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Pharmaceutical composition for improving osteoarticular diseases, disintegrating tablets and preparation method of pharmaceutical composition

A technology for bone and joint diseases and compositions, which is applied in the field of pharmaceutical compositions for improving bone and joint diseases, and can solve problems such as insignificant drug effects and slow onset of bone and joint diseases

Inactive Publication Date: 2016-07-20
BEIJING KANGLIJI BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing drugs for the treatment of bone and joint diseases have slow onset of action and insignificant drug effects, and cannot meet the diversified needs of the market for related drugs or health products. Therefore, it is necessary to provide a new drug with obvious effects on bone and joint diseases Or health products, providing more choices for patients with bone and joint diseases

Method used

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  • Pharmaceutical composition for improving osteoarticular diseases, disintegrating tablets and preparation method of pharmaceutical composition
  • Pharmaceutical composition for improving osteoarticular diseases, disintegrating tablets and preparation method of pharmaceutical composition
  • Pharmaceutical composition for improving osteoarticular diseases, disintegrating tablets and preparation method of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Formula: 95 parts of glucosamine, 15 parts of taurine, 20 parts of microcrystalline cellulose, 15 parts of crospovidone, 10 parts of xylitol, 5 parts of hydroxypropyl methylcellulose, 2.8 parts of talc, micronized 2.8 parts of silica gel, 1.4 parts of magnesium stearate.

[0040] Process: Weigh each raw material according to the prescription, crush glucosamine, taurine, microcrystalline cellulose, xylitol and partially cross-linked povidone, mix them evenly, put them in a mixer, and add hydroxypropyl methylcellulose , and stir evenly to make a soft material. Extrude the soft material through the sieve to make granules, or pass the soft material through the sieve twice to make the granules more uniform and less fine powder. Place the wet granules in a desiccator to remove excess moisture from the granules. Arranging the dried granules to disperse the agglomerated and cohesive granules to obtain granules of uniform size. After the granulation is completed, add talcum p...

Embodiment 2

[0042] Formula: 95 parts of glucosamine, 25 parts of taurine, 20 parts of microcrystalline cellulose, 15 parts of crospovidone, 10 parts of xylitol, 8 parts of hydroxypropyl methylcellulose, 2.8 parts of talcum powder, micronized 2.8 parts of silica gel, 1.4 parts of magnesium stearate.

[0043] Disintegrating tablets were prepared according to the same preparation process as in Example 1.

Embodiment 3

[0045] Formula: 105 parts of glucosamine, 15 parts of taurine, 25 parts of microcrystalline cellulose, 18 parts of crospovidone, 16 parts of xylitol, 7 parts of hydroxypropyl methylcellulose, 4 parts of talc, micronized 4 parts of silica gel, 2 parts of magnesium stearate.

[0046] Disintegrating tablets were prepared according to the same preparation process as in Example 1.

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Abstract

The invention provides a pharmaceutical composition for improving osteoarticular diseases, disintegrating tablets and a preparation method of the pharmaceutical composition. The pharmaceutical composition comprises main materials and auxiliary materials. The main materials comprises, by weight, 80-120 parts of glucosamine and 10-30 parts of taurine. The pharmaceutical composition has the advantages that the glucosamine which serves as the final degradation product of chitin has activities for treating arthritis, stimulating protein polysaccharide synthesizing, and the like, can enhance the self-repairing ability of cartilage, can activate NK and LAK cells, and has an immune regulation function; the taurine which serves as the nutrient enhancer is applied to anti-fatigue nutritious food and can increase the immune function of a human body; the glucosamine and the taurine are used as the main materials, the weight of the glucosamine and the taurine are controlled in the above range, the glucosamine and the taurine are combined to achieve a synergic effect, the cartilage matrix is stabilized favorably, bone density is enhanced favorably, the symptoms of osteoarthritis is improved comprehensively, joint pain is relieved, the immunity of middle-aged and elder people is increased, and bone health problems such as bone aging are slowed.

Description

technical field [0001] The invention relates to the field of medical care, in particular to a pharmaceutical composition for improving bone and joint diseases, a disintegrating tablet and a preparation method thereof. Background technique [0002] Cartilage is composed of a small part of chondrocytes and most of the cartilage matrix, which is mainly composed of proteoglycans, collagen fibers and water. As we age, the joint cartilage in the body degenerates and wears away, leading to arthritic diseases and osteoarthritis. [0003] Osteoarthritis is the most common joint disease, which is defined by the American College of Rheumatology as a heterogeneity of joint symptoms and signs caused by damage to the integrity of articular cartilage, subchondral bone plate and joint edge bone lesions Disease, that is, a chronic joint disease of degeneration of articular cartilage and secondary bone hyperplasia. Its main symptoms are pain and loss of function caused by the degeneration o...

Claims

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Application Information

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IPC IPC(8): A61K31/7008A61K31/185A61K9/20A61P19/02A61P29/00A61P19/08A61P37/04
CPCA61K31/7008A61K9/2027A61K9/2054A61K9/2072A61K31/185
Inventor 寇爽许伯慧佘佐彦
Owner BEIJING KANGLIJI BIOLOGICAL TECH CO LTD
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