Self-catalyzed repairing hydrogel as well as preparation method and application thereof

A technology for water repair and autocatalysis, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and pharmaceutical sciences. It can solve problems such as catalyst dependence, avoid side effects, ensure biocompatibility, and get rid of dependence. Effect

Active Publication Date: 2016-09-07
HANDAN WARREN MORE TECHNICAL DEV CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to provide a self-catalyzed repairing hydr...

Method used

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  • Self-catalyzed repairing hydrogel as well as preparation method and application thereof
  • Self-catalyzed repairing hydrogel as well as preparation method and application thereof
  • Self-catalyzed repairing hydrogel as well as preparation method and application thereof

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preparation example Construction

[0043] The embodiment of the present invention also discloses a preparation method of self-catalyzed repairing hydrogel, comprising the following steps:

[0044] a, copolymerization, 100 parts by weight of isopropylacrylamide and 5 to 400 parts (preferably 5 to 100 parts) of acrylate compounds are dissolved in a solvent, and free radical copolymerization (preferably living free radical polymerization) ), the reaction temperature is 30-120°C (preferably 60-100°C), the reaction time is 2-24h, preferably (12-24h), after the polymerization is completed, a precipitant is added to the reaction solution, and the residual monomer is removed by precipitation. (N-isopropylacrylamide)-acrylate copolymer was obtained. Among them, the acrylate compound is methyl acrylate, methyl methacrylate, ethyl acrylate, ethyl methacrylate, butyl acrylate, butyl methacrylate, hydroxyethyl acrylate or hydroxyethyl methacrylate One or more, preferably acrylate; the solvent used is N,N-dimethylformamide,...

Embodiment 1

[0048] Copolymerization: Dissolve 10gNIPAM, 1g methyl acrylate, 5mg azobisisobutyronitrile (AIBN) and 50mgDDMAT chain transfer agent (DDMAT is dodecyl trithiocarbonate) in 15mL dioxane, and Add it into a 50mL reaction bottle, remove the oxygen in the system, and raise the temperature to 60°C under magnetic stirring to perform reversible addition-fragmentation chain transfer radical polymerization. The reaction time is 24h. After the reaction is completed, cool the reaction system and precipitate it with petroleum ether. Twice, remove the unreacted monomer, vacuum dry to get white powder, that is (N-isopropylacrylamide)-methyl acrylate copolymer, weigh and calculate monomer conversion rate and average molecular weight, and repeat in the copolymer The mass ratio of the unit NIPAM to the repeating unit methyl acrylate is about 10:1.

[0049] Hydrazinolysis: Dissolve 5g of the above copolymer in 10mL of methanol, then add 3.6mL of hydrazine hydrate, heat up to 70°C, hydrazinolysis...

Embodiment 2

[0056] Copolymerization: Dissolve 10g of NIPAM, 10g of butyl acrylate and 0.2g of azobisisobutyronitrile in 20mL of dioxane, and add it into a 100mL reaction bottle, and raise the temperature to 60°C under magnetic stirring and nitrogen protection for ordinary free reaction. base polymerization, the reaction time is 8h, after the reaction is over, the reaction system is cooled, precipitated twice with petroleum ether, the unreacted monomer is removed, and the white powder is obtained by vacuum drying, namely (N-isopropylacrylamide)-butyl acrylate For ester copolymers, the mass ratio of the two repeating units in the copolymer is about 1:1.

[0057] Hydrazinolysis: Dissolve 5g of the above copolymer in a mixed solvent of 5mL ethanol and 10mL hydrazine hydrate, raise the temperature to 80°C, and perform hydrazinolysis for 48 hours, then put the reaction mixture into a dialysis bag and dialyze with deionized water for 48 hours to remove excess hydration Hydrazine and ethanol, fre...

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Abstract

The invention provides a self-catalyzed repairing hydrogel as well as a preparation method and an application thereof. The self-catalyzed repairing hydrogel is generated by reacting (N-isopropylacrylamide)-acrylhydrazine copolymer with a multicarbonyl compound in an aqueous solution, wherein a molar ratio of hydrazine groups to carbonyl groups is 1.2-2: 1; the (N-isopropylacrylamide)-acrylhydrazine copolymer comprises a repeating unit A and a repeating unit B. The self-catalyzed repairing hydrogel of the present invention is capable of realizing a self-catalyzed self-repairing process with a biocompatible polymer PN/PAM as a main body and a biocompatible multicarbonyl compound as a cross-linking agent. In such a way, side effects caused by added catalysts are avoided, and dependence on catalysts is decoupled; the biocompatibility of the self-repairing hydrogel and the applicability thereof in the field of biomedicine are guaranteed. As a result, the defect that existing self-repairing hydrogels cannot be actually applied to the relevant art of biomedicine is overcome.

Description

technical field [0001] The invention relates to a hydrogel and its preparation method and application, in particular to a self-catalyzed repair hydrogel and its preparation method and application. Background technique [0002] Hydrogel is a gel with water as the dispersion medium. It is a polymer network system with soft properties, can maintain a certain shape, and can absorb a large amount of water. Hydrogel is to introduce some hydrophobic groups and hydrophilic residues into the water-soluble polymer with network cross-linked structure. The hydrophilic residues combine with water molecules to connect the water molecules inside the network, while the hydrophobic residues Cross-linked polymer that swells with water. [0003] Self-healing hydrogel is a hydrogel with self-healing ability after being damaged by the outside world. Self-healing is one of the biggest differences between living and non-living bodies. When the body is injured by the outside world, the wounds of l...

Claims

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Application Information

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IPC IPC(8): C08G81/02C08F220/54C08F220/14C08F220/28C08F8/32A61L27/16A61L27/52A61K47/32
CPCA61K47/32A61L27/16A61L27/52C08F8/32C08F220/14C08F220/54C08G81/025C08L87/005C08F220/281
Inventor 秦江雷常瑞雪李旭安恒
Owner HANDAN WARREN MORE TECHNICAL DEV CO LTD
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