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Low-precipitation medical plastic catheter material and preparation method thereof

A plastic and catheter technology, applied in the field of medical materials, can solve the problems of PVC plastic catheters such as high hardness, poor light resistance and thermal stability, organ toxicity and side effects, and achieve excellent aging performance, good stability, and no cytotoxicity.

Inactive Publication Date: 2016-09-21
林春梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Among many medical plastic catheters, PVC plastic catheters are the most widely used due to their good chemical resistance, mechanical properties, electrical properties, high transparency and high cost performance. However, PVC plastic catheters have high hardness, light resistance and thermal stability. Poor, usually some additives are added during the preparation process, such as plasticizers, antioxidants, heat stabilizers, etc.
However, during use, these additives will be precipitated and flow into the human body with the liquid medicine or blood, causing toxic and side effects to various organs of the human body, and what is even more carcinogenic, endangering human health

Method used

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  • Low-precipitation medical plastic catheter material and preparation method thereof

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Comparison scheme
Effect test

Embodiment 1

[0022] A low-leaching medical plastic catheter material, comprising the following components in parts by weight: 35 parts of polyvinyl chloride resin, 20 parts of polyether ether ketone resin, 15 parts of polycarbonate, 4 parts of succinic anhydride, glyceryl methacrylate 3 parts, 2 parts of hydroxypropyl methylcellulose, 0.02 parts of heparin, 6 parts of sodium bisulfite, 3 parts of cyclodextrin, 5 parts of epoxy soybean oil, 4 parts of carbon black, 4 parts of calcium stearate, wood 6 parts of sugar alcohol, 1 part of cysteine, 3 parts of polyvinyl alcohol.

[0023] Wherein, the average degree of polymerization of the polyvinyl chloride resin is 750-1200. The molecular weight of the heparin is 12kD-20kD.

[0024] The preparation method of the above-mentioned low-leaching medical plastic catheter material comprises the following preparation steps:

[0025] 1) Add polyvinyl chloride resin, polyetheretherketone resin, polycarbonate, and glycerol methacrylate into the mixer, a...

Embodiment 2

[0030] A low-leaching medical plastic catheter material, comprising the following components in parts by weight: 47 parts of polyvinyl chloride resin, 28 parts of polyether ether ketone resin, 18 parts of polycarbonate, 6 parts of succinic anhydride, glyceryl methacrylate 5 parts, 4 parts of hydroxypropyl methylcellulose, 0.03 parts of heparin, 8 parts of sodium bisulfite, 6 parts of cyclodextrin, 7 parts of epoxy soybean oil, 7 parts of carbon black, 8 parts of calcium stearate, wood 8 parts of sugar alcohol, 3 parts of cysteine, 5 parts of polyvinyl alcohol.

[0031] Wherein, the average degree of polymerization of the polyvinyl chloride resin is 750-1200. The molecular weight of the heparin is 12kD-20kD.

[0032] The preparation method of the above-mentioned low-leaching medical plastic catheter material comprises the following preparation steps:

[0033] 1) Add polyvinyl chloride resin, polyetheretherketone resin, polycarbonate, and glycerol methacrylate into the mixer, ...

Embodiment 3

[0038] A low-leaching medical plastic catheter material, comprising the following components in parts by weight: 60 parts of polyvinyl chloride resin, 36 parts of polyether ether ketone resin, 22 parts of polycarbonate, 9 parts of succinic anhydride, glyceryl methacrylate 8 parts, 6 parts of hydroxypropyl methylcellulose, 0.04 parts of heparin, 11 parts of sodium bisulfite, 10 parts of cyclodextrin, 9 parts of epoxy soybean oil, 10 parts of carbon black, 12 parts of calcium stearate, wood 11 parts of sugar alcohol, 6 parts of cysteine, 7 parts of polyvinyl alcohol.

[0039] Wherein, the average degree of polymerization of the polyvinyl chloride resin is 750-1200. The molecular weight of the heparin is 12kD-20kD.

[0040] The preparation method of the above-mentioned low-leaching medical plastic catheter material comprises the following preparation steps:

[0041] 1) Add polyvinyl chloride resin, polyetheretherketone resin, polycarbonate, and glycerol methacrylate into the mi...

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Abstract

The invention provides a low-precipitation medical plastic catheter material and a preparation method thereof. The medical plastic catheter material comprises vinyl chloride resin, polyetheretherketone resin, makrolon, succinic anhydride, methylacrylic acid glyceride, hydroxypropyl methyl cellulose, heparin, sodium hydrogen sulfite, cyclodextrin, epoxidized soybean oil, carbon black, calcium stearate, xylitol, aminothiopropionic acid and polyving akohol. The prepared medical plastic catheter material is high in hardness, high in tensile strength, excellent in aging resistance, good in stability, meanwhile free of cell toxicity, good in biocompatibility and applicable to medial and clinical fields, and less precipitate is produced.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a low-leaching medical plastic catheter material and a preparation method thereof. Background technique [0002] There are various materials for medical plastic catheters. It is a tubular elastic product used for medical treatment. It is mainly used for liquid or gas transportation. Common ones include infusion hoses, blood catheters, blood pumping hoses, and stethoscope hoses. Medical catheters are mainly made of medical polymer materials with good biocompatibility, such as silicone rubber, polyurethane, polyethylene, polypropylene, polyvinyl chloride, polymethyl methacrylate, polyethylene terephthalate Ester, nylon, ABS, polycarbonate, etc. The prepared medical plastic catheter should have the characteristics of not easy to deform, corrosion resistance, high temperature resistance or ultraviolet disinfection, and smooth inner surface. [0003] Among many medical pl...

Claims

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Application Information

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IPC IPC(8): C08L27/06C08L61/16C08L69/00C08L5/16C08K13/02C08K5/1515C08K3/04C08K5/098B29C47/92B29C48/92
CPCC08L27/06B29C48/92B29C2948/92704C08L2205/02C08L2205/035C08L61/16C08L69/00C08L5/16C08K13/02C08K5/1515C08K3/04C08K5/098
Inventor 林春梅
Owner 林春梅