H7N9 subtype avian influenza genetic engineering vaccine taking baculovirus as carrier as well as preparation method and application of vaccine

A genetically engineered vaccine and baculovirus technology, applied in the field of H7N9 subtype avian influenza genetically engineered vaccine and its preparation, can solve the problems of chicken embryo production limitation, hidden biological safety hazards, antigen pollution, etc., and achieve the convenience of large-scale production, Facilitate mass production and improve the expression level effect
CN106421771AInactive Publication Date: 2017-02-22SOUTH CHINA AGRI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SOUTH CHINA AGRI UNIV
Publication Date
2017-02-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an H7N9 subtype avian influenza genetic engineering vaccine taking baculovirus as a carrier as well as a preparation method and an application of the vaccine and belongs to the technical field of genetic engineering. The H7N9 subtype avian influenza genetic engineering vaccine takes the baculovirus as the carrier and is a recombinant baculovirus capable of expressing main protective antigens of the avian influenza virus in vertebrate. The avian influenza genetic engineering vaccine realizing immunity through intramuscular injection is prepared. The vaccine overcomes defects that inactivated vaccines depend on chicken embryo production, the production period is long, other antigen mixed infection exists and the like, and technical reserve is provided for screening the H7N9 subtype avian influenza genetic engineering vaccine.
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Description

technical field

[0001] The invention belongs to the technical field of genetic engineering, and in particular relates to a H7N9 subtype avian influenza genetic engineering vaccine with a baculovirus as a carrier, a preparation method and application thereof. Background technique

[0002] Avian influenza virus (AIV) belongs to the Orthomyxoviridae Influenza virus genus, which has always caused serious harm to the breeding industry and human public safety. The outbreak of H7N9 subtype AIV in 2013 has aroused global attention to AIV. Although H7N9AIV has low pathogenicity to poultry and generally does not show clinical symptoms after infection, it is in a virus-carrying state, but it has strong pathogenicity to humans. In order to effectively control poultry infection of this subtype of AIV, it is urgent to develop a vaccine that can effectively prevent avian H7N9 influenza virus.

[0003] Immunization of susceptible animals with appropriate vaccines can protect susceptible b...

Claims

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