonium sulfate.

Embodiment 2

[0041] Example 2FeCo-NTiO 2 preparation of

[0042] First, take 0.8mmol iron salt, 1.0mmol cobalt salt and 1mmol ammonium salt and add them to 5mL tetrabutyl titanate. During the stirring process, slowly add 0.65mL hydrofluoric acid, react in the reactor at 180°C for 21 hours, and cool After reaching room temperature, centrifuge and wash three times with ultrapure water and absolute ethanol, then vacuum-dry at 50°C; then, put the ground powder into a muffle furnace with a heating rate of 2°C / min, and calcinate at 520°C for 30min ; Finally, the calcined powder is cooled to room temperature to obtain FeCo-NTiO 2 ;

[0043] Described iron salt is ferric chloride;

[0044] Described cobalt salt is cobalt chloride;

[0045] Described ammonium salt is ammonium chloride.

Embodiment 3

[0046] Example 3 FeCo-NTiO 2 preparation of

[0047] First, add 0.8mmol iron salt, 1.2mmol cobalt salt and 1mmol ammonium salt to 5mL tetrabutyl titanate. During stirring, slowly add 0.8mL hydrofluoric acid, react in the reactor at 200°C for 18 hours, cool After reaching room temperature, centrifuge and wash three times with ultrapure water and absolute ethanol, and then vacuum-dry at 50°C; then, put the ground powder into a muffle furnace with a heating rate of 3°C / min, and calcinate at 560°C for 10 min ; Finally, the calcined powder is cooled to room temperature to obtain FeCo-NTiO 2 ;

[0048] Described iron salt is ferric nitrate;

[0049] Described cobalt salt is cobalt nitrate;

[0050] Described ammonium salt is ammonium nitrate.

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Abstract

The invention discloses a manufacturing method and application of an electrochemiluminescence nonyl phenol sensor based on a titanium dioxide nanosheet composite and belongs to the technical field of novel nano functional materials and bio-sensors. The manufacturing method includes: preparing a novel two-dimensional sheet magnetic nano photosensitive material FeCo-N@TiO2; utilizing good biocompatibility, large specific surface area and ferromagnetism to load an upper nonyl phenol antibody; detecting through horse radish peroxidase having cross-linking effect, wherein the horse radish peroxidase can catalyze hydrogen peroxide to generate oxygen in situ; enabling the oxygen and a base solution to be in electrochemical reaction to generate high and stable electrochemiluminescence signals, utilizing influence on electron transport capability by specific quantitative combining of the antibody and antigen to correspondingly reduce the electrochemiluminescence signals, and finally obtaining the electrochemiluminescence bio-sensor which is low in cost, high in sensitivity and specificity, quick in detection, simple to manufacture and supportive of detection on nonyl phenol.

Description

technical field [0001] The invention relates to a preparation method of an electrochemiluminescent nonylphenol sensor. It belongs to the technical field of new nanometer functional materials and biosensors. Background technique [0002] Environmental estrogen refers to a class of compounds that interfere with the synthesis, release, transport, binding, and metabolism of normal endocrine substances in the body after entering the body, activate or inhibit the function of the endocrine system, and thereby destroy the stability and regulation of the body. There are many kinds of environmental estrogens, including synthetic compounds and plant natural estrogens, which are widely distributed in nature. Nonylphenol is a bisphenol-like synthetic estrogen. At present, the methods for detecting nonylphenol mainly include chromatography and mass spectrometry. Such methods require expensive instruments and complex operations, and laboratory personnel need professional training before...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/558G01N33/532G01N27/26
CPCG01N27/26G01N33/532G01N33/558
Inventor 张勇魏琴胡丽华任祥孙旭
Owner UNIV OF JINAN
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