Magnetic nanometer diagnosis and treatment agent and preparation method and application thereof

A magnetic nanometer and nanoparticle technology, which is applied in general/multifunctional contrast agents, pharmaceutical formulations, echo/ultrasonic imaging agents, etc., can solve problems such as high cost and complicated preparation methods, and achieve stable properties

Inactive Publication Date: 2016-12-07
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the preparation method of this invention is complicated, and multi-step surface modi...

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  • Magnetic nanometer diagnosis and treatment agent and preparation method and application thereof
  • Magnetic nanometer diagnosis and treatment agent and preparation method and application thereof
  • Magnetic nanometer diagnosis and treatment agent and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0088] In this embodiment, the magnetic nano-medicine is prepared by the following method, which specifically includes the following steps:

[0089] (1) 1. the chitosan quaternary ammonium salt shown in the formula (I) that the molecular weight of 2g is 100,000Da is dissolved in 50mL deionized water, is placed in the there-necked flask, reaction system is logical nitrogen 30min, and oil bath is heated up to 102 ℃, Get the reaction system a;

[0090] ②Take 0.1459g of FeCl 3 ·6H 2 O with 0.071g FeCl 2 4H 2 O was dissolved in 2 mL of hydrochloric acid solution with a concentration of 1 mol / L to obtain solution B;

[0091] ③ Inject solution b into reaction system a in step (1), slowly add 15 mL of concentrated ammonia water dropwise to pH = 10; reflux at 80-120°C for 40 minutes to obtain reaction system c;

[0092] ④ After cooling the reaction system c in step (3) to room temperature, move all the reaction solution to a dialysis bag, and dialyze with deionized water at 20°C t...

Embodiment 2

[0107] In this embodiment, the magnetic nano-medicine is prepared by the following method, which specifically includes the following steps:

[0108] (1) 1. the chitosan quaternary ammonium salt shown in the formula (I) that the molecular weight of 2g is 100,000Da is dissolved in 50mL deionized water, is placed in the there-necked flask, reaction system is logical nitrogen 30min, and oil bath is heated up to 102 ℃, Get the reaction system a;

[0109] ②Take 0.1459g of FeCl 3 ·6H 2 O with 0.071g FeCl 2 4H 2 O was dissolved in 2 mL of hydrochloric acid solution with a concentration of 1 mol / L to obtain solution b;

[0110] ③ Inject solution b into reaction system a in step (1), slowly add 15 mL of concentrated ammonia water dropwise to pH = 10; reflux at 80-120°C for 40 minutes to obtain reaction system c;

[0111] ④ After cooling the reaction system c in step (3) to room temperature, move all the reaction solution to a dialysis bag, and dialyze with deionized water at 20°C t...

Embodiment 3

[0118] In this embodiment, the magnetic nano-medicine is prepared by the following method, which specifically includes the following steps:

[0119] (1) ① Dissolve 1.5 g of chitosan quaternary ammonium salt represented by formula (I) with a molecular weight of 100,000 Da in 50 mL of deionized water, place it in a three-necked flask, pass nitrogen to the reaction system for 20 minutes, and heat up the oil bath to 110 ° C , get the reaction system a;

[0120] ②Take 0.1459g of FeCl 3 ·6H 2 O with 0.1075g of FeCl 2 4H 2 O was dissolved in 4 mL of hydrochloric acid solution with a concentration of 1 mol / L to obtain solution b;

[0121] ③ Inject solution b into reaction system a in step (1), slowly add 15 mL of concentrated ammonia water dropwise to pH = 10; reflux at 80-120°C for 30 minutes to obtain reaction system c;

[0122] ④ After cooling the reaction system c in step (3) to room temperature, move all the reaction solution to a dialysis bag, and dialyze with deionized wat...

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Abstract

The invention provides a magnetic nanometer diagnosis and treatment agent and a preparation method and application thereof. The magnetic nanometer diagnosis and treatment agent comprises polypyrrole nanoparticles doped with ferroferric oxide nanoparticles and hyaluronic acid adsorbed to the surfaces of the polypyrrole nanoparticles. The nanometer diagnosis and treatment agent is small in grain size, good in penetrability, uniform in grain size, easy to purify, free of obvious cytotoxicity, good in biocompatibility, good in long circulating effect and low in long-term toxicity, and negative charges exist on the surfaces of the particles; an outstanding T2 relaxation enhancement effect is achieved, the linear relation of the T2 relaxation time reciprocal and the iron concentration change within the low concentration range is good, and the nanometer diagnosis and treatment agent has photo-acoustic imaging capability, is an ideal nanometer diagnosis and treatment agent for preparing multi-mode images and is remarkable in photo-thermal and magnetic-thermal treatment effect. The preparation method is simple, conditions are mild, cost is low, and application and popularization are easy.

Description

technical field [0001] The invention belongs to the technical field of nanometer diagnosis and treatment agent, and relates to a magnetic nanometer diagnosis and treatment agent and its preparation method and application. Background technique [0002] At present, for major diseases, it is very limited to use only one imaging method to determine the location and extent of the lesion, or to use only one method for treatment, but it has become a development trend to be able to use multiple methods for common imaging and multiple modes of treatment. trend. [0003] Photoacoustic imaging has high sensitivity and strong penetrating power, but due to the limited penetrating power of laser light, it still has certain limitations for deep tissues; nuclear magnetic imaging has strong penetrating power and high spatial resolution, and can image The quality of the test object has a great relationship with the state of the measured object. A slight movement will cause motion artifacts, ...

Claims

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Application Information

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IPC IPC(8): A61K49/22A61K49/18A61K49/12A61K41/00A61P35/00
CPCA61K49/225A61K41/0052A61K49/0002A61K49/12A61K49/1863
Inventor 陈春英周会鸽唐敬龙赵天鸣
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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